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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | Inhabition of testicular growth in rainbow trout exposed to estrogenic alkylphenolic chemicals显示文摘 | Jobling S Sheahan D Osbom JA | 1996 | Environ Toxicol Chem1996，15，： | 2 |
| 3 | A survey of estrogenic activity in United Kingdom inland waters 显示文摘 | Harries JE Sheahan DA Jobling S | 1996 | Environmental Toxicology and Chemistry1996，15，： | 1 |
| 4 | New uses for new haplotypes the human Y-chromosome,disease and selection显示文摘 | Jobling M A Tyler S C | 2000 | Trends Genet2000，16，： | 1 |
| 5 | Detergent components in sewage effluents are weakly estrogenic to fish:an in vitro study using rainbow trout hepatocytes 显示文摘 | JOBLING S SUMPTER J P | 1993 | Aqu Toxicol1993，27，： | 1 |
| 6 | Effects of stocking density on foodintake, growth performance andoxygen consumption in Artic charr (Salvelinus alpinus)显示文摘 | Jorgensen E H Christiansen J S Jobling M | 1993 | Aquaculture1993，110，： | 1 |
| 7 | Survey of estrogenic activity in United Kingdom inland waters 显示文摘 | HARRIES J E SHEAHAN D JOBLING S | 1996 | Environmental Toxicology and Chemistry1996，15，11： | 1 |
| 8 | Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals显示文摘 | Jobling S Sheahan D Osborne JA | 1996 | Environmental Toxicology and Chemistry1996，15，： | 1 |
| 9 | Detergent components in sewage effluent are weakly oestrogenic to fish : an in vitro study using rainbow trout hepatocytes 显示文摘 | Jobling S J Sumpter J P | 1993 | Aquat Toxicol1993，27，： | 1 |
| 10 | Endocrine disruption in wildlife:a critical review of the evidence显示文摘 | Tyler C R Jobling S Sumpter JP | 1998 | Critical Reviewsin Toxicology1998，28，： | 1 |
| 11 | Widespread sexual disruption in wild fish 显示文摘 | Jobling S Nolan M Tyler C R | 1998 | Environmental Science and Technology1998，32，17： | 1 |
| 12 | Production of a freeze-thaw-stable potato starch by antisense inhibition of three starchsynthase genes显示文摘 | Jobling S A Westcott R J Tayal A | 2002 | Nat Biotechnol2002，20，3： | 1 |
| 13 | Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment显示文摘 | Jobling S | 1995 | Environ Health Perspect1995，103，： | 1 |
| 14 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C R | 1998 | Environmental Science & Technology1998，32，17： | 1 |
| 15 | Estrogenic potency of effluent from two sewage treatment works in the United Kingdom显示文摘 | HARRIES J E JANBAKHSH A JOBLING S | 1999 | Environmental toxicology and chemistry1999，18，5： | 1 |
| 16 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C | 1998 | Environmental Science and Technology1998，32，17： | 1 |
| 17 | Endocrine disruption in wildlife: a critical review of the evidence 显示文摘 | Tyler C R Jobling S Sumpter J P | 1998 | Critical Reviews in Toxicology1998，28，4： | 1 |
| 18 | Environmentally persistent alkylphenolic compounds are estrogenic 显示文摘 | White R Jobling S Hoare S A | 1994 | Endocrinology1994，135，： | 1 |
| 19 | Effects of stocking density on food intake, growth performance and oxygen consumption in Arctic charr (Salvelinus alpinus) 显示文摘 | JORGENSEN E H CHRISTIANSSEN J S JOBLING M | 1993 | Aquaculture1993，110，： | 1 |
| 20 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C R Bfighty G | 1998 | Environ Sci Technol1998，32，17： | 1 |
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