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| 1 | 1 H-吡咯-2,5-二酮(马来酰亚胺):油气地球化学中的新生物标志物显示文摘1 H-吡咯-2,5-二酮(马来酰亚胺)是发现于石油以及土壤、沉积物和沉积岩中四吡咯色素的降解产物或衍生物,其中2-甲基-3-正丙基(Me,n-Pr)和2-甲基-3-异丁基(Me,i-Bu)马来酰亚胺主要来源于光合硫细菌体内的细菌叶绿素。将不同来源和成因的石油中分离出马来酰亚胺组分,并运用气相色谱-质谱(GC-MS)和全二维气相色谱-飞行时间质谱(GC×GC-ToFMS)进行分析鉴定,结果表明,在中国湖相原油中发育3类不同系列的马来酰亚胺,且不同成因的原油中马来酰亚胺组成存在显著差别。丰富的Me,nPr和Me,i-Bu马来酰亚胺主要分布于咸化、水体存在永久性分层的渤海湾盆地沙河街组四段上部烃源岩生成的原油中,在微咸水或淡水条件下形成的原油中二者均不发育。同时,Me,n-Pr和Me,i-Bu马来酰亚胺可以有效地应用于判识透光滞水带(PZE)的出现和进行油源对比。马来酰亚胺有望成为油气地球化学中一类新的非烃类生物标志物。 | 王广利 Sebastian Naeher 李婧仪 师生宝 常睿 | 2019 | 石油学报2019，40，2： | 4 |
| 2 | Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations显示文摘The assessment of occupational exposure to diesel exhaust(DE) is important from an epidemiological perspective. Urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene(1NP), a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples(10 m L) from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, Peru, before and after their workshifts. Workshift exposures to1 NP, as well as PM_(2.5), 2-nitropyrene and 2-nitrofluoranthene, were also measured.Exposures to 1NP were similar in all studied workers, averaging 105 ± 57.9 pg/m^3(±standard deviation). Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects(n = 17) studied. A direct relationship between workshift exposure to 1NP and urinary 1NP metabolites concentrations was not observed. However,the 1NP exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these Peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle exhaust.This study provides further evidence that urinary metabolites of 1NP are associated with exposure to DE and may serve as a useful exposure biomarker. | Justin P.Miller-Schulze Michael Paulsen Takayuki Kameda Akira Toriba Kazuichi Hayakawa Brandon Cassidy Luke Naeher Manuel Aguilar Villalobos Christopher D.Simpson | 2016 | Journal of Environmental Sciences2016，28，11： | 2 |
| 3 | Effect of zinc in enteropathogenic Escherichia coli infection显示文摘 | Crane JK Naeher TM Shulgina I | 2007 | Infect Immun2007，75，12： | 1 |
| 4 | A review of traffic-related air pollution exposure assessment studies in the developing world 显示文摘 | Han XL Naeher LP | 2006 | Environ Int2006，32，： | 1 |
| 5 | Particulate matter and carbon monoxide in highland Guatemala: indoor and outdoor levels from traditional and improved wood stoves and gas stoves显示文摘 | Naeher L P Leaderer B P Smith K R | 2000 | Indoor Air2000，10，： | 1 |
| 6 | Signaling life and death in the thymus: timing is everything 显示文摘 | Werlen G Hausmann B Naeher D | 2003 | Science2003，299，： | 1 |
| 7 | Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city 显示文摘 | Naeher LP Tulve NS Egeghy PP | 2010 | Sci Total Environ2010，408，5： | 1 |
| 8 | Intratracheal transplantation of alveolar type ceils reverses bleomyein-induced lung fibrosis显示文摘 | Serrano-Mollar A Naeher M Gay-Jordi G | 2007 | Am J Respir Crit Care Med2007，176，12： | 1 |
| 9 | Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city显示文摘 | Naeher LP Tulve NS Egeghy PP | 2010 | Sci Total Environ2010，408，5： | 1 |
| 10 | Use of the incretin hormone glucagon-like peptide-1 (GLP-1) for the detection of insulinomas:initial experimental results显示文摘 | Cotthardt M Fischer M Naeher I | 2002 | Eur J Nuel Med Mol Imaging2002，29，5： | 1 |
| 11 | A review of traffic-related air pollution exposure assessment studies in the developing world 显示文摘 | Han X L Naeher L P | 2006 | Environment International2006，32，： | 1 |
| 12 | Use of isotope ratios to identify sources contributing to pediatric lead poisoning in Peru 显示文摘 | Naeher L P Rubin C S Hernandez A M | 2003 | Arch Environ Health2003，58，9： | 1 |
| 13 | Carbon monoxide as a tracer for assessing exposures to particulate matter in wood and gas cookstove households of highland Guatemala显示文摘 | Naeher L P Smith K R Leaderer B P | | 0，，03： | 1 |
| 14 | Mutual enhancement of virulence by enterotoxigenic and enteropathogenic Escherichia coli 显示文摘 | Crane JK Choudhari SS Naeher TM | 2006 | Infect Immun2006，74，3： | 1 |
| 15 | A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation 显示文摘 | Naeher D Luescher I F Palmer E | 2002 | J Immunol2002，169，6： | 1 |
| 16 | A review of traffic-related air pollution exposure assessment studies in the developing world显示文摘 | Han X L Naeher L P | 2006 | Envi- ronment International2006，32，1： | 1 |
| 17 | A role for the α-chain connecting peptide motif in mediating TCR-CD8 cooperation 显示文摘 | Dieter Naeher Immanuel F L Palmer E D | 2002 | J Immunol2002，169，： | 1 |
| 18 | A pilot study to assess ground-level ambient air concentrations of fine particles and carbon monoxide in urban Guate- mala显示文摘 | Shendell D G Naeher L P | 2002 | Environment International2002，28，5： | 1 |
| 19 | Structurally robust control of complex networks显示文摘 | Naeher J C | 2015 | Physical Review E2015，91，01： | 1 |
| 20 | Network medicine analysis of chondrocyte proteins towards new treatments of osteoarthritis 显示文摘 | Naeher J C Keith B Schwartz J M | 2014 | Proc Biol Sci2014，281，20： | 1 |
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