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| 1 | DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach显示文摘Approximately 80%-95%of gastrointestinal stromal tumors(GISTs)show positive staining for KIT,while the other 5%-20%show negative staining.If the tumor is negative for KIT,but is positive for CD34,a histological diagnosis is possible.However,if the tumor is negative for KIT,CD34,S-100,and SMA,a definitive diagnosis is often challenging.Recently,Discovered on GIST-1(DOG1)has received considerable attention as a useful molecule for the diagnosis of GIST.DOG1,a membrane channel protein,is known to be overexpressed in GIST.Because the sensitivity and specificity of DOG1 are higher than those of KIT,positive staining for DOG1has been reported,even in KIT-negative GISTs.KITnegative GISTs most commonly arise in the stomach and are mainly characterized by epithelioid features histologically.We describe our experience with a rare case of a KIT-negative GIST of the stomach that was diagnosed by positive immunohistochemical staining for DOG1 in a patient who presented with severe anemia.Our findings suggest that immunohistochemical staining for DOG1,in addition to gene analysis,is useful for the diagnosis of KIT-negative tumors that are suspected to be GISTs. | Takuya Wada Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myunguchul Kim Wasaburo Koizumi Tetsuo Mikami | 2013 | World Journal of Gastroenterology2013，19，47： | 11 |
| 2 | Argon plasma coagulation for superficial esophageal squamous-cell carcinoma in high-risk patients显示文摘AIM: To evaluate the usefulness and safety of argon plasma coagulation (APC) for superficial esophageal squamous-cell carcinoma (SESC) in high-risk patients. METHODS: We studied 17 patients (15 men and 2 women, 21 lesions) with SESC in whom endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and open surgery were contraindicated from March 1999 through February 2009. None of the patients could tolerate prolonged EMR/ESD or open surgery because of severe concomitant disease (e.g., liver cirrhosis, cerebral infarction, or ischemic heart disease) or scar formation after EMR/ESD and chemoradiotherapy. After conventional endoscopy, an iodine stain was sprayed on the esophageal mucosa to determine the lesion margins. The lesion was then ablated by APC. We retrospectively studied the treatment time, number of APC sessions per site, complications, presence or absence of recurrence, and time to recurrence.RESULTS: The median duration of follow-up was 36 mo (range: 6-120 mo). All of the tumors were macroscopically classified as superficial and slightly depressed type (0-Ⅱc). The preoperative depth of invasion was clinical T1a (mucosal cancer) for 19 lesions and clinical T1b (submucosal cancer) for 2. The median treatment time was 15 min (range: 10-36 min). The median number of treatment sessions per site was 2 (range: 1-4). The median hospital stay was 14 d (range: 5-68 d). Among the 17 patients (21 lesions), 2 (9.5%) had recurrence and underwent additional APC with no subsequent evidence of recurrence. There were no treatment-related complications, such as bleeding or perforation. CONCLUSION: APC is considered to be safe and effective for the management of SESC that cannot be resected endoscopically because of underlying disease, as well as for the control of recurrence after EMR and local recurrence after chemoradiotherapy. | Kumiko Tahara Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Kento Nakatani Akira Naruke Myungchul Kim Wasaburo Koizumi | 2012 | World Journal of Gastroenterology2012，18，38： | 4 |
| 3 | Double-endoscope endoscopic submucosal dissection for the treatment of early gastric cancer accompanied by an ulcer scar (with video)显示文摘 | Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Kenji Ishido Akira Naruke Tetuo Mikami Wasaburo Koizumi | 2013 | Gastrointestinal Endoscopy2013，，2： | 3 |
| 4 | Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomized prospective phase II clinical trial显示文摘 | T. Sasaki S. Tanabe M. Azuma A. Sato A. Naruke K. Ishido C. Katada K. Higuchi W. Koizumi | 2012 | Endoscopy2012，，06： | 2 |
| 5 | Prognosis and survival in resected lung carcinoma based on the new international staging system 显示文摘 | Naruke T Goya T Tsuchiya R | 1988 | J Thorac Cardiovasc Surg1988，96，3： | 1 |
| 6 | Pleural lavage cytology immediately after thoracotomy as a prognosis factor for patients with lung cancer显示文摘 | Kondo H Naruke T Tsuchiya R | 1989 | J Cancer Res1989，80，： | 1 |
| 7 | What are the risk factors for arrhythmias after thoracic operations? A retrospective multivaviate analgsis of 267 consecutive thoracic operations显示文摘 | Asamura H Naruke T Tsuchiya R | 1993 | J Thorac Cardimiasc Surg1993，106，6： | 1 |
| 8 | Differentiating Between Atypical Adenomatous Hyperplasia and Bronchioloalveolar Carcinoma Using the Computed Tomography Number Histogram显示文摘 | Nomori H Ohtsuka T Naruke T | 2003 | Ann Thorac Surg2003，76，3： | 1 |
| 9 | Prognosis and survival in resected lung carcinoma based on the new international staging system显示文摘 | Naruke T Goya T Tsuchiya R | 1988 | J Thorac Cardiovasc Surg1988，96，： | 1 |
| 10 | What is the advantage of a thoracoscopic lobectomy over a limited thoracotomy procedure for lung cancer surgery 显示文摘 | Nomori H Horio H Naruke T | 2001 | Ann Thorac Surg2001，72，： | 1 |
| 11 | A novel organic/inorganic hybrid nanoporous material incorporating Keggin-type polyoxometalates显示文摘 | Lan Yang Haruo Naruke Toshihiro Yamase | 2003 | Inorganic Chemistry Communications2003，6，： | 1 |
| 12 | Implications of staging in lung cancer 显示文摘 | Naruke T Tsuchiya R Kondo H | 1997 | Chest1997，112，4： | 1 |
| 13 | Pleural lavage cytology immediately after thoracotomy as a prognostic factor for patients with lung cancer显示文摘 | Kondo H Naruke T Tsuchiya R | 1989 | Jpn J Cancer Res1989，80，3： | 1 |
| 14 | Surgical treatment for lung cancer with metastases to mediastinal lymph nodes 显示文摘 | Naruke T Suemasu K Ishikawa S | 1976 | J Thorac Cardiovasc Surg1976，71，2： | 1 |
| 15 | Lymph node mapping and curability at various levels of metastasis in resected lung cancer 显示文摘 | Naruke T Suemasu K Ishikawa S | 1978 | J Thorac CardiovascSurg1978，76，： | 1 |
| 16 | Structural evaluation of column-height controls at a toe-thrust discovery, deep-water Niger Delta显示文摘 | Kostenko O V Naruk S J Hack W et 81 | 2008 | AAPG Bulletin2008，92，12： | 1 |
| 17 | What are the risk factors for arrhythmias after thoracic operations? A retrospective multivariate analysis of 267 consecutive thoracic operations显示文摘 | Asamura H Naruke T Tsuchiva R | 1993 | Thorac Cardiovasc Surg1993，106，6： | 1 |
| 18 | Prognosis and survival in resected lung carcinoma based on the new international staging sysem显示文摘 | Naruke T Goya T Tsuchiya R | 1988 | J Thorac Cardiovasc Surg1988，96，： | 1 |
| 19 | Peripheral lung cancer: screening and detection with low-dose spiral CT vs radiography 显示文摘 | Kaneko M Eguchi K Ohmatsu H Kakinuma R Naruke T Suenasu K Moriyama N | 1996 | Radiology1996，201，3： | 1 |
| 20 | Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer显示文摘 | Hatanaka H Abe Y Naruke M | 2001 | Clin Cancer Res2001，7，5： | 1 |
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