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| 1 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders显示文摘The applicability of stable gut hormones for the treatment of obesity-related diabetes is now undisputable. This is based predominantly on prominent and sustained glucoselowering actions, plus evidence that these peptides can augment insulin secretion and pancreatic islet function over time. This review highlights the therapeutic potential of glucagon-like peptide-1(GLP-1), glucose-dependent insulinotropic polypeptide(GIP), oxyntomodulin(OXM) and cholecystokinin(CCK) for obesity-related diabetes.Stable GLP-1 mimetics have already been successfully adopted into the diabetic clinic, whereas GIP, CCK and OXM molecules offer promise as potential new classes of antidiabetic drugs. Moreover, recent studies have shown improved therapeutic effects following simultaneous modulation of multiple receptor signalling pathways by combination therapy or use of dual/triple agonist peptides. However, timing and composition of injections may be important to permit interludes of beta-cell rest. The review also addresses the possible perils of incretin based drugs for treatment of prediabetes. Finally, the unanticipated utility of stable gut peptides as effective treatments for complications of diabetes, bone disorders, cognitive impairment and cardiovascular dysfunction is considered. | Nigel Irwin Peter R Flatt | 2015 | World Journal of Diabetes2015，6，15： | 4 |
| 3 | Drug therapy for heart failure in older patients —what do they want?显示文摘长期的心失败(CHF ) 主要在更老的病人被看见,因此真实的生活药经常从在年轻得多的人口进行的试用要求调查结果的推测。规定模式和潜力受益在老被 polypharmacy 和 co 疾病的病理重重地影响。增加的长寿可以变得不太相关在脆弱老,而改善,生活(QoL ) 的质量经常成为优先级;在改进幸福上的义务,维持独立为更长,并且推迟 institutionalisation。与 CHF 评估老病人的特定的研究正在缺乏,很少关于 tolerability 和证据的副作用侧面被知道在这张人口的基于的药治疗。在有征兆的 CHF 的病人的心率的影响上有最近的兴趣。与降低能力的选择心率, Ivabradine 在湾穴节奏具有在有 CHF 和左室的收缩机能障碍的病人的利益,导致心失败 hospitalisation 和心血管的死亡的减小。这张手稿将集中于 CHF 和更老的病人并且将讨论心率,药治疗和 tolerability 的影响。它将也为集中于描述很治疗学的审判的集中病人的学习结束点而非死亡目标的特定的研究加亮未满足的需要。在介绍一个唯一的机会评估 tolerability 并且确定的治疗影响大量真实生活的 QoL 上评估 ivabradine 的影响的进行中的研究,有 CHF 的更老的病人将被讨论。 | Donah Zachariah Jacqueline Taylor Nigel Rowell Clare Spooner Paul R Kalra | 2015 | Journal of Geriatric Cardiology2015，12，2： | 2 |
| 4 | Parentage determination of Kuruma shrimp Penaeus (Marsupenaeus) japonicus using microsatellite markers (Bate)显示文摘 | DENA R J NIGEL P PRESTON P J | 2004 | Aquaculture2004，235，： | 1 |
| 5 | 'Green revolution' genes encode mutant gibberellin response modulators显示文摘 | Peng J R Donald E R Nigel M H | 1999 | Nature1999，400，： | 1 |
| 6 | Preoarati on of biodegradable insulin nanocapsules from biocompatible microemulsions显示文摘 | Suchat W Nigel M D Thomas R | 2000 | Pharm Res2000，17，6： | 1 |
| 7 | Increased mortality associated with growth hormone treatment in critically ill adults 显示文摘 | Esko R Nigel R | 1999 | N Engl J Med1999，341，： | 1 |
| 8 | The semantic grid:past,present and future显示文摘 | De Roure David Nicholas R Jennings Nigel R Shadbolt | 2005 | Proceeding of the IEEE2005，93，3： | 1 |
| 9 | Practical Fast Searching in Strings 显示文摘 | Nigel Horspool R | 1950 | Software Practice and Experience1950，10，6： | 1 |
| 10 | Precursors of nitrogenous disinfection by-products in drinking water-a critical review and analysis 显示文摘 | Tom Bond Michael R Templeton Nigel Graham | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 11 | Treatment of hypoxemia during Xylazine-Telazol immobilization of wapiti 显示文摘 | Matt R Read Nigel A | 2001 | Can Vet J2001，42，11： | 1 |
| 12 | Practical fast searching in strings显示文摘 | Nigel H R | 1980 | Software-Practice and Experience1980，10，： | 1 |
| 13 | Parentage determination of Kuruma shrimp Penaeus ( Marsupenaeus ) japonicus using microsatellite markers (Bate) 显示文摘 | Dena R J Nigel P P Peter J | 2004 | Aquaculture2004，235，： | 1 |
| 14 | A ferricchelatereductase for iron uptake from soils显示文摘 | Nigel J R Catherine M P Connolly E L | 1999 | Nature1999，397，69： | 1 |
| 15 | Ductility of squareconfined concrete columns 显示文摘 | Park R Nigel Priestley M J Gill W D | 1982 | Journal of the Structural Division ASCE1982，108，4： | 1 |
| 16 | Parentage determination of Kuruma shrimp Penaeus(Marsupenaeus)japonicus using microsatellite markers(Bate)显示文摘 | Dena R J Nigel P P Peter J | 2004 | Aquaculture2004，235，： | 1 |
| 17 | Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions显示文摘 | Suchat W Nigel M D Thomas R | 2000 | Pharm Res2000，6，： | 1 |
| 18 | Treatment of hypoxemia during Xylazine-Telazol immobilization of wapiti显示文摘 | Matt R Read Nigel A | 2001 | Can Vet J2001，42，11： | 1 |
| 19 | Customer Service:Differentiating by Market Segment显示文摘 | Peter Gilmour George Borg Peter A Duffy Nigel D Johnston B E Limbek Michael R Shaw | 1994 | International Journal of Physical Distribution & Logistics Management1994，24，4： | 1 |
| 20 | Marine downhole to seafloor dipole-dipole electromagnetic methods and the resolution of resistive targets显示文摘 | CARSTEN S R NIGEL EDWARDS | | 0，，02： | 1 |
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