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| 1 | Necroptosis in inflammatory bowel disease and other intestinal diseases显示文摘For a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, inducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis of inflammatory bowel disease(IBD) and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD. | Sha Li Long-Gui Ning Xin-He Lou Guo-Qiang Xu | 2018 | World Journal of Clinical Cases2018，6，14： | 7 |
| 2 | Genome sequences of five Sitopsis species of Aegilops and the origin of polyploid wheat B subgenome显示文摘Common wheat(Triticum aestivum,BBAADD)is a major staple food crop worldwide.The diploid progenitors of the A and D subgenomes have been unequivocally identified;that of B,however,remains ambiguous and controversial but is suspected to be related to species of Aegilops,section Sitopsis.Here,we report the assembly of chromosome-level genome sequences of all five Sitopsis species,namely Aegilops bicornis,Ae.longissima,Ae.searsii,Ae.sharonensis,and Ae.speltoides,as well as the partial assembly of the Amblyopyrum muticum(synonym Aegilops mutica)genome for phylogenetic analysis.Our results reveal that the donor of the common wheat B subgenome is a distinct,and most probably extinct,diploid species that diverged from an ancestral progenitor of the B lineage to which the still extant Ae.speltoides and Am.muticum belong.In addition,we identified interspecific genetic introgressions throughout the evolution of the Triticum/Aegilops species complex.The five Sitopsis species have various assembled genome sizes(4.11-5.89 Gb)with high proportions of repetitive sequences(85.99%-89.81%);nonetheless,they retain high collinearity with other genomes or subgenomes of species in the Triticum/Aegilops complex.Differences in genome size were primarily due to independent post-speciation amplification of transposons.We also identified a set of Sitopsis genes pertinent to important agronomic traits that can be harnessed for wheat breeding.These newly assembled genome resources provide a new roadmap for evolutionary and genetic studies of the Triticum/Aegilops complex,as well as for wheat improvement. | Lin-Feng Li Zhi-Bin Zhang Zhen-Hui Wang Ning Li Yan Sha Xin-Feng Wang Ning Ding Yang Li Jing Zhao Ying Wu Lei Gong Fabrizio Mafessoni Avraham A.Levy Bao Liu | 2022 | Molecular Plant2022，15，3： | 5 |
| 3 | Systematic analyses of glutamine and glutamate metabolisms across different cancer types显示文摘Background: Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across different cancer types, whereas such knowledge could be critical for understanding the distinct characteristics of different cancer types. Our computational study aimed to examine the functional roles of glutamine and glutamate across different cancer types.Methods: We conducted a comparative analysis of gene expression data of cancer tissues versus normal control tissues of 11 cancer types to understand glutamine and glutamate metabolisms in cancer. Specifically, we developed a linear regression model to assess differential contributions by glutamine and/or glutamate to each of seven biological processes in cancer versus control tissues.Results: While our computational predictions were consistent with some of the previous observations, multiple novel predictions were made:(1) glutamine is generally not involved in purine synthesis in cancer except for breast cancer, and is similarly not involved in pyridine synthesis except for kidney cancer;(2) glutamine is generally not involved in ATP production in cancer;(3) glutamine's contribution to nucleotide synthesis is minimal if any in cancer;(4) glutamine is not involved in asparagine synthesis in cancer except for bladder and lung cancers; and(5) glutamate does not contribute to serine synthesis except for bladder cancer.Conclusions: We comprehensively predicted the roles of glutamine and glutamate metabolisms in selected metabolic pathways in cancer tissues versus control tissues, which may lead to novel approaches to therapeutic development targeted at glutamine and/or glutamate metabolism. However, our predictions need further functional validation. | Yuan Tian Wei Du Sha Cao Yue Wu Ning Dong Yan Wang Ying Xu | 2017 | Chinese Journal of Cancer2017，36，12： | 5 |
| 4 | nID-based Internet of Things and .Its Application in Airport Aviation Risk Management显示文摘 | NING Huansheng HU Sha HE Wei XU Qunyu LIU Hong CHEN Weishi | 2012 | Chinese Journal of Electronics2012，21，2： | 5 |
| 5 | The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage显示文摘Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine,Soochow University,China(approval No.XD-2016-1)on January 15,2016. | Ning Sha Hua-Wei Wang Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang Wen-Jing Zhu Yuan-Yuan Gao Xing Feng Xin Ding | 2021 | Neural Regeneration Research2021，16，10： | 4 |
| 6 | A Platform to Improve Echinococcosis Control in Tibetan Populations-Sichuan Province,China,2015‒2020显示文摘Echinococcosis is a neglected parasitic zoonotic disease that is distributed worldwide.Previous data has shown that China holds the highest disease burden of echinococcosis in the world,resulting in 22.97×10^(5) disability adjusted life year(DALYs)lost annually(1).Echinococcosis is one of the epidemiological factors responsible for poverty in China.Since 2000,China’s central government(CG)has taken several actions to control echinococcosis in Western China.Since 2005. | Tian Tian Shuai Han Chuizhao Xue Xu Wang Shijie Yang Bo Zhong Qian Wang Wenjie Yu Sha Liao Dan Ba Ze Li Wei Li Fei Xie Qiang Wang Zelin Zhu Yuwan Hao Weiping Wu Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，5： | 2 |
| 7 | The ChinaMAP reference panel for the accurate genotypeimputation in Chinese populations显示文摘Dear Editor,The genotype imputation is an efficient and pivotal approach to estimate the unobserved genotypes in the genomic data from the single nucleotide polymorphism(SNP)genotyping arrays or whole-genome sequencing(WGS).The fine mapping of variants in the genome-wide association study(GWAS)could be critically improved by the imputation with an optimal reference panel based on the population-specific haplotypes. | Lin Li Peide Huang Xiaohui Sun Siyu Wang Min Xu Sha Liu Zhimin Feng Qing Zhang Xiaoji Wang Xiaole Zheng Mengyao Dai Yufang Bi Guang Ning Yanan Cao Weiqing Wang | 2021 | Cell Research2021，31，12： | 2 |
| 8 | Fenton reactions drive nucleotide and ATP syntheses in cancer显示文摘我们在场 14 癌症的织物 transcriptomic 数据的计算研究打字到地址:什么可以驾驶癌症房间分割?我们到由 Fenton 反应的细胞内部的 pH 的那坚持的混乱的分析点可能在癌症开发的根。明确地,我们统计上证明了 Fenton 反应发生在癌症 cytosol,越过所有 14 癌症的线粒体打字,基于经由 Michaelis-Menten 方程综合的癌症组织基因表示数据。另外,我们证明了在疾病房间的 cytosol 的(i) Fenton 反应将连续地房间由产生网质子通过综合的联合使 pH 稳定,对哪个作出回应增加他们的 pH 对哪个 glycolytic ATP 并且由核苷酸综合体消费他们,它可以驱使房间分割连续地综合的核苷酸根除;并且(ii ) 在线粒体的 Fenton 反应与最终来自 H 2 O 2, 大部分从有免疫力的房间发源。一个模型被开发连接这些到癌症开发,在一些变化可以被选择以 Fenton 反应支配的率便于房间分割的地方。 | Huiyan Sun Chi Zhang Sha Cao Tao Sheng Ning Dong Ying Xu | 2018 | Journal of Molecular Cell Biology2018，10，5： | 2 |
| 9 | A monolithically sculpted van der Waals nano-opto-electro-mechanical coupler显示文摘The nano-opto-electro-mechanical systems(NOEMS)are a class of hybrid solid devices that hold promises in both classical and quantum manipulations of the interplay between one or more degrees of freedom in optical,electrical and mechanical modes.To date,studies of NOEMS using van der Waals(vdW)heterostructures are very limited,although vdW materials are known for emerging phenomena such as spin,valley,and topological physics.Here,we devise a universal method to easily and robustly fabricate vdW heterostructures into an architecture that hosts opto-electro-mechanical couplings in one single device.We demonstrated several functionalities,including nano-mechanical resonator,vacuum channel diodes,and ultrafast thermo-radiator,using monolithically sculpted graphene NOEMS as a platform.Optical readout of electric and magnetic field tuning of mechanical resonance in a CrOCl/graphene vdW NOEMS is further demonstrated.Our results suggest that the introduction of the vdW heterostructure into the NOEMS family will be of particular potential for the development of novel lab-on-a-chip systems. | Tongyao Zhang Hanwen Wang Xiuxin Xia Ning Yan Xuanzhe Sha Jinqiang Huang Kenji Watanabe Takashi Taniguchi Mengjian Zhu Lei Wang Jiantou Gao Xilong Liang Chengbing Qin Liantuan Xiao Dongming Sun Jing Zhang Zheng Han Xiaoxi Li | 2022 | Light(Science & Applications)2022，11，3： | 1 |
| 10 | Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder显示文摘Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD. | Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang | 2023 | National Science Review2023，10，11： | 1 |
| 11 | An adaptive frame resource allocation strategy for TDMA-based cooperative transmission显示文摘 | Yang Ning Tian Hui Chen Sha sha | 2007 | IEEE Communications Letters2007，11，5： | 1 |
| 12 | Toward fine-tuned metabolic networks in industrial microorganisms显示文摘There are numerous microorganisms in nature capable of synthesizing diverse useful compounds;however,these natural microorganisms are generally inefficient in the production of target products on an industrial scale,relative to either chemical synthesis or extraction methods.To achieve industrial production of useful compounds,these natural microorganisms must undergo a certain degree of mutation or effective fine-tuning strategies.This review describes how to achieve an ideal metabolic fine-tuned process,including static control strategies and dynamic control strategies.The static control strategies mainly focus on various matabolic engineering strategies,including protein engineering,upregulation/downregulation,and combinatrorial control of these metabolic engineering strategies,to enhance the flexibility of their application in fine-tuned metabolic metworks.Then,we focus on the dynamic control strategies for fine-tuned metabolic metworks.The design principles derived would guide us to construct microbial cell factories for various useful compounds. | Ning Li Weizhu Zeng Sha Xu Jingwen Zhou | 2020 | Synthetic and Systems Biotechnology2020，5，2： | 1 |
| 13 | Design and Analysis of an MST-basedTopology Control Algorithm显示文摘 | Li Ning Hou J C Sha Lui | 2005 | IEEE Transactions on WirelessCommunications2005，4，3： | 1 |
| 14 | Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways显示文摘BACKGROUND In traditional Chinese medicine(TCM),frankincense and myrrh are the main components of the antitumor drug Xihuang Pill.These compounds show anticancer activity in other biological systems.However,whether frankincense and/or myrrh can inhibit the occurrence of hepatocellular carcinoma(HCC)is unknown,and the potential molecular mechanism(s)has not yet been determined.AIM To predict and determine latent anti-HCC therapeutic targets and molecular mechanisms of frankincense and myrrh in vivo.METHODS In the present study,which was based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(http://gffzz390fd749913b458bhnvc6qcq9nupu60ob.ffgz.tsg.suse.edu.cn/tcmsp.php),Universal Protein database(http://gffzzc0d2db89b939488bhnvc6qcq9nupu60ob.ffgz.tsg.suse.edu.cn),GeneCards:The Human Gene Database(http://gffzza6b9c6ac78e94ba9hnvc6qcq9nupu60ob.ffgz.tsg.suse.edu.cn/)and Comparative Toxicogenomics Database(http://gffzz2b6478e0a40e4229hnvc6qcq9nupu60ob.ffgz.tsg.suse.edu.cn/),the efficacy of and mechanism by which frankincense and myrrh act as anti-HCC compounds were predicted.The core prediction targets were screened by molecular docking.In vivo,SMMC-7721 human liver cancer cells were transplanted as xenografts into nude mice to establish a subcutaneous tumor model,and two doses of frankincense plus myrrh or one dose of an EGFR inhibitor was administered to these mice continuously for 14 d.The tumors were collected and evaluated:the tumor volume and growth rate were gauged to evaluate tumor growth;hematoxylineosin staining was performed to estimate histopathological changes;immunofluorescence(IF)was performed to detect the expression of CD31,α-SMA and collagen IV;transmission electron microscopy(TEM)was conducted to observe the morphological structure of vascular cells;enzyme-linked immunosorbent assay(ELISA)was performed to measure the levels of secreted HIF-1αand TNF-α;reverse transcription-polymerase chain reaction(RT-qPCR)was performed to measure the mRNA expression of HIF-1α,TNF-α,VEGF and MMP-9;and Western blot(WB)was performed to determine the levels of proteins expressed in the EGFR-mediated PI3K/Akt and MAPK signaling pathways.RESULTS The results of the network pharmacology analysis showed that there were 35 active components in the frankincense and myrrh extracts targeting 151 key targets.The molecular docking analysis showed that both boswellic acid and stigmasterol showed strong affinity for the targets,with the greatest affinity for EGFR.Frankincense and myrrh treatment may play a role in the treatment of HCC by regulating hypoxia responses and vascular system-related pathological processes,such as cytokine-receptor binding,and pathways,such as those involving serine/threonine protein kinase complexes and MAPK,HIF-1 and ErbB signaling cascades.The animal experiment results were verified.First,we found that,through frankincense and/or myrrh treatment,the volume of subcutaneously transplanted HCC tumors was significantly reduced,and the pathological morphology was attenuated.Then,IF and TEM showed that frankincense and/or myrrh treatment reduced CD31 and collagen IV expression,increased the coverage of perivascular cells,tightened the connection between cells,and improved the shape of blood vessels.In addition,ELISA,RT-qPCR and WB analyses showed that frankincense and/or myrrh treatment inhibited the levels of hypoxia-inducible factors,inflammatory factors and angiogenesis-related factors,namely,HIF-1α,TNF-α,VEGF and MMP-9.Furthermore,mechanistic experiments illustrated that the effect of frankincense plus myrrh treatment was similar to that of an EGFR inhibitor with regard to controlling EGFR activation,thereby inhibiting the phosphorylation activity of its downstream targets:the PI3K/Akt and MAPK(ERK,p38 and JNK)pathways.CONCLUSION In summary,frankincense and myrrh treatment targets tumor blood vessels to exert anti-HCC effects via EGFR-activated PI3K/Akt and MAPK signaling pathways,highlighting the potential of this dual TCM compound as an anti-HCC candidate. | Piao Zheng Zhen Huang Dong-Chang Tong Qing Zhou Sha Tian Bo-Wei Chen Di-Min Ning Yin-Mei Guo Wen-Hao Zhu Yan Long Wei Xiao Zhe Deng Yi-Chen Lei Xue-Fei Tian | 2022 | World Journal of Gastrointestinal Oncology2022，14，2： | 1 |
| 15 | Kinetic and thermodynamic studies on biosorption of Cu ( II ) by chemically modified orange peel 显示文摘 | Feng ning - chuan Guo xue- yi Liang sha | 2009 | Transactions of Nonfen:ous Metals Society of China2009，19，5： | 1 |
| 16 | A Preliminary Phylogenetic Analysis of Luidia (Paxillosida: Luidiidae) from Chinese Waters with Cytochrome Oxidase Subunit I (COI) Sequences显示文摘Luidia Forbes(Paxillosida: Luidiidae) are common soft bottom sea stars with 49 described species.Because of substantial morphological diversity,the taxonomy of the genus is complex and hasn't been resolved definitely.In order to resolve general taxonomic issues,and determine species boundaries and phylogenetic relationships within the genus Luidia,the sequences of cytochrome oxidase subunit Ι(COΙ) gene from 24 specimens of Luidia,belonging to eight taxa in Chinese waters,were studied.Three sequences of two species in genus Luidia from GenBank were used to analyze the phylogenetic relationships.The molecular phylogeny exhibited three main clades,each with strong bootstrap support: Clade A including Luidia quinaria from the Sea of Japan;Clade B including seven nominal species(L.quinaria von Martens,L.yesoensis Goto,L.changi Liu,Liao and Li,L.orientalis Fisher,L.avicularia Fisher,L.longispina Sladen and L.hardwicki Gray) from Chinese waters;and Clade C including L.maculata Müller & Troschel from Chinese waters.Our molecular phylogeny results support the morphological Quinaria-Group and Alternata-Group assigned by D derlein.Seven nominal species we sampled do not exhibit genetic distances that are large enough to recognize them as separate species.Cryptic species may exist in ‘Luidia quinaria' from the Yellow Sea and the Sea of Japan.Meaningful morphological characters need further investigation in Luidia. | XIAO Ning LIU Ruiyu YUAN Shuai SHA Zhongli | 2013 | Journal of Ocean University of China2013，12，3： | 0 |
| 17 | The Taxonomic Status of Japanese Threadfin Bream Nemipterus japonicus(Bloch, 1791)(Perciformes: Nemipteridae) with a Redescription of this Species from the South China Sea Based on Morphology and DNA Barcodes显示文摘Because of its importance as a food source, Nemipterus japonicus(Bloch, 1791)(Nemipteridae) or Japanese threadfin bream is the best studied of these taxa, and numerous investigations have examined its fisheries, its biology and biochemistry. Despite such intensive work, the taxonomic status of N. japonicus has never been seriously questioned and it is regarded as a common species, widely distributed throughout the Indo-Western Pacific Ocean. In fact, Bloch's description of the type specimen of N. japonicus has ambiguous collection data and lacks a designation for the type locality, though it is probably Java. In this paper, DNA barcode results based on COI gene support the existence of two geographically separated lineages of the Japanese threadfin bream, both being an Indian Ocean and western Pacific lineage, with 2.7% sequence divergence, and the results indicate a possible existing of some cryptic species. The two lineages also possess a diagnostic difference in their belly color, with specimens in the South China Sea having a silver belly, while those from the Indian Ocean isolate specimen have a yellow coloration. Based upon new collections from the South China Sea, this species from the western Pacific is morphologically redescribed and its details of DNA barcode diversity are shown for the future investigations. | NING Ping SHA Zhongli Paul D. N. HEBERT Barry RUSSELL | 2015 | Journal of Ocean University of China2015，14，1： | 0 |
| 18 | Simplified calculation of bile cholesterol saturation index显示文摘>Gallstones (cholelithiasis) are masses in the gallbladder or biliary tract that are caused by abnormally high levels of either cholesterol or bilirubin in bile [1]. It is a multifactorial disease and the main pathogenesis is the increased secretion of bile cholesterol,which can increase the cholesterol saturation index (CSI) of bile.Patients with CSI greater than 1 are more likely to develop gallstones.Bile is a kind of dark green to yellowish-brown liquid containing> 90% water.Cholesterol,lecithin and bile salts are the three main lipid species in bile and combined to form the main components of gallstones[1]. | Fen-Ming Zhang Xin Jiang Sha Li Long-Gui Ning Fang-Fang Guo Guo-Qiang Xu | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 0 |
| 19 | Executive summary of Chinese expert consensus for topical application of anti-microbial agents for lower respiratory tract infection in adults显示文摘In recent years,with the increased prevalence of multi-drug resistant(MDR)bacterial infection and chronic pulmonary infection,the topical application of anti-microbial agents,mainly inhaled antibiotics,has come back to clinical practice.Several formulations for nebulization and dry powder inhaler(DPI)have been approved for inhaled anti-infective therapy.Meanwhile,evidence and experience have been accumulated in the use of anti-microbial agents delivered via airway.However,the available studies in this field are heterogenous in the study population,drug delivery route and dosages.The efficacy and safety of inhaled anti-infective therapy in various types of lower respiratory tract infections(LRTIs)need to be evaluated.Moreover. | Jing Zhang Qijian Cheng Yi Huang Hong Fan Guoxiang Lai Xiangdong Mu Wei Sha Danyang She Ning Shen Xin Su Jinfu Xu Feng Ye Xinlun Tian Tiantuo Zhang Hua Zhou Youning Liu Lixian He Heping Xiao Bei He Yi Shi Xiangyan Zhang Bin Cao Jieming Qu on behalf of Pulmonary Infection Assembly of Chinese Thoracic Society | 2022 | Chinese Medical Journal2022，135，22： | 0 |
| 20 | Electrically driven single microwire-based single-mode microlaser显示文摘Engineering the lasing-mode oscillations effectively within a laser cavity is a relatively updated attentive study and perplexing issue in the field of laser physics and applications. Herein, we report a realization of electrically driven single-mode microlaser, which is composed of gallium incorporated zinc oxide microwire (ZnO:Ga MW) with platinum nanoparticles (PtNPs, d ~ 130 nm) covering, a magnesium oxide (MgO) nanofilm, a Pt nanofilm, and a p-type GaN substrate. The laser cavity modes could resonate following the whispering-gallery mode (WGM) among the six side surfaces by total internal reflection, and the single-mode lasing wavelength is centered at 390.5 nm with a linewidth of about 0.18 nm. The cavity quality factor Q is evaluated to about 2169. In the laser structure, the usage of Pt and MgO buffer layers can be utilized to engineer the band alignment of ZnO:Ga/GaN heterojunction, optimize the p-n junction quality and increase the current injection. Thus, the well-designed device structure can seamlessly unite the electron-hole recombination region, the gain medium, and optical microresonator into the PtNPs@ZnO:Ga wire perfectly. Such a single MW microlaser is essentially single-mode regardless of the gain spectral bandwidth. To study the single-mode operation, PtNPs working as superabsorber can engineering the multimode lasing actions of ZnO:Ga MWs even if their dimensions are typically much larger than that of lasing wavelength. Our findings can provide a straightforward and effective scheme to develop single-mode microlaser devices based on one-dimensional wire semiconductors. | Xiangbo Zhou Mingming Jiang Kai Xu Maosheng Liu Shulin Sha Shuiyan Cao Caixia Kan Da Ning Shi | 2022 | Light(Science & Applications)2022，11，8： | 0 |
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