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| 1 | Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients. | José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 2 | 成人原发结肠嗜酸性粒细胞增多症及嗜酸性结肠炎显示文摘目前,正常成人结肠黏膜中嗜酸性粒细胞数量以及嗜酸性结肠炎的组织学诊断标准尚未明确。本文为明确正常成人结肠黏膜中嗜酸性粒细胞数量,构建了原发结肠嗜酸性粒细胞增多症及嗜酸性结肠炎的临床病理诊断框架,对159名健康成人的左半结肠、横结肠以及右半结肠黏膜的嗜酸性粒细胞进行计数,并从120万例结肠活检病例的资料库里,提取诊断为结肠嗜酸性粒细胞增多症的成年患者资料,除复习所有病理切片外,并获取相关人口统计学信息、临床病理资料以及患者其它器官嗜酸性粒细胞增多症的信息。 | Turner K O Sinkre R A Neumann W L 尤晓萍 余英豪 | 2017 | 临床与实验病理学杂志2017，33，1： | 3 |
| 3 | DVT and pulmonary embolism after acute infection 显示文摘 | Neumann V O'Connor R J Bhakta BB | 2006 | Lancet2006，368，9531： | 1 |
| 4 | Pulmonary vein diameter reduction after radiofrequency catheter ablation for paroxysmal atrial fibrillation evaluated by contrast-enhanced three-dimensional magnetic resonance imaging显示文摘 | Dill T Neumann T Ekinci O | 2003 | Circulation2003，107，6： | 1 |
| 5 | Microglia provide neuroprotection after ischemia显示文摘 | Neumann J Gunzer M Gutzeit H O | 2006 | FASEB J2006，20，6： | 1 |
| 6 | Plmonary vein diameter reduction after radiofrequency catheter ablation for paroxysmal atrial fibrillation evaluated by contrast-enhanced three-dimensional magnetic resonance imaging显示文摘 | Dill T Neumann T Ekinci O | 2003 | Circulation2003，107，7： | 1 |
| 7 | Acetylcholine receptor gene expression in experimental autoimmune myasthenia gravis显示文摘 | Asher O Neumann D Witzemann V | 1990 | FEBS Letters1990，267，： | 1 |
| 8 | Reconstruction of high-energy bremsstrahlung spectra by numerical analysis of depth- dose data显示文摘 | Sauer O Neumann M | 1990 | Radiother Oncol1990，18，1： | 1 |
| 9 | Puttiny the spind crod together again显示文摘 | Behar O Mizuno K Neumann S | 2000 | Neuron2000，26，2： | 1 |
| 10 | Vasopressin released within the central amygdala promotes maternal aggression 显示文摘 | Bosch O J Neumann ID | 2010 | Eur J Neurosei2010，31，5： | 1 |
| 11 | Clustering of Features of Von Hippel-Lindau Syndrome: Evidence for a Complex Genetic Locus 显示文摘 | Neumann H P H Wiestler O D | 1991 | Lancet1991，337，： | 1 |
| 12 | Root excretion of carboxylic acids and protons in phosphorus-deficient plants显示文摘 | Neumann G R(o)mheld V | 1999 | Plant Soil1999，211，1： | 1 |
| 13 | An efficient, catalytic, aerobic, oxidative iodination of arenes using the HsPV2Mol004o polyoxometalate as catalyst 显示文摘 | Branytska O V Neumann R | 2003 | J Org Chem2003，68，24： | 1 |
| 14 | Pulmonary vein diameter reduction after radiofrequency catheter ablation for paroxysmal atrial fibrillation evaluated by contrast-enhanced three-dimensional magnetic resonance imaging显示文摘 | Dill T Neumann T Ekinci O | 2003 | Circulation2003，107，6： | 1 |
| 15 | The incidence of Frey syndrome following parotidectomy: results of a survey and foilowup 显示文摘 | Neumann A Rosenberger D Vorsprach O | 2011 | HNO2011，59，2： | 1 |
| 16 | Donor-recipient sex matching and posttransplant malignancies after induction therapy in hepatic transplantation显示文摘 | Jonas S Neumann U Guckelberger O | 1998 | Transplant Proc1998，30，4： | 1 |
| 17 | Root excretion of carboxylic acids and protons in phosphorus-deficient plants显示文摘 | Neumann G R O mheld V | 1999 | Plant and Soil1999，211，： | 1 |
| 18 | How does Armeria maritima tolerate high heavy metal concentrations显示文摘 | NEUMANN D NIEDEN U Z LICHTENBERGER O | 1995 | Journal of Plant Physiology1995，146，： | 1 |
| 19 | Mars:Northern hemisphere slopes and slope distributions显示文摘 | Aharonson O Zobar M T Neumann G A | 1998 | Geophys Res Lett1998，25，24： | 1 |
| 20 | Heat-shock proteins induce heavy-metal tolerance in higher plants 显示文摘 | NEUMANN D LICHTENBERGER O GUNTHER D | 1994 | Planta1994，194，： | 1 |
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