| 2 | Development of self-micellizing solid dispersion system employing amphipathic copolymer for the improvement of dissolution and oral bioavailability of cyclosporine A显示文摘The main objective of the present study is to develop a selfmicellizing solid dispersion(SMSD)system of cyclosporine A(CsA)using an amphiphilic copolymer,poly[MPC-co-BMA](pMB)to improve the biopharmaceutical properties of CsA(Fig.1A).Unlike conventional carrier compounds,pMB would perform the bifunctional ability as both polymeric carrier of solid dispersion system and solubilizer derived from a high micellizing property,which could be considered beneficial for the production of highly water soluble formulation of poorly water soluble compound[1].Improvement in the aqueous solubility has been believed to be a key consideration for acquiring potent pharmacological effects of BCS class II drug like CsA. | Hiroki Suzuki Hideyuki Sato Yoshiki Kojo Takahiro Mizumoto Kayo Yuminoki Naohumi Hashimoto Yoshiki Seto Satomi Onoue | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
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