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| 1 | Ileal pouch surgery for ulcerative colitis显示文摘Ulcerative colitis (UC) is a relapsing and remitting disease characterised by chronic mucosal and submucosal inflammation of the colon and rectum. Treatment may vary depending upon the extent and severity of inflammation. Broadly speaking medical treatments aim to induce and then maintain remission. Surgery is indicated for inflammatory disease that is refractory to medical treatment or in cases of neoplastic transformation. Approximately 25% of patients with UC ultimately require colectomy. Ileal pouch-anal anastomosis (IPAA) has become the standard of care for patients with ulcerative colitis who ultimately require colectomy. This review will examine indications for IPAA, patient selection, technical aspects of surgery, management of complications and long term outcome following this procedure. | Simon P Bach Neil J Mortensen | 2007 | World Journal of Gastroenterology2007，13，24： | 10 |
| 2 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Is cardiac resynchronisation therapy feasible, safe and beneficial in the very elderly?显示文摘ObjectiveTo evaluate 心脏的同一时刻治疗(CRT ) 培植是否与经历 CRT 培植的 symptoms.MethodsConsecutive 病人一起在 octogenarians 和协会可行、安全,从二个英国中心被招募。根据年龄组织的病人:<80 &≥80 年。基线人口分布,复杂并发症和结果在 439 个病人的那些 groups.ResultsA 总数之间被比较在这研究, 26%≥ 是谁被包括;80 年。Octogenarians 更经常与心脏的同一时刻治疗使用高压脉冲来消减心脏相比收到了心脏的再同步治疗心律调整器。从心律调整器的升级在两个组是普通的(16%<80 年对 22%≥80 年, P = NS ) 。合作病态在两个组是同样普通的(全面糖尿病:25% , atrial 纤维性颤动:23% ,高血压:45%) 。更耐心的年龄 ≥80 年有重要的长期的肾疾病(CKD,估计的 glomerular 过滤率 <45 mL/min 每 1.73 m 2,44% 对 22% , P <0.01 ) 。全面复杂并发症率(任何东西) 在两个组是类似的(16% 对 17% , P = NS ) 。两个组表明了征兆的利益。一个年死亡率作为与更年轻的队相比是在 octogenarians 更大的几乎四褶层(13.9% 对 3.7% , P <0.01 ).ConclusionsCRT 看起来安全在尽管有广泛的合作病态老、特别地经常严重 CKD。征兆的改进看起来有意义。增加的策略是 CRT 的潜在的候选人的有 CHF 的老病人的适当鉴定被要求。 | Bartosz Olechowski Rebecca Sands Donah Zachariah Neil P Andrews Richard Balasubramaniam Mark Sopher John Paisey Paul R Kalra | 2015 | Journal of Geriatric Cardiology2015，12，5： | 5 |
| 4 | Waste biomass from production process co-firing with coal in a steam boiler to reduce fossil fuel consumption:A case study显示文摘Waste biomass is always generated during the production process in industries.The ordinary way to get rid of the waste biomass is to send them to landfill or burn it in the open field.The waste may potentially be used for co-firing with coal to save fossil fuel consumption and also reduce net carbon emissions.In this case study,the bio-waste from a Nicotiana Tabacum(NT) pre-treatment plant is used as the biomass to co-fire with coal.The samples of NT wastes were analysed.It was found that the wastes were of the relatively high energy content which were suitable for co-firing with coal.To investigate the potential and benefits for adding NT wastes to a Fluidised Bed Combustion(FBC) boiler in the plant,detailed modelling and simulation are carried out using the European Coal Liquefaction Process Simulation and Evaluation (ECLIPSE) process simulation package.The feedstock blending ratios of NT waste to coal studied in this work are varied from 0%to 30%. The results show that the addition of NT wastes may decrease the emissions of CO2 and SOx without reducing the boiler performance. | Hongyan Gu Kai Zhang Yaodong Wang Ye Huang Neil Hewitt Anthony P Roskilly | 2013 | Journal of Energy Chemistry2013，22，3： | 3 |
| 5 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 6 | 《一个包容性城市的远景》——华盛顿市民参与公共决策的案例显示文摘<一个包客性城市的远景>是对哥伦比亚特区(即美国首都华盛顿市)的67平万英里地域所做的综合性远景规划,该项目从2003年至2004年历时一年.华盛顿市市长威廉姆斯和哥伦比亚特区规划办公室首倡这一课题,目的是要澄清市长对美国首都未来的构想,并对特区各阶层居民的需求和所关心的问题做出反应. | Neil·P·Kittredge 王玉 | 2004 | 北京规划建设2004，，5： | 2 |
| 7 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 8 | Rapid and robust slope failure appraisal using aerial photogrammetry and 3D slope stability models显示文摘Slope failures are an inevitable aspect of economic pit slope designs in the mining industry.Large open pit guidelines and industry standards accept up to 30%of benches in open pits to collapse provided that they are controlled and that no personnel are at risk.Rigorous ground control measures including real time monitoring systems at TARP(trigger-action-response-plan)protocols are widely utilized to prevent personnel from being exposed to slope failure risks.Technology and computing capability are rapidly evolving.Aerial photogrammetry techniques using UAV(unmanned aerial vehicle)enable geotechnical engineers and engineering geologists to work faster and more safely by removing themselves from potential line-of-fire near unstable slopes.Slope stability modelling software using limit equilibrium(LE)and finite element(FE)methods in three dimensions(3D)is also becoming more accessible,user-friendly and faster to operate.These key components enable geotechnical engineers to undertake site investigations,develop geotechnical models and assess slope stability faster and in more detail with less exposure to fall of ground hazards in the field.This paper describes the rapid and robust process utilized at BHP Limited for appraising a slope failure at an iron ore mine site in the Pilbara region of Western Australia using a combination of UAV photogrammetry and 3D slope stability models in less than a shift(i.e.less than 12 h). | Neil Bar Michael Kostadinovski Michael Tucker Glen Byng Rully Rachmatullah Arturo Maldonado Markus Pötsch Andreas Gaich Alison McQuillan Thamer Yacoub | 2020 | International Journal of Mining Science and Technology2020，30，5： | 2 |
| 9 | Catalase HPII from Escherichia coli Exhibits Enhanced Resistance to Denaturation显示文摘 | Switala J O'Neil J O Loewen P C | 1999 | Biochemistry1999，38，13： | 1 |
| 10 | The value of the world’s ecosystemservices and natural capita1显示文摘 | Costanza R Arge R Groot R Farberk S Grasso M HannonB Limburg K Naeem S O’Neil R Paruelo J Raskin R Suttonkk P &Belt M | 1997 | Nature1997，387，： | 1 |
| 11 | Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu显示文摘 | NEIL S J ZANG T BIENIASZ P D | 2008 | Nature2008，451，7177： | 1 |
| 12 | Overriding imatinib resistance with a novel Abl kinase inhibitor显示文摘 | Neil P Shah Chris Tran Francis Y Lee | 2004 | Science2004，305，： | 1 |
| 13 | Salinity effects on the microwave emission of soil显示文摘 | Jackson T J O'Neil P E | 1990 | Remote Sens Environ1990，31，： | 1 |
| 14 | FBW7 mutations in leukemic ceils mediate NOTCH pathway activation and resistance to gamma- secre-tase inhibitors 显示文摘 | O' Neil J Grim J Strack P | 2007 | Exp Med2007，204，8： | 1 |
| 15 | Diffusion tensor imaging of normal and injured developing human brain显示文摘 | MiUer J Mukherjee P | 2002 | NMR Biomed2002，15，： | 1 |
| 16 | An operational system for Generating cloud drift winds in the Australian region and their impaction numerical weather prediction显示文摘 | John L Neil P Bob S | 1994 | American Meteorology Society1994，9，6： | 1 |
| 17 | Recombinant chicken IFN-γ expressed in Escherichia coli: Analysis of C-terminal truneation and effeet on biologie aetivity显示文摘 | Miehalski W P Shiell B J O'Neil T E | 1999 | Journal of Interferon & Cytokine Researeh1999，19，4： | 1 |
| 18 | Comparison Between IEEE and CIGRE Ampacity Standards显示文摘 | NEIL P S | 1999 | IEEE Transactions on Power Delivery1999，14，4： | 1 |
| 19 | Requirement of borate cross-linking of cell wall rhamnogalacturonanⅡfor Arabidopsis growth 显示文摘 | O'Neil M A Eberhard S Albersheim P | 2001 | Science2001，294，5543： | 1 |
| 20 | Force calibration in lateral force microscopy显示文摘 | Robert G Cain S B Neil W P | 2000 | Journal of colloid and interface science2000，227，： | 1 |
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