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| 1 | Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive显示文摘AIM: To determine the changes of quantitative hepatitis B e antigen (HBeAg) that predicts early detection of non- response or breakthrough to long-term lamivudine (LAM) therapy.METHODS: Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 mo, we retrospectively analyzed 220 patients who had received LAM more than 24 mo. RESULTS: The mean duration of LAM therapy was 36 (range, 24-72) mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 (24.1%) patients. Viral breakthrough was observed in 105 (47.7%) patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg: decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non- response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 (92.5%) of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four (7.5%) had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 mo, 95.2% (negative predictive value) failed to achieve HBeAg seroconversion.CONCLUSION: Almost all patients who failed to showa continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough. | Jung Woo Shin Neung Hwa Park Seok Won Jung Byung Chul Kim Sung Ho Kwon Jae Serk Park In Du Jeong Sung-Jo Bang Do Ha Kim | 2006 | World Journal of Gastroenterology2006，12，41： | 7 |
| 2 | A gastrointestinal stromal tumor of the duodenum masquerading as a pancreatic head tumor显示文摘Gastrointestinal stromal tumor (GIST) represents the most common kind of mesenchymal tumor that arises from the alimentary tract. GIST is currently defined as a gastrointestinal tract mesenchymal tumor showing CD117 (c-kit protein) positivity at immunohistochemistry. Throughout the whole length of the gastrointestinal tract, GIST arises most commonly from the stomach followed by the small intestine, the colorectum, and the esophagus. Only 3%-5% of GISTs occur in the duodenum, and especially, if GIST arises from the C loop of the duodenum, it can be difficult to differentiate from the pancreas head mass because of its anatomical proximity. Here, we report a case of duodenal GIST, which was assessed as a pancreatic head tumor preoperatively. | Sung Ho Kwon Hee Jeong Cha Seok Won Jung Byung Chul Kim Jae Serk Park In Du Jeong Jong Hwa Lee Yang Won Nah Sung Jo Bang Jung Woo Shin Neung Hwa Park Do Ha Kim | 2007 | World Journal of Gastroenterology2007，13，24： | 4 |
| 3 | Metastasis of hepatocellular carcinoma to the small bowel manifested by intussusception显示文摘肝细胞癌(HCC ) 是造血地并且 lymphogenously 转移到远地点的一个高度侵略的肿瘤。经常的地点是肺,地区性的淋巴节点,骨头,和肾上腺。但是转移到胃肠(官方补给) 道稀罕、很普通地点胃。到小肠的转移是极其稀罕的。而且,引起摄取的小肠的变形 HCC 没被报导直到现在。这里,我们向摄取表明的小肠汇报 HCC 的转移的一个案例。 | Hyun Soo Kim Jung WooShin In Du Jeong Sung-Jo Bang Do Ha Kim Neung Hwa Park Gyu Yeol Kim Young Min Kim Hee Jeong Cha Yoong Ki Jeong | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 4 | Effect of plant growth promoting rhizobacteria (PGPR) inoculation on microbial community structure in rhizosphere of forage corn cultivated in Thailand显示文摘 | Pongdet Piromyou Bancha Buranabanyat Piyada Tantasawat Panlada Tittabutr Nantakorn Boonkerd Neung Teaumroong | 2010 | European Journal of Soil Biology2010，，1： | 2 |
| 5 | Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea显示文摘AIM: To establish the role of FHIT in the pathogenesis hepatocellular carcinoma (HCC). METHODS: We examined genomic alterations, as well as, mRNA and protein expression patterns from the FHIT gene, in 48 surgically resected hepatocellular carcinoma (HCC) tissues. Additionally, p53 mutations were analyzed. RESULTS: Aberrant FHIT transcripts were detected in 11 of 48 surrounding non-tumor liver tissues and 27 of 48 HCC samples (22.9% vs 56.3%, P = 0.002). No point mutations were identified within the open reading frame region of FHIT. Loss of heterozygosity (LOH) of the FHIT locus was detected in 4 of 42 informative cases for D3S1300, and 3 of 29 informative cases for D3S1313. Reduced expression of FHIT protein (Fhit) was observed in 8 (16.7%) of 48 HCC samples, with complete loss of Fhit in only 1 case. There were no associations with abnormal transcripts, LOH, and Fhit expression. p53 mutations were identified in 9 of the 48 HCC cases. However, none of the cases displayed a G to T transversion at p53 codon 249. CONCLUSION: Aberrant FHIT transcripts were more common in HCC tissues as compared to non-cancerous liver tissues. However, Fhit expression was lost or reduced in a minor fraction of HCC tissues, while it was strongly expressed in non-cancerous liver tissues.Therefore, our study suggests that FHIT plays a role in relatively few HCC cases in South Korea. | Chang Woo Nam Jung Woo Shin Neung Hwa Park | 2008 | World Journal of Gastroenterology2008，14，22： | 2 |
| 6 | Nationwide seroepidemiology of hepatitis B virus infection in South Korea in 2009 emphasizes the coexistence of HBsAg and anti‐HBs显示文摘 | Byung Seok Lee Yong Kyun Cho Sook‐Hyang Jeong Joon Hyeok Lee Don Lee Neung Hwa Park Moran Ki | 2013 | Virol2013，，8： | 1 |
| 7 | Effect of plant growth promoting rhizobacteria (PGPR) inoculation on microbial community structure in rhizosphere of forage corn cultivated in Thailand显示文摘 | Pongdet Piromyou Bancha Buranabanyat Piyada Tantasawat Panlada Tittabutr Nantakorn Boonkerd Neung Teaumroong | 2010 | European Journal of Soil Biology2010，，1： | 1 |
| 8 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
| 9 | Modification of cationic nanoclys with inonic liquids显示文摘 | Kim Neung Hyun Malhotra Sabjay V Marino Xanthos | 2006 | Microporous and Mesoporous Materials2006，96，： | 1 |
| 10 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
| 11 | Clinical course of patients with insufficient viral suppression during entecavir therapy in genotype C chronic hepatitis B显示文摘 | Sung-Jo Bang Byung Gyu Kim Jung Woo Shin Hyeong Uk Ju Bo Ryung Park Min-Ho Kim Chang Jae Kim Jae Ho Park In Du Jeong Seok Won Jung Neung Hwa Park | 2013 | Digestive and Liver Disease2013，，7： | 1 |
| 12 | Impacts of Vaccination on Hepatitis B Viral Infections in Korea over a 25-Year Period显示文摘 | Park Neung Hwa Chung Young-hwa Lee Hyo-suk | 2010 | Intervirology2010，，1： | 1 |
| 13 | Cassava as a Cheap Source of Carbon for Rhizobial Inoculant Production using an Amylase-producing Fungus and a Glycerol-producing Yeast显示文摘 | Panlada Tittabutr Waraporn Payakapong Neung Teaumroong Nantakorn Boonkerd | 2005 | World Journal of Microbiology and Biotechnology (-)2005，，6： | 1 |
| 14 | Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: Possible implications on survival显示文摘 | Seok Won Jung Neung Hwa Park Jung Woo Shin Bo Ryung Park Chang Jae Kim Jong-Eun Lee Eun-Soon Shin Jeong A Kim Young-Hwa Chung | 2012 | Journal of Hepatology2012，，3： | 1 |
| 15 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
| 16 | Modification of cationic nanoclays with ionic liquids 显示文摘 | NEUNG HYUN KIM SAN JAY V MALHOTRA MARINO XANTHOS | 2006 | Micro Meso Mater2006，96，13： | 1 |
| 17 | A nationwide seroepidemiology of hepatitis C virus infection in South Korea显示文摘 | Do Young Kim In Hee Kim Sook‐Hyang Jeong Yong Kyun Cho Joon Hyoek Lee Young‐Joo Jin Don Lee Dong Jin Suh Kwang‐Hyub Han Neung Hwa Park Ha Yan Kang Young Kul Jung Young Seok Kim Kyung‐Ah Kim Youn Jae Lee Byung Seok Lee Hyung Joon Yim Heon Ju Lee Soon Koo B | 2013 | Liver Int2013，，4： | 1 |
| 18 | Applications of LC/ESI- MS/MS and UHPLC QqTOF MS for the Determination of 148 Pesticides in Fruits and Vegetables显示文摘 | WANG Jian CHOW W NEUNG D | 2010 | Analytical and Bioanalytical Chemistry2010，396，4： | 1 |
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