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| 1 | Proton pump inhibitor treatment of patients with gastroesophageal reflux-related chronic cough:A comparison between two different daily doses of lansoprazole显示文摘瞄准:为了比较 lansoprazole 的二不同一日量,给 12 个星期并且到估计角色胃肠(官方补给) 是的调查为选择病人的标准。方法:从 45 ,病人们为 unexplained 提交了长期的坚持的咳嗽, 36 有至少一官方补给的调查(内视镜检查法,食道的 pH-metry 和质子的4星期的试用抽的 24-h 禁止者( PPI )治疗)积极并且随机被分配收到 30 mg lansoprazole o.d 或 30 mg 为 12 个星期的 lansoprazole b.i.d 。症状在 PPI 测试(访问 2 ) 以后并且在 12 星期的 lansoprazole 治疗经期(访问 3 ) 以后在基线(访问 1 ) 被评估。结果:35 个病人完成了学习协议。报导的 21 个病人(60.0%) 没有二个治疗组之间的差别从他们的咳嗽完成地势(58.8% 和 61.1% 没在 30 mg lansoprazole 和 60 个 mg lansoprazole 组有咳嗽,分别地) 。在治疗的结束从他们的咳嗽有完全的地势的超过 80% 病人显示出积极回答到 PPI 测试。结论:12 星期甚至在标准一日量的 lansoprazole 治疗,在有长期的坚持的咳嗽的病人是有效的。对起始的 PPI 测试的积极回答似乎是为选择对治疗作出回应的病人的最好的标准。 | Fabio Baldi Roberta Cappiello Carlotta Cavoli Stefania Ghersi Francesco Torresan Enrico Roda | 2006 | World Journal of Gastroenterology2006，12，1： | 31 |
| 2 | Body weight, lifestyle, dietary habits and gastroesophageal reflux disease显示文摘While lifestyle modifications are currently used as firstline treatment for subjects with gastroesophageal reflux disease (GERD), the pathogenetic role of lifestyle factors and consequently, the efficacy of lifestyle measures is controversial. Our aim was to systematically review the pathogenetic link between overweight/ obesity, dietary habits, physical activity and GERD, and the beneficial effect of specific recommended changes, by means of the available literature from the 1999 to the present. Obesity, in particular, abdominal obesity, plays a key role in determining GERD symptoms and complications through mechanical and metabolic effects. Controlled weight loss (by diet or surgery) is effective in improving GERD symptoms. No definitive data exist regarding the role of diet and, in particular, of specific foods or drinks, in influencing GERD clinical manifestations. Moderate physical activity seems to be beneficial for GERD, while vigorous activity may be dangerous in predisposed individuals. In conclusion, being obese/overweight and GERD-specific symptoms and endoscopic features are related, and weight loss significantly improves GERD clinical-endoscopic manifestations. The role of dietary behavior, mainly in terms of specific dietary components, remains controversial. Mild routine physical activity in association with diet modifications, i.e. a diet rich in fiber and low in fat, is advisable in preventing reflux symptoms. | Davide Festi Eleonora Scaioli Fabio Baldi Amanda Vestito Francesca Pasqui Anna Rita Di Biase Antonio Colecchia | 2009 | World Journal of Gastroenterology2009，15，14： | 8 |
| 3 | Focus on acute diarrhoeal disease显示文摘Diarrhoea is an alteration of normal bowel movement characterized by an increase in the water content, volume, or frequency of stools. Diarrhoea needs to be classif ied according to the trends over time (acute or chronic) and to the characteristics of the stools (watery, fatty, inflammatory). Secretory diarrhoeas, mostly acute and of viral aetiology in more than 70% of cases, are by far the most important subtype of diarrhoeas in terms of frequency, incidence and mortality (over 2.5 million deaths/year in developing countries). Natural and synthetic opiates such as morphine, codeine, and loperamide which react with endogenous opiates (enkephalins, beta-endorphins, dynorphins) mainly act on intestinal motility and slow down transit. An antidiarrhoeal drug developed in recent years, racecadotril, acts as an enkephalinase inhibitor. Clinical studies have shown that it is just as effective as loperamide in resolving acute diarrhoea but with greater reduction in pain and abdominal distension. Some studies have explored the prevalence of diarrhoea in old age. An epidemiological study carried out in Italy by 133 General Practitioners on 5515 elderly outpatients reported a prevalence of diarrhoea, def ined according to the Rome criteria, of 9.1%. Infectious diseases (19%) and drug use (16%) were the most common causes of diarrhoea in old age. Regardless of the cause, the treatment of elderly patients with diarrhoea must include rehydration and nutritional support. Every year, more than 50 million tourists travel from industrialized countries to places where hygiene levels are poor. At least 75% of those travelling for short periods mention health problems, and in particular traveller's diarrhoea. | Fabio Baldi Maria Antonia Bianco Gerardo Nardone Alberto Pilotto Emanuela Zamparo | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 4 | Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study显示文摘 | Barbara Mostacci Monica Ferlisi Alessandro Baldi Antognini Claudia Sama Cristina Morelli Susanna Mondini Fabio Cirignotta | 2008 | Neurological Sciences2008，，4： | 1 |
| 5 | Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study显示文摘 | Barbara Mostacci Monica Ferlisi Alessandro Baldi Antognini Claudia Sama Cristina Morelli Susanna Mondini Fabio Cirignotta | 2008 | Neurological Sciences2008，，4： | 1 |
| 6 | Effects of oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders显示文摘在年轻人的 Pretherapy 精子 cryopreservation 当前为癌症病人在好临床的实践指南被包括。这份报纸的目的在有阴囊的瘤形成或 lymphoproliferative 混乱的病人是在精液上构画出不同 oncological 治疗的效果优秀的,基于一所大公共医院的 Cryopreservation 中心的 8 年的经验。有阴囊的瘤形成的 261 个病人和经历了化疗或放射疗法和 pretherapy 精液 cryopreservation 的有 lymphoproliferative 混乱的 219 个病人被评估。精子和神经质的参数(刺激滤泡的荷尔蒙(FSH ) , luteinizing 荷尔蒙(LH ) ,睾丸激素, inhibin B 层次) 被估计在以前并且在癌症治疗的结束以后的 6, 12, 18, 24 和 36 个月。与 lymphoproliferative 混乱比在病人与恶意的阴囊的瘤形成在病人在很大程度上在精子收集,基线 FSH 水平和精子集中的时候被损害。精子发生上的有毒的效果在在癌症治疗的结束以后的 6 和 12 个月仍然是明显的,当精液的参数的改进在 18 个月以后被观察时。在结论,精子集中的全面增加被记录在在病人的多数的癌症治疗的结束以后的大约 18 个月,就算预言各单个的盒子 ‘ 的进化不是可能的; priori' 。为这个原因, pretherapy 精液 cryopreservation 应该在所有年轻癌症病人被考虑。 | Cataldo Di Bisceglie Angela Bertagna Emanuela R Composto Fabio Lanfranco Matteo Baldi Giovanna Motta Anna M Barberis Emanuela Napolitano Elena Castellano Chiara Manieri | 2013 | Asian Journal of Andrology2013，15，3： | 0 |
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