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| 1 | Alcoholic disease: Liver and beyond显示文摘The harmful use of alcohol is a worldwide problem.It has been estimated that alcohol abuse represents the world’s third largest risk factor for disease and disability;it is a causal factor of 60 types of diseases and injuries and a concurrent cause of at least 200 others.Liver is the main organ responsible for metabolizing ethanol,thus it has been considered for long time the major victim of the harmful use of alcohol.Ethanol and its bioactive products,acetaldehyde-acetate,fatty acid ethanol esters,ethanol-protein adducts,have been regarded as hepatotoxins that directly and indirectly exert their toxic effect on the liver.A similar mechanism has been postulated for the alcohol-related pancreatic damage.Alcohol and its metabolites directly injure acinar cells and elicit stellate cells to produce and deposit extracellular matrix thus triggering the'necrosis-fibrosis'sequence that finally leads to atrophy and fibrosis,morphological hallmarks of alcoholic chronic pancreatitis.Even if less attention has been paid to the upper and lower gastrointestinal tract,ethanol produces harmful effects by inducing:(1)direct damaging of the mucosa of the esophagus and stomach;(2)modification of thesphincterial pressure and impairment of motility;and(3)alteration of gastric acid output.In the intestine,ethanol can damage the intestinal mucosa directly or indirectly by altering the resident microflora and impairing the mucosal immune system.Notably,disruption of the intestinal mucosal barrier of the small and large intestine contribute to liver damage.This review summarizes the most clinically relevant alcohol-related diseases of the digestive tract focusing on the pathogenic mechanisms by which ethanol damages liver,pancreas and gastrointestinal tract. | Alba Rocco Debora Compare Debora Angrisani Marco Sanduzzi Zamparelli Gerardo Nardone | 2014 | World Journal of Gastroenterology2014，20，40： | 27 |
| 2 | Spinal cord involvement in patients with cirrhosis显示文摘A severe spinal cord involvement may rarely occur in patients with cirrhosis and other chronic liver diseases;this complication is usually associated with overt liver failure and surgical or spontaneous porto-systemic shunt.Hepatic myelopathy(HM)is characterized by progressive weakness and spasticity of the lower extremities,while sensory and sphincter disturbances have rarely been described and are usually less important.The diagnosis is assigned in the appropriate clinical setting on clinical grounds after the exclusion of other clinical entities leading to spastic paraparesis.Magnetic resonance imaging is often unremarkable;however,also intracerebral corticospinal tract abnor-malities have been reported recently.The study of motor evoked potentials may disclose central conduction abnormalities even before HM is clinically manifest.HM responds poorly to blood ammonia-lowering and other conservative medical therapy.Liver transplantation represents a potentially definitive treatment for HM in patients with decompensated cirrhosis of Child-Pugh B and C grades.Other surgical treatment options in HM include surgical ligation,shunt reduction,or occlusion by interventional procedures. | Raffaele Nardone Yvonne Hller Monica Storti Piergiorgio Lochner Frediano Tezzon Stefan Golaszewski Francesco Brigo Eugen Trinka | 2014 | World Journal of Gastroenterology2014，20，10： | 12 |
| 3 | Cancer stem cell hypothesis and gastric carcinogenesis: Experimental evidence and unsolved questions显示文摘Traditionally, the clonal evolution model has been used to explain gastric cancer (GC) growth dynamics. According to this model, GC cells result from multiple mutations over time resulting in a population of continually diversifying cells. This heterogeneity enables the survival of different clones under particular conditions allowing growth at metastatic locations or resistance to chemotherapeutics. Cancer stem cell (CSC) theory completely overturns this traditional understanding of cancer suggesting that only CSCs can self-renew and promote tumor growth. CSCs are relatively refractory to conventional therapies, thus explaining why anti-cancer therapies are far from curative and why relapses of cancer are frequent. The identification of the CSC component of a tumor might, thus, open new therapeutic perspective based on the selective targeting of this small population of cells. In this review we examine the current scientific evidence supporting the existence of CSC in gastric tumors and analyze the main unsolved questions of this difficult field of cancer research. | Alba Rocco Debora Compare Gerardo Nardone | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 11 |
| 4 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 5 | Diet,H pylori infection and gastric cancer:Evidence and controversies显示文摘Despite decreasing incidence and mortality rates, gastric cancer (GC) still remains the fourth most common cancer and the second most common cause of cancer-related deaths worldwide. Due to the limited treatment options, at present, prevention is likely to be the only effective means of controlling this disease. The success of a prevention strategy depends upon the understanding of etiological and pathogenic mechanisms underlying gastric carcinogenesis. The etiology of GC is multi-factorial, however, in the recent years, mounting evidence suggests that environmental factors play a key role. The most important environmental factors implicated in the pathogenesis of GC are diet and H pylori infection. Thus, modifications in lifestyle and dietary habit associated with eradication of H pylori infection could hypothetically represent the most promising potential targets for GC prevention. In this review we will address the evidence and the controversies on the role of these agents in noncardia GC by focusing on retrospective and prospective observational studies and interventional trials. | Alba Rocco Gerardo Nardone | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 6 | 紫锥菊提取物Polinacea^(TM)对乳牛外周血单核细胞免疫功能的影响显示文摘采用ELISA方法检测了不同浓度的狭叶紫锥菊提取物PolinaceaTM在体外结合刀豆蛋白A(ConA,1μg/mL)和美洲商陆有丝分裂原(PWM,0.6μg/mL)刺激6头荷斯坦乳牛外周血单核细胞(PBMC)的增殖效果及PolinaceaTM结合ConA(2.27μg/mL)对γ-干扰素(IFN-γ)产量的影响。PolinaceaTM加入细胞培养基的浓度分别为0、6.3、20、60和180μg/mL。结果表明:PolinaceaTM最高浓度(180μg/mL)与最低浓度(6.3μg/mL)对PBMC的增殖分别高于对照组将近10倍与2倍;180μg/mL PolinaceaTM结合ConA对PBMC的增殖有显著的抑制作用;20、60μg/mL PolinaceaTM结合PWM可显著刺激PBMC的增殖;PolinaceaTM能诱导外周血淋巴细胞产生IFN-γ,但不同浓度的紫锥菊提取物对IFN-γ的产生无显著影响(P>0.05)。试验结果为体内试验提供了有力的理论依据。 | 吴华 NARDONE A LACETERA N | 2010 | 中国兽医科学2010，40，5： | 8 |
| 7 | Focus on acute diarrhoeal disease显示文摘Diarrhoea is an alteration of normal bowel movement characterized by an increase in the water content, volume, or frequency of stools. Diarrhoea needs to be classif ied according to the trends over time (acute or chronic) and to the characteristics of the stools (watery, fatty, inflammatory). Secretory diarrhoeas, mostly acute and of viral aetiology in more than 70% of cases, are by far the most important subtype of diarrhoeas in terms of frequency, incidence and mortality (over 2.5 million deaths/year in developing countries). Natural and synthetic opiates such as morphine, codeine, and loperamide which react with endogenous opiates (enkephalins, beta-endorphins, dynorphins) mainly act on intestinal motility and slow down transit. An antidiarrhoeal drug developed in recent years, racecadotril, acts as an enkephalinase inhibitor. Clinical studies have shown that it is just as effective as loperamide in resolving acute diarrhoea but with greater reduction in pain and abdominal distension. Some studies have explored the prevalence of diarrhoea in old age. An epidemiological study carried out in Italy by 133 General Practitioners on 5515 elderly outpatients reported a prevalence of diarrhoea, def ined according to the Rome criteria, of 9.1%. Infectious diseases (19%) and drug use (16%) were the most common causes of diarrhoea in old age. Regardless of the cause, the treatment of elderly patients with diarrhoea must include rehydration and nutritional support. Every year, more than 50 million tourists travel from industrialized countries to places where hygiene levels are poor. At least 75% of those travelling for short periods mention health problems, and in particular traveller's diarrhoea. | Fabio Baldi Maria Antonia Bianco Gerardo Nardone Alberto Pilotto Emanuela Zamparo | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 8 | Screening for and surveillance of gastric cancer显示文摘Although the prevalence of gastric cancer(GC) progressively decreased during the last decades,due to improved dietary habit,introduction of food refrigeration and recovered socio-economic level,it still accounts for 10% of the total cancer-related deaths. The best strategy to reduce the mortality for GC is to schedule appropriate screening and surveillance programs,that rises many relevant concerns taking into account its worldwide variability,natural history,diagnostic tools,therapeutic strategies,and cost-effectiveness. Intestinal-type,the most frequent GC histotype,develops through a multistep process triggered by Helicobacter pylori(H. pylori) and progressing from gastritis to atrophy,intestinal metaplasia(IM),and dysplasia. However,the majority of patients infected with H. pylori and carrying premalignant lesions do not develop GC. Therefore,it remains unclear who should be screened,when the screening should be started and how the screening should be performed. It seems reasonable that screening programs should target the general population in eastern countries,at high prevalence of GC and the high-risk subjects in western countries,at low prevalence of GC.As far as concern surveillance,currently,we are lacking of standardized international recommendations and many features have to be defined regarding the optimal diagnostic approach,the patients at higher risk,the best timing and the cost-effectiveness.Anyway,patients with corpus atrophic gastritis,extensive incomplete IM and dysplasia should enter a surveillance program.At present,screening and surveillance programs need further studies to draw worldwide reliable recommendations and evaluate the impact on mortality for GC. | Debora Compare Alba Rocco Gerardo Nardone | 2014 | World Journal of Gastroenterology2014，20，38： | 5 |
| 9 | 紫锥菊提取物对奶牛外周血单核细胞增殖的影响显示文摘[目的]为合理开发利用紫锥菊产品提供理论依据。[方法]以早期妊娠的荷斯坦奶牛为试验动物,采用ELISA方法检测不同浓度狭叶紫锥菊提取物(PolinaceaTM)(6.3、20.0、60.0、180.0μg/ml)体外结合刀豆蛋白A(ConA,1μg/ml)和美洲商陆有丝分裂原(PWM,0.6μg/ml)对其外周血单核细胞(PBMC)增殖的影响。[结果]不同浓度PolinaceaTM均能促进正常奶牛PBMC增殖,180.0、6.3μg/ml PolinaceaTM刺激PBMC增殖的结果分别较对照高了近10和2倍;不同浓度PolinaceaTM结合ConA均可抑制PBMC增殖,其中180.0μg/ml PolinaceaTM结合ConA对PBMC增殖具有显著抑制作用;20.0、60.0μg/ml PolinaceaTM结合PWM可显著刺激PBMC增殖。[结论]紫锥菊提取物对奶牛外周血单核细胞增殖的影响具有剂量依赖性。 | 吴华 Alessandro Nardone Nicola Lacetera | 2010 | 安徽农业科学2010，38，11： | 4 |
| 10 | Efficacy of 5-Day Levofloxacin-Containing Concomitant Therapy in Eradication of Helicobacter pylori Infection显示文摘 | Alessandro Federico Gerardo Nardone Antonietta G. Gravina Maria Rosaria Iovene Agnese Miranda Debora Compare Paola A. Pilloni Alba Rocco Luigi Ricciardiello Riccardo Marmo Carmelina Loguercio Marco Romano | 2012 | Gastroenterology2012，，1： | 3 |
| 11 | Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease显示文摘 | D. Compare P. Coccoli A. Rocco O.M. Nardone S. De Maria M. Cartenì G. Nardone | 2012 | Nutrition Metabolism and Cardiovascular Diseases2012，，6： | 3 |
| 12 | 皮质脊髓束参与肝硬化患者的肝门静脉分流:一项MEP研究显示文摘Hepatic myelopathy (HM) is a rare complication of chronic liver diseases usually associated with a portosystemic shunt, causing a progressive spastic parapare sis, and is likely to be overlooked. Thirteen patients with liver cir-rhosis associated with surgical or spontaneous portosystemic shunts were studied to determine the frequency and gravity of HM. Six patients exhibited clearcut signs of spinal cord involvement and four of them exhibited varying degrees of disability. Neurological examination did not reveal any abnormalities in the other patients. Motor evoked potentials (MEPs) were measured in all patients; in five of them the examinations were done before and after orthotopic liver transplantation (OLT). The patients with clinical signs of spinal cord involvement exhibited severe neurophysiological abnormalities, whereas milder but unequivocal MEP abnormalities were found in four of the seven patients with normal clinical examination. The clinical and neurophysiological features of patients with slight MEP abnormalities improved after OLT, whereas the patients with a more advanced stage of disease (severe MEPs abnormalities) did not. Our findings indicate that MEP studies may disclose an impairment of the corticospinal pathways even before HM is clinically manifest and provide evidence that early diagnosis of HM and subsequent immediate liver transplantation have to be recommended. | Nardone R. Buratti T. Oliviero A. 张殿增 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，6： | 2 |
| 13 | Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease显示文摘 | D. Compare P. Coccoli A. Rocco O.M. Nardone S. De Maria M. Cartenì G. Nardone | 2012 | Nutrition, Metabolism and Cardiovascular Diseases2012，，6： | 2 |
| 14 | Corticospinal involvement,in patients with a portosystemic shunt due to liver cirrhosis:a MEP study显示文摘 | Nardone R Buratti T Oliviero A | 2006 | J Neurol2006，253，1： | 1 |
| 15 | Assessment of De- sign Formulas for In-Plane FRP Strengthening of Masonry Walls显示文摘 | Prota A Man{redi G Nardone F | 2008 | Journal of Composites for Con- struction2008，12，6： | 1 |
| 16 | Effect of Helicobacter pylori infection and its eradication on cell proliferation,DNA status,and oncogene expression in patients with chronic gastritis显示文摘 | Nardone G Staibano S Rocco A | 1999 | Gut1999，44，6： | 1 |
| 17 | Subdural hematoma in a pa- tient with spontaneous intracranial hypotension and cerebral venous thrombosis显示文摘 | Nardone R Caleri F Golaszewski S | 2010 | Neurol Sci2010，31，5： | 1 |
| 18 | Transcriptional regulation by calcium, ealeineurin and NFAT显示文摘 | Hogan PG Chen L Nardone J | 2003 | Genes Dev2003，17，： | 1 |
| 19 | Fundamental properties and performance of conventional bearings-only target motion analysis显示文摘 | Nardone S C Lindgren A Gong K | 1984 | IEEE Trans on Automatic Control1984，29，9： | 1 |
| 20 | Amplification of padlock probes for DNA diagnostics by cascade rolling circle amplification or the polymerase chain reaction 显示文摘 | THOMAS D C NARDONE G A RANDALL S K | 1999 | Archives of Pathology & Laboratory Medicine1999，123，12： | 1 |
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