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| 1 | STUDY OF THE FLOWTHROUGH NON-SUBMERGED VEGETATION显示文摘Vegetation is an important feature of many rivers. Vegetation along rivers produces high resistance to flow and, as a result, has a large impact on water levels in rivers and lakes. The effects of instream-unsubmerged vegetat ion (such as the reed-similar Kalmus) on flow resistance and velocity distribut ions is studied in the paper. Artificial vegetation is used in the experimental study to simulate the Acorus Calmus L. As shown in experimental tests the re sist ance depends strongly on vegetation density and the Manning resistance coef ficient varies with the depth of flow. A simplified model based on concepts of d rag is developed to evaluate the roughness coefficient (Manning’s n) for no n-submerged vegetation. In vegetated channels the overall flow resistance is in fluenced significantly by the distribution pattern of the vegetated beds. Within vegetation, vertical variation in velocity is different from that in the non-v egetated bed, which reflects the variation in vegetation density. Vertical turbu lent transport of momentum is negligible as demonstrated by experiments. | NEHAL Laounia YAN Zhong-min XIA Ji-hong | 2005 | Journal of Hydrodynamics2005，17，4： | 14 |
| 2 | Circulating tumor and cancer stem cells in hepatitis C virusassociated liver disease显示文摘AIM:To assess the role of circulating tumor cells(CTCs)and cancer stem cells(CSCs)in hepatitis C virus(HCV)-associated liver disease.METHODS:Blood and/or tissue samples were obtained from HCV(genotype 4)-associated hepatocellularcarcinoma patients(HCC;n=120),chronic hepatitis C patients(CH;n=30)and 33 normal control subjects(n=33).Serum levels of alpha-fetoprotein(AFP),alkaline phosphatase,and alanine and aspartate aminotransferases were measured.Cytokeratin 19(CK19)monoclonal antibody was used to enumerate CTCs,and CD133 and CD90 were used to enumerate CSCs by flow cytometry.The expression levels of the CSCs markers(CD133 and CD90)as well as telomerase,melanoma antigen encoding gene 1(MAGE1)and MAGE3 were assessed by RTPCR and quantitative real-time polymerase chain reactions.The number of CTCs and/or the expression levels of CK19,CD133,telomerase,MAGE1 and MAGE3 were correlated to the standard clinicopathologic prognostic factors and disease progression.RESULTS:Levels of AFP,alkaline phosphatase and aspartate aminotransferase were significantly different among the HCC,CH and control groups(P<0.001),whereas alanine aminotransferase differed significantly between patient(HCC and CH)and control groups(P<0.001).At the specified cutoff values determine by flow cytometry,CK19(49.8),CD90(400)and CD133(73)were significantly higher in the blood of HCC patients compared to those in the CH and control groups(P<0.001).On the other hand,CD133 at a 69.5 cutoff was significantly higher in the CH compared to the control group(P≤0.001).Telomerase,MAGE1 and MAGE3RNA were expressed in 55.71%,60.00%and 62.86%of the HCC patients,respectively,but were not detected in patients in the CH or control groups,which were statistically significant(Ps<0.001).The expression levels of telomerase,CD90,MAGE3,CD133 and CK19 were all significantly associated with high tumor grade and advanced stage in HCC patients(all P s<0.05).CONCLUSION:CTC counts and AFP,CK19,telomerase,and MAGE1/MAGE3 expression predict disease progression in patients with HCV,whereas telomerase,MAGE3,CD90,CD133 and CK19 are prognostic mark- | Abeer A Bahnassy Abdel-Rahman N Zekri Ahmed El-Bastawisy Amal Fawzy Marwa Shetta Nehal Hussein Dalia Omran Abdallah A S Ahmed Samir S El-Labbody | 2014 | World Journal of Gastroenterology2014，20，48： | 9 |
| 3 | Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy显示文摘AIM:To undertake a baseline study comparing quality of life(QoL) in patients with chronic pancreatitis(CP) on Antox to those with CP,matched for disease duration,who were not on this medication.METHODS:CP was defined according to the Zurich classification.Sixty eight consecutive patients with CP who were taking Antox(antioxidants) were compared with 69 consecutive control CP patients not on Antox.European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core questions 30 and Pancreatic Modification(28 questions) were used to assess QoL.Out of a total of 137 patients 28 in each group were matched for disease duration(within 12 mo).Median disease duration was 8(1-22) years in the Antox group and 7(1-23) years in the Non-Antox cohort(P = NS,Mann-Whitney U-test).Other parameters(age,gender,etiology,endocrine and exocrine insufficiency) were similar between groups.RESULTS:Median visual analogue pain score in the Antox group was 3(0-8) compared with 6(0-8) in the Non-Antox group(P < 0.01).Perceptions of cognitive,emotional,social,physical and role function were impaired in the Non-Antox group compared to Antox patients(P < 0.0001,P = 0.0007,P = 0.0032 and P < 0.005 and P < 0.001,respectively).Analgesics and opiate usage was significantly lower in the Antox group(P < 0.01).Overall physical health and global QoL was better in the Antox group(P < 0.0001,95% CI:1.5-3).CONCLUSION:Contemporary quality of life assessments show that after correction for disease duration and cigarette smoking,patients with CP taking antox had better scores than non-antox controls. | Nehal S Shah Alistair J Makin Aali J Sheen Ajith K Siriwardena | 2010 | World Journal of Gastroenterology2010，16，32： | 4 |
| 4 | 美国放射学院适宜性标准:肩关节置换术后影像学检查(续)显示文摘过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分。第一部分阐述了对各种影像学检查模式的总体探讨,包括X线片、计算机断层扫描、核磁共振成像、超声、核医学以及它们提供有益的以治疗为导向的信息时所发挥的作用。第二部分重点研究最佳影像学方法的选择,用于肩关节置换术的并发症,包括无菌性松动、感染、骨折、肩袖肌腱撕裂和神经损伤。在本报告中所提供的美国放射学院适宜性标准循证指南,是通过广泛分析来自同行评审期刊的现有医学文献,并应用行之有效的方法学而完成的(兰德/加州大学洛杉矶分校的适宜性方法以及推荐评价、发展和评估分级),它们用于特殊临床情况下的影像学检查和治疗措施的适宜性评价。多学科专家小组对指南进行了进一步的分析和审查。由于用于推荐合适成像算法的数据会出现不足或模棱两可,在这种情况下,专家意见可能对现有证据进行补充。为此,将美国《放射学院适宜性标准:肩关节置换术后影像学检查》翻译成中文,供同道参考。 | 张晓萌 陈建海 Soterios Gyftopoulos Zehava S.Rosenberg Catherine C.Roberts Jenny T.Bencardino Marc Appel Steven J.Baccei R.Carter Cassidy Eric Y.Chang Michael G.Fox Bennett S.Greenspan Mary G.Hochman Jon A.Jacobson Douglas N.Mintz Joel S.Newman Nehal A.Shah Kirstin M.Small Barbara N.Weissman | 2017 | 中华肩肘外科电子杂志2017，5，4： | 2 |
| 5 | Formation of fluid heavy oil-in-water emulsions for pipeline transportationt显示文摘 | Nehal S A Amal M N Nael N Z | 1999 | Fuel1999，78，59： | 1 |
| 6 | Lubricating Oil Additives Based on Polyalkylpolyamines显示文摘 | Nehal S. Ahmed Amal M. Nassar | 2009 | International Journal of Polymeric Materials2009，，3： | 1 |
| 7 | Use of ex vivo confocal scanning laser microscopy during Mohs surgery for nonmelanoma skin cancers显示文摘 | Chung VQ Dwyer PJ Nehal KS | 2004 | Dermatol Surg2004，30，12： | 1 |
| 8 | The second brain in Parkinson’s disease: fact or fantasy?显示文摘Parkinson’s disease(PD)is a movement disorder characterized by reduced dopamine levels due to degeneration of the substantia nigra.The clinical presentation is underlined by bradykinesia,postural instability,and tremors.PD is the second most common neurodegenerative disease worldwide,with a huge monetary burden.In the United States alone,it is estimated that in 2017,the total economic cost was$51.9 billion,and projected to surpass$79 billion by 2037.Extensive research has been conducted into the pathophysiology and clinical implications of the disease.Within neurodegenerative disorder itself,the entity involving the brain-gut axis has been a fundamental model in understanding the disease process.More so than ever in PD,the association between gut health and neurological disease is gaining momentum,with the fascinating idea of influencing neurological health by treating the gut. | Nehal Yemula Paul Njoku Joseph Takyi | 2022 | Neural Regeneration Research2022，17，8： | 1 |
| 9 | Skin imaging with reflectance confocal microscopy显示文摘 | Nehal KS Gareau D Rajadhyaksha M | 2008 | Semin Cutan Med Surg2008，27，1： | 1 |
| 10 | Phenolics of selected lentil cultivars: Antioxidant activities and inhibition of low-density lipoprotein and DNA damage显示文摘 | Nehal Alshikh Adriano Costa de Camargo Fereidoon Shahidi | 2015 | Journal of Functional Foods2015，，： | 1 |
| 11 | Erythromelalgia precipitated by acral erythema in the setting of thrombocytopenia 显示文摘 | Coppa LM Nehal KS Young JW | 2003 | J Am Acad Dermatol2003，48，6： | 1 |
| 12 | Alterations of the CD4 + , CD8 + , T cell subsets, interleukins -6, IL - 10, IL - 17,tumor necrosis factor-eL and soluble intercellular ad- he sion molecule-1 in rheumatoid arthritis and osteoarthri- tis :preliminary observations 显示文摘 | Mahmoud R Nehal A Fathi B | 2008 | Pathol Oncol Res2008，14，3： | 1 |
| 13 | Histologic distinction between subungual lentigo and melanoma显示文摘 | Amin B Nehal KS Jungbluth AA | 2008 | Am J Surg Pathol2008，32，6： | 1 |
| 14 | Use of ex vivo confocal scanning laser microscopy during Mohs surgery for nonmelanoma skin cancers显示文摘 | Chung VQ Dwyer PJ Nehal KS ct al | 2004 | Dermatol Surg2004，30，121： | 1 |
| 15 | Risk scoring model for prediction of non-home discharge after transcatheter aortic valve replacement显示文摘Background Patients undergoing transcatheter aortic valve replacement(TAVR) are likely to be discharged to a location other than home. We aimed to determine the association between preoperative risk factors and non-home discharge after TAVR. Methods Patients discharged alive after TAVR at three centers were identified from a prospectively maintained database randomly divided into 80% derivation and 20% validation cohorts. Logistic regression models were fit to identify preoperative factors associated with non-home discharge in the derivation cohort. Multivariable models were developed and a nomogram based risk-scoring system was developed for use in preoperative counseling. Results Between June 2012 and December 2018, a total of 1,163 patients had TAVR at three centers. Thirty-seven patients who died before discharge were excluded. Of the remaining 1,126 patients(97%) who were discharged alive, the incidence of non-home discharge was 25.6%(n = 289). The patient population was randomly divided into the 80%(n = 900) derivation cohort and 20%(n = 226) validation cohort. Mean ± SD age of the study population was 83 ± 8 years. In multivariable analysis, factors that were significantly associated with non-home discharge were extreme age, female sex, higher STS scores, use of general anesthesia, elective procedures, chronic liver disease, non-transfemoral approach and postoperative complications. The unbiased estimate of the C-index was 0.81 and the model had excellent calibration. Conclusions One out of every four patients undergoing TAVR is discharged to a location other than home. Identification of preoperative factors associated with non-home discharge can assist patient counseling and postoperative disposition planning. | Alexis K Okoh Ebru Ozturk Justin Gold Emaad Siddiqui Nehal Dhaduk Bruce Haik Chun-Guang CHEN Marc Cohen Mark J Russo | 2020 | Journal of Geriatric Cardiology2020，17，10： | 1 |
| 16 | Psychiatric disorders in systemic lupus erythematosus 显示文摘 | Hutchinson GA Nehall JE Simeon UT | 1996 | West Indian Med J1996，45，2： | 1 |
| 17 | Cytokine profiles in patients receiving antioxidant therapy within the ANTICIPATE trial显示文摘AIM: To measure a broad profile of pro-and anti-inflammatory cytokines in patients with clinically proven chronic pancreatitis (CP) taking either antioxidant therapy or placebo as part of the larger ANTICIPATE study. METHODS: Patients with chronic pancreatitis were recruited to the ANTICIPATE study following informed consent and were randomised to intervention with either antox version 1.2-based antioxidant therapy or placebo. After a separate ethics committee amendment a subgroup of 7 patients from either arm of the study were selected for additional analysis of cytokines. Cytokines were measured at baseline and after 6 mo of either antox therapy or placebo by biochip array and enzyme-linked immunosorbent assay. RESULTS: Antioxidant therapy and placebo groups were well-matched in terms of age, gender, aetiology of CP, opiate use and disease duration. Baseline antioxidant levels were similar in patients allocated to the antioxidant group as compared to the group al- located to placebo. After 6 mo of antioxidant therapythere was significant elevation in vitamin C levels in the intervention group: 17.6 μg/mL (12.8-29.3 μg/mL) compared to 4.8 μg/mL (1.6-9.1 μg/mL) in placebo (P < 0.001; 95%CI: 9.0-20.2) with similar trends in selenium levels. There was no elevation in a broad array of pro-and anti-inflammatory cytokines in the antioxidant group compared to placebo [interleukin (IL)-1B, IL-4, IL-6, IL-10, tumor necrosis factor-α] either at baseline or after 6 mo of antioxidant therapy. CONCLUSION: Cytokine levels were low at baseline and at 6 mo despite a significant elevation in plasma antioxidants. In patients with CP, with opiate-dependent abdominal pain, circulating cytokine levels are low suggesting that pain in this disease is not simply a manifestation of inflammation. | Nehal Shah Ajith K Siriwardena | 2013 | World Journal of Gastroenterology2013，19，25： | 1 |
| 18 | Modulation of cardiometabolic pathways in skin and serumfrom patients with psoriasis 显示文摘 | Nehal N Mehta katherine Li Philippe Szapary | 2013 | J Transl Med2013，11，1： | 1 |
| 19 | Stability and rheology of heavy crude oil-in-water emulsion stabilized by an anionic- nonionic surfaetant mixture显示文摘 | NEHAL S AHMED | 1999 | Petroleum Science and Technology1999，17，56： | 1 |
| 20 | Erythromelalgia precipita-ted by acral erythema in the setting of thrombocytopenia显示文摘 | Coppa LM Nehal KS Young JW | 2003 | JAmAcadDermatol2003，48，6： | 1 |
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