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| 1 | MicroRNA-21 in the pathogenesis of acute kidney injury显示文摘Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or death.Therefore,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat AKI.However,the mech-anisms modulating the pathogenesis of AKI still remain largely undetermined.MicroRNAs(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expres-sion.MicroRNA-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in AKI.As a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing AKI.This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI. | Ya-Feng Li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan Liu Lihua Wang Rongshan Li | 2013 | Protein & Cell2013，4，11： | 18 |
| 2 | Subclinical atherosclerosis in northern and southern China: the Chinese paradox显示文摘背景冠的心疾病(CHD ) 的发生是更高的在北比在南部的中国,然而,在传统的 CHD 的差别冒险的,解释这。没有学习在可以帮助在发生解释差别的无临床症状的动脉粥样硬化检验了差别。这研究为在北、南部的中国之间的石灰化用冠的计算断层摄影术(CT ) 在无临床症状的动脉粥样硬化检验了这些差别。我们在一个大多中心选择了参加者的一件随机的样品的方法为冠的钙在一个北城市(诺思) 里扫描的进行中的流行病的学习(北京, n = 49 ) 并且在二个南部的城市(南方) 里(上海, n = 50,并且广州, n = 50 ) 。从三个领域中心的参加者(意味着年龄 67 年) 经历了用动脉粥样硬化扫描的多种族的学习为冠的钙测量扫描的冠的风险因素评估和心脏的 CT 协议。结果调整了在诺思中国(北京) 的转变木头的冠的动脉钙 20 是 3.1 +/-0.4 并且在华南(上海和广州) 是 2.2 +/- 0.3 (P = 0.04 ) 。为北京的北城市的吝啬的钙分数比广州的南部的城市的高三倍(P = 0.01 ) 并且比为上海的南部的城市高 2.5 倍(P = 0.03 ) 。结论无临床症状的动脉粥样硬化的程度在广州和上海的二个南部的城市里比那在北京的北城市里是显著地更高的,甚至在为标准心脏的风险因素调整以后。这发现建议标准风险因素充分不在临床的 CHD 发生解释北方南方差别。 | Jie Huang Yang-Feng Wu Xiao-Qing Liu Ding Ding Lian-Cheng Zhao Bin Lu Xian Li Nathan D Wong Laurie D Dustin Stanley P Azen Robert C Detrano | 2011 | Journal of Geriatric Cardiology2011，8，2： | 7 |
| 3 | Stem cells:An eventual treatment option for heart diseases显示文摘Stem cells are of global excitement for various diseases including heart diseases. It is worth to understand the mechanism or role of stem cells in the treatment of heart failure. Bone marrow derived stem cells are commonly practiced with an aim to improve the function of the heart. The majority of studies have been conducted with acute myocardial infarction and a few has been investigated with the use of stem cells for treating chronic or dilated cardiomyopathy. Heterogeneity in the treated group using stem cells has greatly emerged. Ever increasing demand for any alternative made is of at most priority for cardiomyopathy. Stem cells are of top priority with the current impact that has generated among physicians. However,meticulous selection of proper source is required since redundancy is clearly evident with the present survey. This review focuses on the methods adopted using stem cells for heart diseases and outcomes that are generated so far with an idea to determine the best therapeutic possibility in order to fulfill the present demand. | Joseph C Bilgimol Subbareddy Ragupathi Lakshmanan Vengadassalapathy Nathan S Senthil Kali-muthu Selvakumar M Ganesan Sadananda Rao Manjunath | 2015 | World Journal of Stem Cells2015，7，8： | 6 |
| 4 | 出口雷诺数对平面射流自保持性的影响显示文摘通过实验研究出口雷诺数对平面湍流射流自保持性的影响.测量的射流来自相同的喷嘴但不同的雷诺数Re(≡Ujh/ν,其中Uj是出口平均速度、h是窄缝出口的厚度和ν是黏性系数),其变化范围是Re=4582—57735.所得的数据包括沿轴线的平均速度、湍流强度、积分尺度、高阶矩和能谱.实验发现,随着Re的增大,平面射流发展减慢,平均速度和湍流强度更难达到自保持状态.沿轴线的积分尺度随轴向距离成线性增长但随雷诺数的增大增长速度减慢.同时发现,平面射流的局部雷诺数会随轴向距离的增大而增大.最后,通过对比湍流能谱并结合以往发表的结果,对不同雷诺数的射流所表现出的不同的统计学行为给出了解释. | 米建春 冯宝平 Deo Ravinesh C Nathan Graham J | 2009 | 物理学报2009，58，11： | 3 |
| 5 | 临床实践指南应当包含治疗负担显示文摘医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传统指南的建议也是从同样角度提出的。最近的指南会考虑患者的价值观以及指南建议行为的可接受性和可行性,但对治疗负担没有明确规定。这使患者很难根据自己的价值观和能力对治疗做出明智的决定。 | Claudia C Dobler Nathan Harb Catherine A Maguire Carol L Armour Courtney Coleman M Hassan Murad 邓璇(译) 莫云凌(校) | 2019 | 英国医学杂志中文版2019，22，3： | 3 |
| 6 | Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation显示文摘B″蛋白质磷酸酶 2A (PP2A ) 的 /PR72 家庭一个重要 PP2A 家庭涉及多样的细胞的过程,并且特别地由钙绑定调整了到规章的子单元。在这个家庭的 PR70 子单元与房间部门控制 6 交往(Cdc6 ) ,为 DNA 复制的控制重要的一个房间周期管理者。这里,我们在 2.1 和 2.4 Å 的一个决定报导孤立的 PR72 和 trimeric PR70 holoenzyme 的水晶结构;,分别地并且在 Cdc6 dephosphorylation 的 vitro 描述。holoenzyme 结构表明 PR70 钙绑定主题之一直接联系支架子单元,导致在所有 PP2A holoenzymes 之中的最紧缩的支架子单元符合构造。PR70 也在活跃地点附近区别地绑在催化子单元,它被要求让 PR70 向 Cdc6 提高磷酸酶活动。我们的研究为 B″ 的唯一的规定提供一个结构的基础;由钙离子的 /PR72 holoenzymes,并且在 PP2A holoenzymes 之中为底层特性的精确控制建议机制。 | Nathan Wlodarchak Feng Guo Kenneth A Satyshur Li Jiang Philip D Jeffrey Tingwan Sun Vitali Stanevich Marc C Mumby Yongna Xing | 2013 | Cell Research2013，23，7： | 3 |
| 7 | Reducing Nitrogen Loss during Poultry Litter Composting Using Biochar显示文摘 | Steiner Christoph Das K C Melear Nathan Lakly Donald | 2010 | Journal of Environmental Quality2010，，4： | 2 |
| 8 | Specificity of a third kind:reactive oxygen and nitrogen intermediates in cell signaling显示文摘 | | 2003 | J Clin Invest2003，111，： | 1 |
| 9 | Neutrophils and immunity: challenges and opportunities 显示文摘 | Nathan C | 2009 | Nat Rev Immunol2009，6，： | 1 |
| 10 | Nonresolving inflammation显示文摘 | Nathan C Ding A | 2010 | Cell2010，140，6： | 1 |
| 11 | The effect of different initial conditions on the exit flow from a fluidic precessing jet nozzle显示文摘 | Wong C Y Nathan G J O' Doherty T | 2003 | Experiments in Fluids2003，36，： | 1 |
| 12 | Nitric oxide as a secretory product of mammalian cells显示文摘 | Nathan C | 1992 | FASEB J1992，6，12： | 1 |
| 13 | Points of control in inflammation 显示文摘 | NATHAN C | 2002 | Nature2002，420，6917： | 1 |
| 14 | Estradiol regulation of astro- glia and apolipoprotein E:an important role in neuronal regenera- tion显示文摘 | Struble RG Nathan BP Cady C | 2007 | Exp Geronto12007，42，12： | 1 |
| 15 | Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients显示文摘 | Nathan CA Amirghahri N Rice C | 2002 | Laryngoscope2002，112，12： | 1 |
| 16 | Nitric oxide synthases: roles, tolls, and controls显示文摘 | Nathan C Xie QW | 1994 | Cell1994，78，6： | 1 |
| 17 | Phase Ⅱ trial of 96-hour paclitaxel plus oral estramustine phosphate in metastatic hormone-refractory prostate cancer显示文摘 | Hudes G R Nathan F Khater C | 1997 | J Clin Oncol1997，15，： | 1 |
| 18 | sheddiNg of tumor necrosis factor receptors byactivated human neutrophils显示文摘 | Porteu F Nathan C | 1990 | J Exp Med1990，172，2： | 1 |
| 19 | Macrophage deactivation by interleukin 10显示文摘 | Bogdan C Vodovotz Y Nathan C | 1991 | The Journal of Experimental Medicine1991，174，6： | 1 |
| 20 | Nitric Oxide as a secretory product of mammalian cells显示文摘 | Nathan C | 1992 | FASEBJ1992，6，12： | 1 |
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