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| 1 | Natural history of hepatic metastases from colorectal cancer-pathobiological pathways with clinical significance显示文摘Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process.This process starts with a series of mutations in colonic epithelial cells,continues with their detachment from the large intestine,dissemination through the blood and/or lymphatic circulation,attachment to the hepatic sinusoids and interactions with the sinusoidal cells,such as sinusoidal endothelial cells,Kupffer cells,stellate cells and pit cells.The metastatic sequence terminates with colorectal cancer cell invasion,adaptation and colonisation of the hepatic parenchyma.All these events,termed the colorectal cancer invasion-metastasis cascade,include multiple molecular pathways,intercellular interactions and expression of a plethora of chemokines and growth factors,and adhesion molecules,such as the selectins,the integrins or the cadherins,as well as enzymes including matrix metalloproteinases.This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting. | Konstantinos A Paschos Ali W Majeed Nigel C Bird | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 3 | Flavonol tetraglycosides and other constituents from leaves of Styphnolobiumjaponicum (Leguminosae) and related taxa显示文摘 | Geoffrey C Kite Charlotte A Sroneham Nigel C Veitch | 2007 | Phytochemistry2007，68，10： | 1 |
| 4 | Treatment of hypoxemia during Xylazine-Telazol immobilization of wapiti 显示文摘 | Matt R Read Nigel A | 2001 | Can Vet J2001，42，11： | 1 |
| 5 | Conducting polymers for neural interfaces: challenges in developing an effective long-term implant 显示文摘 | Rylie A Green Nigel H Lovell Gordon G Wallaee | 2008 | Biomateri- als2008，29，33： | 1 |
| 6 | The teratogenicity of methoxyacetic acid in the rat显示文摘 | BROWN NIGEL A HOLT D | 1984 | Toxicology Letters1984，22，1： | 1 |
| 7 | Treatment of hypoxemia during Xylazine-Telazol immobilization of wapiti显示文摘 | Matt R Read Nigel A | 2001 | Can Vet J2001，42，11： | 1 |
| 8 | Adhesion of thin coatings-the VAMAS (TWA 22-2) interlaboratory exercise显示文摘 | GILES A S NIGEL J JONATHAN H | 2005 | Surface and Coatings Technology2005，197，23： | 1 |
| 9 | Customer Service:Differentiating by Market Segment显示文摘 | Peter Gilmour George Borg Peter A Duffy Nigel D Johnston B E Limbek Michael R Shaw | 1994 | International Journal of Physical Distribution & Logistics Management1994，24，4： | 1 |
| 10 | Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha 7 nicotinic acetylcholine receptors 显示文摘 | Jensen A A Gharagozloo P Birdsall Nigel J | 2006 | Eur J Pharmacol2006，539，12： | 1 |
| 11 | Function and transcript analysis of gibberellin-biosynthetic enzymes in wheat显示文摘 | Nigel A Daniel E John L | 2006 | Planta2006，223，3： | 1 |
| 12 | Validation of a reversed-phase HPLC method for 1,1 0-phenanthroline-5,6-dione and analysis of its impurities by HPLC/MS显示文摘 | GHULAM A S NIGEL J F | 2003 | J Pharm Biomed Anal2003，33，： | 1 |
| 13 | Pharmacological characterization of strychnine and brucine analogues at glycine and α7 nicotinic acetylcholine receptors显示文摘 | Anders AJ Parviz G Nigel J M et a l | 2006 | European Journal of Pharamacology2006，539，： | 1 |
| 14 | SeismicTests of Precast Beam-to-Column Joint Subassem-blages With UnbondedTendons显示文摘 | Priestley M J Nigel Gregory A MacRae | | 0，，01： | 1 |
| 15 | Impaired skin microvascular reactivity in painful diabetic neuropathy显示文摘 | CRISTIAN Q RAYAZ A NIGEL D | 2007 | Diabetes Care2007，30，3： | 1 |
| 16 | Amount of water runoff from different vegetation types on extensive green roofs: Effects of plant species, diversity and plant structure显示文摘 | A yako N Nigel D | 2012 | Landscape and Urban Planning2012，104，： | 1 |
| 17 | Salesforce Performance and Behavior-based Management Processes in Business-to-Business Sales Organizations 显示文摘 | PIERCY NIGEL F CRAVENS DAVID W MORGAN NElL A | 1998 | European Journal of Marketing1998，32，12： | 1 |
| 18 | Biomolecular analysis of elastic fibre molecules 显示文摘 | Stuart A Caina Bertrand Raynala Nigel Hodsona | 2008 | Methods ExtracellMatr Res2008，45，1： | 1 |
| 19 | Advanced endoscopic imaging to im- prove adenoma detection 显示文摘 | Neumann H Nigel A Buda A | 2015 | World J Gastrointest Endosc2015，7，3： | 1 |
| 20 | Relationships between Sales Management Control, Territory Design, Salesforce Performance and Sales Organization Effectiveness显示文摘 | PIERCY NIGEL F CRAVENS DAVID W MORGAN NEIL A | 1999 | British Journal of Management1999，，10： | 1 |
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