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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 3 | Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol:a subgroup analysis of the BISO-CAD study显示文摘Background:Resting heart rate(RHR)is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients.Bisoprolol fumarate,a second-generation beta-adrenoreceptor blockers(β-blocker)is commonly prescribed drug to manage hypertension.The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease(CAD)patients from the CAD treated with bisoprolol(BISO-CAD)study who had comorbid hypertension.Methods::We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study(n=866),which was a phase IV,multination,multi-center,single-arm,observational study carried out from October 2011 to July 2015 across China,South Korea,and Vietnam.Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome(CCCO),the results were presented as adjusted odds ratio(OR)along with 95%confidence interval(CI)and adjusted P value.Results::A total of 681 patients(mean age:64.77±10.33 years)with hypertension from BISO-CAD study were included in the analysis.Bisoprolol improved CCCOs in CAD patients with comorbid hypertension,with RHR<65 and<70 beats/min compared with RHR≥65 and≥75 beats/min,respectively,in the efficacy analysis(EA)set.In addition,it lowered RHR in both intent-to-treat(ITT)and EA groups after 6,12,and 18 months of treatment.Further,RHR 70 to 74 beats/min resulted in significantly higher risk of CCCOs EA set of patients(adjusted OR:4.34;95%CI:1.19-15.89;P=0.03).Also,events of hospitalization due to acute coronary syndrome were higher when RHR 69 to 74 beats/min compared to RHR<69 beats/min in ITT patients.Conclusion::Bisoprolol can effectively reduce RHR in Asian CAD patients with comorbid hypertension and hence,improve CCCO without affecting their blood pressure. | Yun-Dai Chen Xin-Chun Yang Vinh Nguyen Pham Shi-An Huang Guo-Sheng Fu Xiao-Ping Chen Binh Quang Truong Yu Yang Shao-Wen Liu Tian-Rong Ma Dong-Soo Kim Tae-hoon Kim | 2020 | Chinese Medical Journal2020，，10： | 10 |
| 4 | Understanding bike trip patterns leveraging bike sharing system open data显示文摘 | Longbiao CHEN Xiaojuan MA Thi-Mai-Trang NGUYEN Gang PAN Jeremie JAKUBOWICZ | 2017 | Frontiers of Computer Science2017，11，1： | 2 |
| 5 | Superhydrophobic self-extinguishing cotton fabrics for electromagnetic interference shielding and human motion detection显示文摘Multifunctional intelligent fire-safe cotton fabric promises next-generation fire-fighting uniform and sen-sor applications.However,cotton fabrics’hygroscopicity and intrinsic flammability significantly impede their potential applications in industries.Herein,we report a superhydrophobic fireproof cotton fabric(PEI-APP-PEI-MXene)generated via sequential layer-by-layer deposition of polyethyleneimine(PEI),am-monium polyphosphate(APP),and titanium carbide(MXene),followed by hydrophobic treatment with silicone elastomer.Compared to untreated cotton,the treated cotton fabric with 10 polymolecular layers exhibits∼43%and∼42%reductions in the peak heat release rate and total heat release,respectively,a desired UL-94 V-0 rating,and a high limiting oxygen index(LOI)value of 39.5 vol.%.In addition to that,the treated fabrics displayed improved electromagnetic interference(EMI)shielding and motion-sensing abilities.The presented work provides a facile and effective surface modification approach to generate multifunctional cotton fabrics with promising practical applications. | Lei Liu Zhewen Ma Menghe Zhu Lina Liu Jinfeng Dai Yongqian Shi Jiefeng Gao Toan Dinh Thanh Nguyen Long-Cheng Tang Pingan Song | 2023 | Journal of Materials Science & Technology2023，，1： | 2 |
| 6 | Ligation ofintegrin alpha 3beta 1 by laminin 5 at the wound edge activates Rho-dependent adhesion of leading keratinocytes on collagen显示文摘 | Nguyen BP Ren XD Schwartz MA | 2001 | J Biol Chem2001，276，43： | 1 |
| 7 | Transcription factor rational design improves directed differentiation of human mesenchymal stem cells into skeletal myocytes 显示文摘 | Gonalves MA Janssen JM Nguyen QG | 2011 | Mol Ther2011，19，7： | 1 |
| 8 | Incidence and management of glaucoma after intravitreal silicon oil injection for complicated retinal detachments显示文摘 | Nguyen QH Lloyd MA Heuer DK | 1992 | Ophthalmology1992，99，10： | 1 |
| 9 | Self-synchronized synchronverters: Inverters without a dedicated synchronization unit显示文摘 | Qing-Chang Zhong Phi-Long Nguyen Zhenyu Ma | 2014 | IEEE Transactions on Power Electronics2014，29，2： | 1 |
| 10 | Acyclic cucurbit uril molecu|ar containers enhance the solubility and bioactivity of poor- ly soluble pharmaceuticals 显示文摘 | Ma D Hettiarachchi G Nguyen D | 2012 | Nat Chem2012，4，： | 1 |
| 11 | Early biomechanical wound failure:a mechanism for ventral incisional hernia formation显示文摘 | Franz MG Kuhn MA Nguyen K | 2001 | Wound Rep Reg2001，9，2： | 1 |
| 12 | Cost utility of tumour necrosis factor-α inhibitors for rheumatoid arthritis: an application of Bayesian methods for evidence synthesis in a Markov model 显示文摘 | NGUYEN CM BOUNTHAVONG M MENDES MA | 2012 | Pharmacoeconomics2012，30，7： | 1 |
| 13 | Overnight orthokeratology显示文摘 | Nichols JJ Marsich MM Nguyen M Barr JT Bullimore MA | | 0，，： | 1 |
| 14 | APP konekout mice exper- ence acute mortality as the result of ischemia 显示文摘 | Koike MA Lin A J Pham J Nguyen E | 2012 | PLos One2012，7，8： | 1 |
| 15 | Autism-associated mu-tation inhibits protein kinase C-mediated neuroligin-4X en-hancement of excitatory synapses显示文摘 | Bemben MA Nguyen QA Wang T | 2015 | Proc Natl Acad Sci USA2015，112，8： | 1 |
| 16 | A metal-organic framework material that functions as an enantioselective catalyst for olefin epoxidation显示文摘 | Cho S H Ma B Nguyen S T | 2006 | Chem Comm2006，，： | 1 |
| 17 | Incidence and management of glaucoma after intravitreal silicone oil injection for complicated retina detachment显示文摘 | Nguyen QH Lioyd MA Heuer DK | 1992 | Ophthalmology1992，99，： | 1 |
| 18 | Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis显示文摘 | Nguyen TP Casarin A Desbats MA Doimo M Trevisson E Santos-Ocana C | 2014 | Biochim Biophys Acta2014，1841，： | 1 |
| 19 | High ionic conductivity P(VBF-TrFE)/PEO blended polymer electrolytes for solid electrochromic devices显示文摘 | Nguyen C A Xiong S Ma J | 2011 | Physical Chemistry Chemical Physics2011，13，13： | 1 |
| 20 | Inducible activation of oncogenic K-ras results in tumour formation in theoral cavity 显示文摘 | Caulin C Nguyen T Longley MA | 2004 | Cancer Res2004，64，15： | 1 |
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