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| 1 | Pandanus amaryllifolius leaf extract increases insulin sensitivity in high-fat diet-induced obese mice显示文摘Objective: To examine the effect of Pandanus amaryllifolius(P. amaryllifolius) leaf extract on the insulin resistance state in obese ICR mice.Methods: Obesity was induced in mice fed with high-fat diet(45% fat) for 12 weeks. After the first six weeks on the diet, the obese mice were administered with the water extract of P. amaryllifolius leaf at 125 and 250 mg/kg/day, respectively for another six weeks. At the5 th week of treatment, oral glucose tolerance test was conducted. After six weeks of treatment, the levels of blood glucose, serum insulin, leptin, adiponectin, and lipid profiles were determined. The liver, muscle and epididymal fat tissues were removed for measuring the biochemical parameters and protein expression, as well as histological examination.Results: Six weeks of treatment with P. amaryllifolius led to a significant reduction in the blood glucose level as well as improvement in the insulin resistance. P. amaryllifolius also increased the liver glycogen storage and serum adiponectin and decreased the serum leptin levels. A reduction in the serum and hepatic triglyceride, and non-esterified fatty acid levels was also observed. The histological examination showed that the obese mice treated with P. amaryllifolius reduced the lipid droplet in liver tissue and adipocyte size in epididymal fat tissue. The treatment also increased the protein expression of glucose transporter 4 in the muscle and fat tissues.Conclusions: The treatment with P. amaryllifolius could decrease several parameters of impaired glucose and lipid metabolism. To the best of our knowledge, this is the first report on the role of P. amaryllifolius leaf extract in alleviating the insulin dysfunction in obesity state. | Suphaket Saenthaweesuk Jarinyaporn Naowaboot Nuntiya Somparn | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，10： | 4 |
| 2 | Umbelliferone Improves an Impaired Glucose and Lipid Metabolism in High‐Fat Diet/Streptozotocin‐Induced Type 2 Diabetic Rats显示文摘 | Jarinyaporn Naowaboot Nuntiya Somparn Suphaket Saentaweesuk Patchareewan Pannangpetch | 2015 | Phytother. Res2015，，9： | 3 |
| 3 | Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice显示文摘Objective:To investigate the effect of Rhinacanthus nasutus(R.nasutus) leaf extract on impaired glucose and lipid metabolism in obese ICR mice.Methods:Obesity was induced in the male ICR mice by feeding them a high-fat diet(60 kcal%fat) for 12 weeks.After the first six weeks of the diet,the obese mice were administered with the water extract of R.nasutus leaves at 250 and 500 mg/kg per day for the next six weeks.Subsequently,the blood glucose,lipid profiles,insulin,leptin,and adiponectin levels were measured.The liver and adipose tissues were excised for histopathological examination and protein expression study.Results:After six weeks of the treatment,R.nasutus extract(at 250 and 500 mg/kg per day) was found to reduce the elevated blood glucose level,improve the insulin sensitivity,decrease the serum leptin,and increase the serum adiponectin levels.The obese mice treated with R.nasutus were found to have a reduction in the increased lipid concentrations in their serum and liver tissues.Moreover,treatment with R.nasutus reduced the fat accumulation in the liver and the large adipocyte size in the fat tissues.Interestingly,the administration with R.nasutus extract was marked by an increase in the hepatic peroxisome proliferators-activated receptor alpha,fat cell adiponectin,and glucose transporter 4 proteins.Conclusions:To the best of our knowledge,the present study is the first report on the impact of R.nasutus extract in improving the impaired glucose and lipid metabolism in high-fat diet-induced obesity in mice via stimulating the insulin sensitivity in the liver and adipose tissues. | Supaporn Wannasiri Pritsana Piyabhan Jarinyaporn Naowaboot | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，1： | 2 |
| 4 | Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice显示文摘Objective: To evaluate the insulin sensitivity action of ferulic acid(FA) in skeletal muscle and hypothalamus of high-fat diet(HFD)-induced obese mice. Methods: Obese mouse model was induced by HFD(45 kcal% lard fat) for 16 weeks. After 8 weeks of HFD feeding, these obese mice were orally treated with FA at doses of 25 and 50 mg/kg/day for 8 weeks. At the end of all treatments, the epididymal fat, pancreas, skeletal muscle and hypothalamus were removed for biochemical parameter and protein expression examinations. Results: FA treatment significantly decreased leptin level in fat tissue and insulin level in pancreas(P < 0.05). Interestingly, obese mice treated with FA increased the protein expressions of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and phosphorylated-protein kinase B in both muscle and brain(P < 0.05). The phosphorylations of adenosine monophosphate-activated protein kinase and acetyl-CoA carboxylase in muscle, and leptin receptor protein in hypothalamus were also increased(P < 0.05). The pancreatic islets histology showed smaller size in obese mice treated with FA compared to untreated obese mice. Conclusions: These findings indicate the beneficial effect of FA in improving insulin resistance in HFD-induced obese mice. These effects are probably mediated via modulating the insulin receptor substrate/phosphatidylinositol 3-kinase/protein kinase B or adenosine monophosphate-activated protein kinase pathways. | Jarinyaporn Naowaboot Pritsana Piyabhan Pholawat Tingpej Narongsuk Munkong Wason Parklak Patchareewan Pannangpetch | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，12： | 2 |
| 5 | Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice显示文摘 | X. Rong Y. Li K. Ebihara M. Zhao J. Naowaboot T. Kusakabe K. Kuwahara M. Murray K. Nakao | 2010 | Diabetologia2010，，8： | 2 |
| 6 | Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats显示文摘 | Jarinyaporn Naowaboot Patchareewan Pannangpetch Veerapol Kukongviriyapan Upa Kukongviriyapan Saowanee Nakmareong Arunporn Itharat | 2009 | Nutrition Research2009，，： | 1 |
| 7 | Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice显示文摘 | X. Rong Y. Li K. Ebihara M. Zhao J. Naowaboot T. Kusakabe K. Kuwahara M. Murray K. Nakao | 2010 | Diabetologia2010，，8： | 1 |
| 8 | Antihy- perglyccmic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats 显示文摘 | Naowaboot J Pannangpctch P Kukongviriyapan V | 2009 | Plant Foods Hum Nutr2009，64，2： | 1 |
| 9 | Mul- berry leaf extract stimulates glucose uptake and GLUT4 transloca- tion in rat adipocytes显示文摘 | Naowaboot J Pannangpetch P Kukongviriyapan V | 2012 | Am J Chin Med2012，40，1： | 1 |
| 10 | Mul-berry leaf extract stimulates glucose uptake and GLUT4 translo-cation in rat adipocytes显示文摘 | Naowaboot J Pannangpetch P Kukongviriyapan V | | 0，，01： | 1 |
| 11 | Mulberry leaf extract restores arterial pressure in streptozotocin-induced chro- nic diabetic rats显示文摘 | Naowaboot J Pannangpetch P Kukongviriyapan V | 2009 | Nutr Res2009，29，8： | 1 |
| 12 | Mulberry leaf extract restores arterial pressure in strepto- zotocin-induced chronic diabetic rats显示文摘 | Naowaboot J Pannangpetch P Kukongviriyapan V | 2009 | Nutr Res2009，29，8： | 1 |
| 13 | Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats显示文摘 | Naowaboot J Pannangpetch P Kukongviriyapan V | 2009 | Nutrition Research2009，29，： | 1 |
| 14 | Mulberry leaf extract increases adiponectin in murine 3T3-L1 adipocytes显示文摘 | Jarinyapom Naowaboot Choon Hee Chung Patchareewan Pannangpetch | 2012 | Nutrition Research2012，32，1： | 1 |
| 15 | Mulberry leaf extract increases adiponectin in murine 3T3-L1 adipocytes显示文摘 | Naowaboot J Chung C H Pannangpetch P | 2012 | Nutrition Research2012，32，1： | 1 |
| 16 | Mulberry leaf extract restores arterial pressure in streptozotocin-indueed chro- nic diabetic rats 显示文摘 | Naowaboot J Pannangpetch P Kukongviriyapan V | 2009 | Nutr Res2009，29，8： | 1 |
| 17 | Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice显示文摘 | X. Rong Y. Li K. Ebihara M. Zhao J. Naowaboot T. Kusakabe K. Kuwahara M. Murray K. Nakao | 2010 | Diabetologia2010，，8： | 1 |
| 18 | Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats 显示文摘 | Naowaboot J Pannangpetch P Kukongviriyapan V | 2009 | N utr Res2009，29，8： | 1 |
| 19 | Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats显示文摘 | Jarinyaporn Naowaboot Patchareewan Pannangpetch Veerapol Kukongviriyapan Bunkerd Kongyingyoes Upa kukongviriyapan | 2009 | Plant Foods for Human Nutrition2009，，2： | 1 |
| 20 | Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice显示文摘Objective: To examine the effect of Senna alata(S. alata) leaf extracts on the regulation of lipid metabolism in high-fat diet-induced obese mice.Methods: The obesity condition was induced in the male ICR mice by feeding them with high-fat diet(45 kcal% fat) for 12 weeks. At the 7th week of diet feeding, the obese mice were treated with the water extract of S. alata leaf at 250 and 500 mg/kg/day, respectively, that continued for six weeks. At the end of the treatment period, the biochemical parameters were determined. The hepatic histology and the gene and protein expressions were also examined.Results: In comparison with the obese control mice, the mice treated with S. alata showed a significant reduction in the elevated blood glucose levels and a decrease in the serum insulin and leptin levels. A reduction in the serum total cholesterol, triglyceride,non-esterified fatty acid, and hepatic triglyceride levels were also observed. The histological examination of the obese mice treated with S. alata showed a reduced lipid accumulation in the liver tissue. Hepatic lipogenic gene expression showed that S. alata decreased the activity of sterol regulatory element binding protein 1c, fatty acid synthase,and acetyl-Co A carboxylase. S. alata could suppress hepatic peroxisome proliferatoractivated receptor gamma(PPARg) protein. Moreover, the protein expression of PPARa in liver tissue was clearly increased by S. alata treatment.Conclusion: The treatment with S. alata could decrease several parameters of impaired lipid metabolism in the obese mice by downregulating sterol regulatory element binding protein 1c and PPARg and upregulating PPARa. This study is the first report on the role of S. alata leaf extract in alleviating the abnormal lipid metabolism in obese conditions. | Jarinyaporn Naowaboot Supaporn Wannasiri | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，3： | 1 |
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