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| 1 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 2 | Cannabidiol does not display drug abuse potential in mice behavior显示文摘Recent evidence suggests that cannabidiol(CBD)may be useful for the treatment of different neuropsychiatric disorders.However,some controversy regarding its profile as a drug of abuse hampers the further development of basic and clinical studies.In this study,the behavioral profile of CBD as a potential drug of abuse was evaluated in C57BL/6J mice.Reinforcing properties of CBD(15,30,and 60 mg/kg;i.p.)were assessed using the conditioned place preference(CPP)paradigm.Spontaneous withdrawal symptoms and motor activity in the open field were examined 12 h after the last CBD administration(30 mg/kg/12 h,i.p.,6 days).CBD plasma concentrations were measured at 2,4,8,12,and 24 h after the administration of CBD(30 mg/kg,i.p.).Furthermore,an oral CBD selfadministration paradigm(50 mg/kg;CBD water-soluble 1.2 mg/mL)was performed to evaluate whether this drug produced any effects on motivation compared with a non-reinforcing substance(water).We found that CBD failed to induce CPP,withdrawal symptoms,or altered motor behavior 12 h after its administration.At that time,only traces of CBD were detected,ensuring that the lack of alterations in somatic signs and locomotor activity was not due to residual drug in plasma.Interestingly,mice displayed similar motivation and consumption of CBD and water.Taken together,these results show that CBD lacks activity as a drug of abuse and should stimulate the development of the basic and clinical studies needed to elucidate its potential therapeutic use for the treatment of neuropsychiatric and drug use disorders. | Adrián Viudez-Martínez María S.García-Gutiérrez Juan Medrano-Relinque Carmen M.Navarrón Francisco Navarrete Jorge Manzanares | 2019 | Acta Pharmacologica Sinica2019，40，3： | 2 |
| 3 | Histopathological changes in sheep experimentally infected with Babesia ovis 显示文摘 | Habela M A Reina D Navarrete I | 1991 | Veterinary Parasitology1991，38，1： | 2 |
| 4 | Chemical state and distribution of Mn ions in the absence and the presence of fluxes显示文摘 | Navarrete E L Caballero A Gonzalez - Elipe A R | 2004 | Journal of the Europe Ceramic Society2004，，24： | 1 |
| 5 | Cloning and constitutive expression of Deschampsia antarctica Cu/Zn superoxide dismutase in Pichia pastoris显示文摘 | Sátnchez-Venegas J R Navarrete A Dinamarca J | | 0，，： | 1 |
| 6 | Digestive enzymes in juvenile green abalone,Haliotis fulgens, fed natural food显示文摘 | Garcia-Carrefio F L Navarrete del Toro M A Serviere-Zaragoza E | 2003 | Comp Biochem Physiol2003，134，： | 1 |
| 7 | Anthelmintic properties of α-anshool from Zanthoxylum libmannianum 显示文摘 | NAVARRETE A HONG E | 1996 | Planta Medica1996，62，3： | 1 |
| 8 | Fuzzy temporal constraint logic: A valid resolution principle显示文摘 | CARDENAS VIEDMA M A MARIN MORALES R NAVARRETE SANCHEZ I | 2001 | Fuzzy Sets and Systems2001，17，： | 1 |
| 9 | Structural insight into epothilones antitumor activity based on the con{ormational pret- erences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations 显示文摘 | Jimenez V A Alderete J B Navarrete K R | 2015 | J Biomol Struct Dyn2015，33，4： | 1 |
| 10 | Wood panel adhesives from low molecular mass lignin and tannin without syn- thetic resins 显示文摘 | Navarrete P Mansouri H R Pizzi A | 2010 | Journal of Adhesion Science and Technology2010，24，810： | 1 |
| 11 | Gastroprotective effect of Astragaloside Ⅳ:role of prostaglandins,sulthydryls and nitric oxide显示文摘 | Navarrete A Arrieta J Terrones L | 2005 | J Pharm Pharmacol2005，57，8： | 1 |
| 12 | Combined phospholipid biomarker-16S rRNA gene denaturing gradient gel electrophoresis analysis of bacterial diversity and physiological status in an intertidal microbial mat显示文摘 | Villanueva L Navarrete A Urmeneta J | 2004 | Applied and Environmental Microbiology2004，70，11： | 1 |
| 13 | Ontogenetic variation in digestive proteinase activity of larvae and postlarvae of the pink shrimp FaoCantepenaeus paulensis ( Crustacea: Decapoda: Penaeidae) 显示文摘 | Lemos D Hernandez-Cortes M P Navarrete A | 1999 | Marine Biol1999，135，： | 1 |
| 14 | Gastroprotective effect of Astragaloside IV : role of prostaglandins, sulthydryls and nitric oxide 显示文摘 | Navarrete A Arrieta J Terrones L | 2005 | J Pharm Pharmaco2005，57，8： | 1 |
| 15 | Potential biomarkers of ageing显示文摘 | Simm A Nass N Bartling B Hofmann B Silber RE Navarrete Santos A | 2008 | Biol Chem2008，389，3： | 1 |
| 16 | Pathogenesis: HLA--DQ7 antigen andresistance to variant CJD 显示文摘 | J alkson GS Beck J A Navarrete | 2001 | Nature2001，414，15： | 1 |
| 17 | Acute respiratory distress syndrome among trauma patients:trends in ICU mortality,risk factors,complications and resource utilization 显示文摘 | Navarrete NP Rodriguez A Reynolds N | 2001 | Intensive Care Med2001，27，7： | 1 |
| 18 | Ontogenetic variation in digestive protease activity of larvae and postlarva of the pink shrimp Farfantepenaeus paulensis显示文摘 | Lemos D Hernandez-Cortes M P Navarrete A | 1999 | Mar Biol1999，135，： | 1 |
| 19 | Ten case of ciguatera fish poisoning in Yucatanl显示文摘 | Arcila Herrera H Castello Navarrete A Mendoza Ayora J | 1998 | Rev Invest Clin1998，50，2： | 1 |
| 20 | Treatment of common bile duct injuries during laparoscopic cholecystectomy;endoscopic and surgical management显示文摘 | Csendes A Navarrete C Burdiles P | 2001 | World J Surg2001，25，： | 1 |
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