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| 1 | Circulating tumor and cancer stem cells in hepatitis C virusassociated liver disease显示文摘AIM:To assess the role of circulating tumor cells(CTCs)and cancer stem cells(CSCs)in hepatitis C virus(HCV)-associated liver disease.METHODS:Blood and/or tissue samples were obtained from HCV(genotype 4)-associated hepatocellularcarcinoma patients(HCC;n=120),chronic hepatitis C patients(CH;n=30)and 33 normal control subjects(n=33).Serum levels of alpha-fetoprotein(AFP),alkaline phosphatase,and alanine and aspartate aminotransferases were measured.Cytokeratin 19(CK19)monoclonal antibody was used to enumerate CTCs,and CD133 and CD90 were used to enumerate CSCs by flow cytometry.The expression levels of the CSCs markers(CD133 and CD90)as well as telomerase,melanoma antigen encoding gene 1(MAGE1)and MAGE3 were assessed by RTPCR and quantitative real-time polymerase chain reactions.The number of CTCs and/or the expression levels of CK19,CD133,telomerase,MAGE1 and MAGE3 were correlated to the standard clinicopathologic prognostic factors and disease progression.RESULTS:Levels of AFP,alkaline phosphatase and aspartate aminotransferase were significantly different among the HCC,CH and control groups(P<0.001),whereas alanine aminotransferase differed significantly between patient(HCC and CH)and control groups(P<0.001).At the specified cutoff values determine by flow cytometry,CK19(49.8),CD90(400)and CD133(73)were significantly higher in the blood of HCC patients compared to those in the CH and control groups(P<0.001).On the other hand,CD133 at a 69.5 cutoff was significantly higher in the CH compared to the control group(P≤0.001).Telomerase,MAGE1 and MAGE3RNA were expressed in 55.71%,60.00%and 62.86%of the HCC patients,respectively,but were not detected in patients in the CH or control groups,which were statistically significant(Ps<0.001).The expression levels of telomerase,CD90,MAGE3,CD133 and CK19 were all significantly associated with high tumor grade and advanced stage in HCC patients(all P s<0.05).CONCLUSION:CTC counts and AFP,CK19,telomerase,and MAGE1/MAGE3 expression predict disease progression in patients with HCV,whereas telomerase,MAGE3,CD90,CD133 and CK19 are prognostic mark- | Abeer A Bahnassy Abdel-Rahman N Zekri Ahmed El-Bastawisy Amal Fawzy Marwa Shetta Nehal Hussein Dalia Omran Abdallah A S Ahmed Samir S El-Labbody | 2014 | World Journal of Gastroenterology2014，20，48： | 9 |
| 2 | Formation of fluid heavy oil-in-water emulsions for pipeline transportationt显示文摘 | Nehal S A Amal M N Nael N Z | 1999 | Fuel1999，78，59： | 1 |
| 3 | Alterations of the CD4 + , CD8 + , T cell subsets, interleukins -6, IL - 10, IL - 17,tumor necrosis factor-eL and soluble intercellular ad- he sion molecule-1 in rheumatoid arthritis and osteoarthri- tis :preliminary observations 显示文摘 | Mahmoud R Nehal A Fathi B | 2008 | Pathol Oncol Res2008，14，3： | 1 |
| 4 | AIterations of the CD4+,CD8+T cell subsets,interleukins-16,IL-10,IL-17,tumor necrosis factor-αand soluble intercellular adhe sion molecule-1in rheumatoid arthritis and osteoarthritis:preliminary observations显示文摘 | Mahmoud R Nehal A Fathi B et a1 | 2008 | Pathol Oncol Res2008，14，3： | 1 |
| 5 | Effects of topical tretinoin on photodamaged skin:a histologic study显示文摘 | Gonzalez-Serva A Nehal K | 1991 | Arch Dermatol1991，127，： | 1 |
| 6 | Psychiatrie disorders in Systemic Lu-pus Erythematosus显示文摘 | HUTCHINSON G A NEHALL J E SIMEON D T | 1996 | West Indian Med J1996，45，2： | 1 |
| 7 | Formation of Fluid Heavy oil-in-water Emnlsions for Pipeline Transportatioin显示文摘 | Nehal S A Amal M N Nael N Z | 1999 | Fuel1999，78，5： | 1 |
| 8 | Alterations of the CD4, CD8 T cell subsets, interleukins-llS, IL-10, IL-17, tumor necrosis factor-or and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations显示文摘 | Mahmoud R H Nehal A F Azza M E | 2008 | Pathol Oncol Res2008，14，3： | 1 |
| 9 | Formation of Fluid Heavy oil - in - water Emulsions for Pipeline Transportation 显示文摘 | Nehal S A Amal M N Nael N Z | 1999 | Fuel1999，78，5： | 1 |
| 10 | Alterations of the CD4+,CD8+ T cell subsets,interleukins-1β,IL-10,IL-17,tumor necrosis factor-α and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis:preliminary observations显示文摘 | Mahmoud R Nehal A Fathi B | 2008 | Pathol Oncol Res2008，14，3： | 1 |
| 11 | Water based demulsifier formulation and process for its use in dewatering and desalting crude hydrocarbon oils显示文摘 | Nehals A H Abend S Kilpatrick P K | 1999 | Petroleum Science and Technology1999，17，56： | 1 |
| 12 | Colloidal and rheological characterization of SWCNT in biological media显示文摘Wereport on the colloidal and rheological characterization of suspensions of commercial single-walled carbon nanotubes(SWCNT)and oxidized single walled carbon nanotubes(SWCNT-oxi24h),in water and fetal bovine serum(FBS).The effects of two surfactants,dodecyl-benzene sodium sulfonate(SBDS)and sodium dodecyl sulfate(SDS)at different concentrations(0.5-2.0%)on the zeta potential and the rheology of the suspensions is also investigated.SWCNT suspensions were characterized by Transmission Electron Microscopy(TEM)and Atomic Force Microscopy(AFM).The colloidal stability was determined by measurements of zeta potential in the physiological pH range 6.0 | Arisbel Cerpa Isabel Lado Oriella Quiroga Rodrigo Moreno Rosario García Sebastián Cerdán Nehal I.Abu-Lail | 2019 | International Journal of Smart and Nano Materials2019，10，4： | 0 |
| 13 | Cardiac stem cells: Current knowledge and future prospects显示文摘Regenerative medicine is the field concerned with the repair and restoration of the integrity of damaged human tissues as well as whole organs.Since the inception of the field several decades ago,regenerative medicine therapies,namely stem cells,have received significant attention in preclinical studies and clinical trials.Apart from their known potential for differentiation into the various body cells,stem cells enhance the organ's intrinsic regenerative capacity by altering its environment,whether by exogenous injection or introducing their products that modulate endogenous stem cell function and fate for the sake of regeneration.Recently,research in cardiology has highlighted the evidence for the existence of cardiac stem and progenitor cells(CSCs/CPCs).The global burden of cardiovascular diseases’morbidity and mortality has demanded an in-depth understanding of the biology of CSCs/CPCs aiming at improving the outcome for an innovative therapeutic strategy.This review will discuss the nature of each of the CSCs/CPCs,their environment,their interplay with other cells,and their metabolism.In addition,important issues are tackled concerning the potency of CSCs/CPCs in relation to their secretome for mediating the ability to influence other cells.Moreover,the review will throw the light on the clinical trials and the preclinical studies using CSCs/CPCs and combined therapy for cardiac regeneration.Finally,the novel role of nanotechnology in cardiac regeneration will be explored. | Radwa A Mehanna Marwa M Essawy Mona A Barkat Ashraf K Awaad Eman H Thabet Heba A Hamed Hagar Elkafrawy Nehal A Khalil Abeer Sallam Marwa A Kholief Samar S Ibrahim Ghada M Mourad | 2022 | World Journal of Stem Cells2022，14，1： | 0 |
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