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| 1 | Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review显示文摘BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with sorafenib.CASE SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease response.CONCLUSIONDT's pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used. | Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Clinical Oncology2019，10，4： | 4 |
| 2 | Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment显示文摘Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular proteins.In addition,HDACs have also been associated with increased chemotherapy resistance.Based on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free survival.The aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer. | Dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou George Bagias Dimitrios Moris | 2018 | World Journal of Gastroenterology2018，24，41： | 3 |
| 3 | Paclobutrazol and Its Use in Fruit Production:A Review显示文摘There are documentary records referring to paclobutrazol(PBZ)as a growth bioregulator that inhibits the gibberellin synthesis and its application increases yields in fruit and vegetable crop productions.Its agronomic management includes it as an emerging technology to reduce vigour,promote flower induction and flower development in fruit trees with increased economic returns.Its use is banned in some countries because of concerns about residues that can cause harmful effects on the environment.Therefore,the aim of this article was to collect,analyse and summarise relevant information on the use of PBZ in fruit tree production and its possible risks to the environment.The results obtained indicated that the application of PBZ can be effective in solving some problems related to flowering if it is applied in the right amount and at the right time.However,it is necessary to elucidate the physiological processes with which it is associated and its response to be taken into account to increase yield.PBZ is currently used in fruit trees such as mango,lime,apple and guava,increasing their productivity.However,some studies have shown its residual effect on the environment.Therefore,PBZ is a viable strategy,because it presents a series of advantages in the production of fruit trees.However,it is vital to generate protocols that seek its regulation with a rational and sustainable approach. | Laura Raquel Orozco-Meléndez Ofelia Adriana Hernández-Rodríguez Oscar Cruz-Álvarez Loreto Robles-Hernández Graciela Dolores Avila-Quezada Esteban Sánchez Chavez DamiánAarón Porras-Flores Dámaris Leopoldina Ojeda-Barrios | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 2 |
| 4 | An orthodontic patient administration system (OPAS)for complete departmental management显示文摘 | Naar JH Shupac M | 2001 | J Orthod2001，28，1： | 1 |
| 5 | Comparison of the crashworthincss of various bottom and side structures显示文摘 | Naar H Kujala P Simonscn B C etc | 2002 | Marine Structure2002，15，： | 1 |
| 6 | Comparison of the crashworthiness of various bottom and side structures显示文摘 | Naar H Kujala P Simonsen B | 2002 | Marine Structures2002，15，： | 1 |
| 7 | MicroRNAs in metabolism and metabolic disorders显示文摘 | Rottiers V Naar AM | 2012 | Nat Rev Mol Cell Biol2012，13，4： | 1 |
| 8 | Coastal bathymetry from hyperspectral remote sensing data: comparisons with high resolution multibeam bathymetry显示文摘 | McIntyre M L Naar D F Carder K L | 2006 | Marine Geophysical Re searches2006，27，2： | 1 |
| 9 | A competitive ELISA to detect brevetoxins from Karenia brevis (formerly Gymnodinium breve) in seawater, shellfish, and mammalian body fluid 显示文摘 | Naar J Bourdelais A Tomas C | 2002 | Environ Health Persp2002，110，： | 1 |
| 10 | A Benthic Terrain Classification Scheme for American Samoa显示文摘 | Emily R. Lundblad Dawn J. Wright Joyce Miller Emily M. Larkin Ronald Rinehart David F. Naar Brian T. Donahue S. Miles Anderson Tim Battista | 2006 | Marine Geodesy2006，，2： | 1 |
| 11 | Comparison of the crashworthiness of various bottom aud side structures显示文摘 | Hendrik Naar | 2002 | Marine Structures2002，，12： | 1 |
| 12 | MicroRNAs in metabolism and metabolic disorders 显示文摘 | Rottiers V Naar AM | 2012 | Nat Rev Mol Cell Biol2012，13，5： | 1 |
| 13 | Comparison of the crashworthiness of various bottom and side structures显示文摘 | Naar H Kujala P Simonsen B C | 2002 | Marine Structures2002，15，45： | 1 |
| 14 | Ligand-independent repressor by the thyroid hormone receptor mediatated by a nuclear receptor co-repressor see comments显示文摘 | Horlein AJ Naar AM Heinzel T | 1995 | Nature1995，377，6548： | 1 |
| 15 | Intragraft cytokine expression in tolerant rat renal allografts with rapamycin and cyclosporine im- munosuppression显示文摘 | Saggi BH Fisher RA Naar JD | 1999 | Clin Transplant1999，13，1： | 1 |
| 16 | Low-grade cartilage tumors:diagnosis and treatment显示文摘 | Ryzemicz M Manaster BJ Naar E | | 0，，1： | 1 |
| 17 | Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor显示文摘 | Horlein AJ Naar AM Heinzel T | 1995 | Nature1995，377，6548： | 1 |
| 18 | Comparison of the crashworthiness of various bottom and side structures 显示文摘 | NAAR H KUJALA P SIMONSEN B | 2002 | Marine Structures2002，15，： | 1 |
| 19 | Comparison of the crashworthiness of various bottom and side structures显示文摘 | Naar H Kujala P Simonsen B C | 2002 | Marine Structures2002，15，4： | 1 |
| 20 | Does the red tide dinoflagellate Karenia brevis use allelopathy to outcompete other phytoplankton? 显示文摘 | Kubanek J Hicks M Naar J | 2005 | Limnol Oeeanogr2005，50，3： | 1 |
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