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| 1 | Phytochemical analysis and anticancer capacity of Shemamruthaa,a herbal formulation against DMBA-induced mammary carcinoma in rats显示文摘Objective:To investigate the bioactive-constituents of Shemamruthaa(SM),a herbal combination and its therapeutic effects on the mitochondrial functions with reference to lipid peroxidation(LPO),antioxidant status,citric acid cycle enzymes and electron transport chain enzymes in mammary tissues of 7,12-dimethylbenz(a)-anthracene(DMBA)induced mammary carcinoma in rat model.Methods:Adult Female Sprague-Dawley rats were used for the study and were divided into four groups.CroupⅠserved as control and CroupⅡrats were induced mammary carcinoma by administration of DMBA(25 mg/kg b.w.)orally.The normal and cancer-induced rats(GroupⅢ)were treated with SM(400 mg/kg b.w./day)orally by gastric incubation for 14days.CroupⅣrats served as SM-treated control animals.Results:Cancer-induced rats showed a considerably increased level of LPO with concomitant decreased levels of antioxidants,citric acid cycle enzymes,electron transport chain enzymes and cytochrome contents in the mammary tissue.Treatment with SM brought back the aforementioned biochemical parameters to near normal.Conclusions:From the results,it can be inferred that Shemamruthaa possesses significant anticancer effect through its role in attenuation of LPO,prevention of membrane damage and restoring membrane integrity. | Ayyakkannu Purushothaman Elumalai Nandhakumar Panchanatham Sachdanandam | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，12： | 6 |
| 2 | Facile Synthesis of the Uryl Pendant Binaphthol Aldehyde and Its Selective Fluorescent Recognition of Tryptophan 显示文摘 | Tang L Wei G Nandhakumar R | 2011 | Bull Korean Chem Soc2011，32，： | 1 |
| 3 | Nanotemplated lead telluride thin films 显示文摘 | LI Xiao-hong Nandhakumar I S Attard G S | 2009 | Microporous and Mesoporous Materials2009，118，13： | 1 |
| 4 | Synthesis of novel H8-binaphthol-based chiral receptors and their applications in enantio- selective recognition of 1,2-amino alcohols and chirality conversion of L-amino acids to D- amino acids显示文摘 | Jung H Nandhakumar R Yoon H-J | 2010 | Bull Korean Chem Soc2010，31，： | 1 |
| 5 | Muhiaperture ultrawideband SAR processing with polarimetric diversity 显示文摘 | Ravinder Kapoor Nagaraj Nandhakumar | 1995 | SPIE1995，2487，： | 1 |
| 6 | Natural rubber latex/potato starch nanocrystal nanocomposites: Correlation morphology/electrical properties显示文摘 | Emilie Bouthegourd K.R. Rajisha Nandhakumar Kalarical Jean Marc Saiter Sabu Thomas | 2011 | Materials Letters2011，，23： | 1 |
| 7 | On the computation of motion from sequences of images-review 显示文摘 | Aggarwal J K Nandhakumar N | 1988 | IEEE1988，76，8： | 1 |
| 8 | Unified 3D models for multisensor image synthesis显示文摘 | Nandhakumar N | 1995 | Graphical Models and Image Progressing1995，57，4： | 1 |
| 9 | Reactive extraction of enanti- omers of 1,2 - amino alcohols via stereoselective thermodynamic and kinetic processes显示文摘 | Tang L Choi S Nandhakumar R | 2008 | Journal of Organic Chemistry2008，73，15： | 1 |
| 10 | Electrochemical synthesis of nanostructured tellurium films 显示文摘 | GABRIEL T NANDHAKUMAR I S ATTARD G S | 2002 | Electrochem Comm2002，4，8： | 1 |
| 11 | Novel PLGA-based nanoparticles for the oral deliveff of insulin 显示文摘 | Malathi S Nandhakumar P Pandiyan V | 2015 | lnt J Nanomedi-citle2015，10，： | 1 |
| 12 | Interpretations; How to use faecaldiastase testing 显示文摘 | Nandhakumar N Green MR | 2010 | Arch Dis Child Educ Pract Ed2010，95，4： | 1 |
| 13 | Reactive extraction of enantiomers of 1,2-amino alcohols via stereoselective thermodynamic and kinetic processes 显示文摘 | TANG L J CHOI S J NANDHAKUMAR R J | 2008 | J Organic Chem2008，73，15： | 1 |
| 14 | View-invariant regions and mobile robot self-localization显示文摘 | OLSON T J NANDHAKUMAR N | 1996 | IEEE Trans on Robotics and Automation1996，12，5： | 1 |
| 15 | Evaluation of DNA damage using single-cell gel electrophoresis (Comet Assay)显示文摘 | Nandhakumar S Parasuraman S Shanmugam MM | 2011 | J Pharmacol Pharmacother2011，2，2： | 1 |
| 16 | The impact of enterprise systems on organizational resilience显示文摘 | Ignatiadis I Nandhakumar J | 2007 | Journal of Infor- mation Technology2007，22，： | 1 |
| 17 | Electrodeposition of Nanostructured Mesoporous Selenium Films (HI-eSe)显示文摘 | Nandhakumar I Elliott J M Attard G S | 2001 | Chem Mater2001，13，： | 1 |
| 18 | Unified 2D models for multisensor image synthesis显示文摘 | MICHEL J NANDHAKUMAR N | 1995 | Graphical Models and lnmge Progresang1995，57，4： | 1 |
| 19 | The impact of enterprise systems on organizational resilience 显示文摘 | Ignatiadis I Nandhakumar J | 2007 | Journal of In- formation Technology2007，22，1： | 1 |
| 20 | 一种基于联二萘酚衍生物的荧光传感器对铜离子的荧光识别显示文摘设计并合成了一种基于联二萘酚衍生物的荧光传感器1,1在乙腈溶液中对Cu^(2+)具有很好的选择性和灵敏度。当所加金属离子的浓度为1的10倍的时候,只有Cu^(2+)能显著猝灭1的荧光,而其它离子(Hg^(2+),Pb^(2+),Sr^(2+),Ba^(2+),Cd^(2+),Ni^(2+),Co^(2+),Fe^(2+),Mn^(2+),Zn^(2+),Ce^(3+),Mg^(2+),K^+,Fe^(3+),Cr^(3+),Na^+)仅能引起1的荧光发射强度略微下降。结合比实验证明1与Cu^(2+)是以1:2的方式结合,通过Benesi-Hildebrand方程计算得出其表观结合常数为4.09×10^(10)M^(-2)。 | 郭志龙 汤立军 魏恭繁 Raju Nandhakumar | 2011 | 渤海大学学报(自然科学版)2011，32，1： | 1 |
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