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| 1 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 2 | Cannabidiol does not display drug abuse potential in mice behavior显示文摘Recent evidence suggests that cannabidiol(CBD)may be useful for the treatment of different neuropsychiatric disorders.However,some controversy regarding its profile as a drug of abuse hampers the further development of basic and clinical studies.In this study,the behavioral profile of CBD as a potential drug of abuse was evaluated in C57BL/6J mice.Reinforcing properties of CBD(15,30,and 60 mg/kg;i.p.)were assessed using the conditioned place preference(CPP)paradigm.Spontaneous withdrawal symptoms and motor activity in the open field were examined 12 h after the last CBD administration(30 mg/kg/12 h,i.p.,6 days).CBD plasma concentrations were measured at 2,4,8,12,and 24 h after the administration of CBD(30 mg/kg,i.p.).Furthermore,an oral CBD selfadministration paradigm(50 mg/kg;CBD water-soluble 1.2 mg/mL)was performed to evaluate whether this drug produced any effects on motivation compared with a non-reinforcing substance(water).We found that CBD failed to induce CPP,withdrawal symptoms,or altered motor behavior 12 h after its administration.At that time,only traces of CBD were detected,ensuring that the lack of alterations in somatic signs and locomotor activity was not due to residual drug in plasma.Interestingly,mice displayed similar motivation and consumption of CBD and water.Taken together,these results show that CBD lacks activity as a drug of abuse and should stimulate the development of the basic and clinical studies needed to elucidate its potential therapeutic use for the treatment of neuropsychiatric and drug use disorders. | Adrián Viudez-Martínez María S.García-Gutiérrez Juan Medrano-Relinque Carmen M.Navarrón Francisco Navarrete Jorge Manzanares | 2019 | Acta Pharmacologica Sinica2019，40，3： | 2 |
| 3 | A New Ranking Method Based on Relative Position Estimate and Its Extensions显示文摘 | Fukushima M Mine H | 1979 | IEEE Transactions on Systems Man and Cybernetics1979，，9： | 1 |
| 4 | Influence of osmotic pre-treatment and microwave application on properties of air dried strawberry related to structural changes显示文摘 | Contreras C Esparza M E Navarrete N | 2007 | Europe Food Research Technology2007，224，： | 1 |
| 5 | Potential biomarkers of ageing显示文摘 | Simm A Nass N Bartling B Hofmann B Silber RE Navarrete Santos A | 2008 | Biol Chem2008，389，3： | 1 |
| 6 | Acute respiratory distress syndrome among trauma patients:trends in ICU mortality,risk factors,complications and resource utilization 显示文摘 | Navarrete NP Rodriguez A Reynolds N | 2001 | Intensive Care Med2001，27，7： | 1 |
| 7 | Iron deficiency and iron fortified foods - a review 显示文摘 | Martinez - Navarrete N Camacho M M Martinez - Lahuerta J at el | 2002 | Food Research International2002，35，： | 1 |
| 8 | Six-year mortality and quality of life in critically ill patients with chronic obstructive pulmonary disease显示文摘 | Rivera F R Navarrete N P Fernandez M E | 2006 | Crit Care Med2006，34，9： | 1 |
| 9 | Incidental differentiated thyroid carcinoma is less prevalent in Graves’ disease than in multinodular goiter显示文摘 | Eider Pascual Corrales Rosa Maria Príncipe Sara Laguna Muro Fernando Martínez Regueira Juan Manuel Alcalde Navarrete Francisco Guillén Grima Juan Carlos Galofré | 2012 | Endocrinología y nutrición (English Edition)2012，，3： | 1 |
| 10 | Advanced glycation end products, diabetes and ageing 显示文摘 | Nass N Bartling B Navarrete Santos A | 2007 | Z Gerontol Geriat2007，40，5： | 1 |
| 11 | Digestive enzymes present in crustacean feces as a tool for biochemical,physiological,and ecological studies显示文摘 | Córdova-Murueta J García-Carre(n)o F Navarrete del T | 2003 | Journal of experimental marine biology and ecology2003，297，： | 1 |
| 12 | Simazine Fenton's oxidation in a continuos reactor显示文摘 | RIVAS F J NAVARRETE V BELTRáN F J | 2004 | Appl Catal B2004，48，4： | 1 |
| 13 | Dependence of Boehmite Thermal Evolution on Its Atom Bond Lengths and Crystallite Size显示文摘 | X. Bokhimi J.A. Toledo-Antonio M.L. Guzmán-Castillo B. Mar-Mar F. Hernández-Beltrán J. Navarrete | 2001 | Journal of Solid State Chemistry2001，，2： | 1 |
| 14 | Patterns of recurrence and survival in breast cancer显示文摘 | Navarrete Montalvo D Gonzlez M N Montalvo V M T | 2008 | Oncol- Rep2008，20，3： | 1 |
| 15 | The social production of space in tourism enclaves: mayan children's perceptions of tourism boundaries 显示文摘 | Buzinde C N Manuel Navarrete D | 2013 | Annals of Tourism Research2013，43，： | 1 |
| 16 | Identification of influenza,parainfluenza, adenovirus and respiratory syncytial virus during rhinopharyngitis in a group of Mexican children with asthma and wheezing显示文摘 | Lopez PG Morfin Maciel BM Navarrete N | 2009 | Rev Alerg Mex2009，56，3： | 1 |
| 17 | Deep brain stimulation of the centromedian thalamic nucleus for the treatment of generalized and frontal epilepsies 显示文摘 | Valent~n A Garcia Navarrete E Chelvarajah R | 2013 | Epilepsia2013，54，： | 1 |
| 18 | Effect of apical size and taper on volume of irrigant delivered at working length with apical negative pressure at different root curvatures 显示文摘 | Gregorio C Arias A Navarrete N | 2013 | J Endod2013，39，1： | 1 |
| 19 | Advanced glycation end products,diabetes and ageing显示文摘 | Nass N Bartling B Navarrets Santos A | 2007 | Z Gerontol Geriatr2007，40，5： | 1 |
| 20 | A new ranking method based oil relative position estimate and its extensions显示文摘 | Navarrete Jr N Fukushinla M Mine H | 1979 | IEEE Transactions on Systems Man and Cybernetics1979，，： | 1 |
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