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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | 狂犬病病毒单质粒拯救系统的建立及应用显示文摘旨在建立一种针对狂犬病病毒SAD L16株单质粒拯救的反向遗传操作系统。根据全长cDNA感染性克隆pSAD-L16 N、P和L基因上游序列的不同,分别设计多对引物将EMCVIRES序列、PV IRES序列和TaV 2A序列分别克隆入pSAD-L16载体的相应位置中,构建成5个重组狂犬病病毒全长cDNA克隆。在无需辅助质粒的情况下直接转染BSR T7/5细胞拯救病毒,并对拯救病毒进行生物学特性的鉴定和分析。结果表明,只有pSADNeNePeL和pSAD-NeNtPeL能够成功拯救出重组狂犬病病毒,获救病毒均高度致弱且增殖缓慢。获救的2株重组狂犬病病毒具有不同的遗传稳定性,表现出与野生型亲本毒株较大的差异。本研究首次建立起一种针对狂犬病病毒的单质粒拯救系统,为深入研究狂犬病病毒基因组结构与功能、分子致病机制以及狂犬病病毒与宿主相互作用等提供了一个基础的技术平台。 | 孙玉章 何彪 许运斌 丛彦龙 Karl-Klaus Conzelmann | 2015 | 畜牧兽医学报2015，46，11： | 2 |
| 3 | The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8显示文摘 | Sophie Clément Stéphanie Pascarella Stéphanie Conzelmann Carmen Gonelle-Gispert Kévin Guilloux Francesco Negro | 2010 | Journal of Hepatology2010，，5： | 2 |
| 4 | Significantly improved rescue of rabies virus from c DNA plasmids显示文摘 | Ghanem A Kern A Conzelmann KK | 2012 | Eur J Cell Biol2012，91，1： | 1 |
| 5 | Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group显示文摘 | Conzelmann K K Visser N Van Woensel P | 1993 | Virology1993，193，： | 1 |
| 6 | Matrix protein of rabies virus is responsible for the assembly and budding of bullet-shaped particles and interacts with the transmembrane spike glycoprotein G 显示文摘 | Mebatsion T Weiland F Conzelmann K K | 1999 | J Virol1999，73，： | 1 |
| 7 | Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice显示文摘 | Conzelmann LO Hines IN Kremer M | 2007 | Exp Biol Med(maywood)2007，232，4： | 1 |
| 8 | Nuclear hydrogen: An assessment of product flexibility and market viability显示文摘 | Botterud A Yildiz B Conzelmann G | 2008 | Energy Policy2008，36，： | 1 |
| 9 | Infectious rabies virus from cloned cDNA显示文摘 | Schnell MJ Mebatsion T Conzelmann KK | 1994 | EMBO1994，13，18： | 1 |
| 10 | Moleculer characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group 显示文摘 | Conzelmann K K Visser N Van Woensel P | 1993 | Virol1993，193，： | 1 |
| 11 | Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3 显示文摘 | Bossert B Marozin S Conzelmann K K | 2003 | J Virol2003，77，： | 1 |
| 12 | Development of two real-time PCR assays for the detection of Mycoplasma hyopneumoniae in clinical samples 显示文摘 | Dubosson C R Conzelmann C Miserez R | 2004 | Vet Microbiol2004，102，12： | 1 |
| 13 | Inhibition of Toll-like receptor 7- and 9- mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus 显示文摘 | Schlender J Hornung V Finke S Gfinthner-Biller M Marozin S Brz6zka K Moghim S Endres S Hartmann G Conzelmann KK | 2005 | J Virol2005，79，9： | 1 |
| 14 | Mor-tality in patients with acute aortic dissection type A : anal-ysis of pre-and intraoperative risk factors from theGermanRegistry for Acute Aortic Dissection Type A ( GEKAA-DA) 显示文摘 | Conzelmann L 0 Weigang E Mehlhom U | 2016 | Eur J Cardiothorac Surg2016，49，2： | 1 |
| 15 | Is fall prevention by vitamin D mediated by a change in postural or dy- namic balance? 显示文摘 | Bischoff - Ferrari HA Conzelmann M Stahelin HB | 2006 | Osteoporos Int2006，17，5： | 1 |
| 16 | Neuronal expression of foreign genes with recombinant rabies virus variants显示文摘 | Etessami R Conzelmann KK Marion R al et | 2000 | Rev Neurol (Paris)2000，156，3： | 1 |
| 17 | Molecular characterization of porcine reproductive and respiratory syndrome virus,a member of the arterivirus group显示文摘 | Conzelmann K K Visser N Van Woensel P | 1993 | Virology1993，193，1： | 1 |
| 18 | Molecular characterization of porcine reproductive and respiratory syndrome virus,a member of the arterivirus group显示文摘 | Conzelmann K K Visser N Van W P | 1993 | Virology1993，193，： | 1 |
| 19 | Molecular characterization of porcine reproductive and respiratory syndrome virus,a member of the Arterivirus group显示文摘 | Conzelmann K K Visser N Van Woensel P | | 0，，： | 1 |
| 20 | Nonsegmentad negative-strand RNA viruses:Genetics and manipulation of viral genomes显示文摘 | Conzelmann K K | 1998 | Annual Review of Genetics1998，32，1： | 1 |
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