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| 1 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 2 | Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues显示文摘Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. | Dominik Bettenworth Tobias M Nowacki Friederike Cordes Boris Buerke Frank Lenze | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 3 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 4 | Pressurized intraperitoneal aerosol chemotheprapy after misdiagnosed gastric cancer: case report and review of the literature显示文摘We report the first application of pressurized intraperitoneal aerosol chemotherapy(PIPAC) as a rescue therapy before palliative D2 gastrectomy combined with liver metastasectomy performed in a 49-yearold woman with peritoneal carcinomatosis who was primarily diagnosed with and underwent surgery for a Krukenberg tumor. The PIPAC procedure was performed with the use of cisplatin at 7.5 mg/m2 and doxorubicin at 1.5 mg/m2 for 30 min at 37 ℃. Eight weeks after the PIPAC procedure, the patient underwent open classic D2 gastrectomy with the creation of a Roux-en-Y anastomosis(RNY) combined with liver metastasectomy. The patient underwent the classic protocol for chemotherapy combined with Xeloda. The patient felt better and returned to her daily activities. Multicenter data should be gathered to confirm the usefulness of PIPAC as a rescue or neoadjuvant supportive therapy in a very select group of patients who have been recently qualified to undergo classic chemotherapy or standard oncologic surgical procedures. | Maciej Nowacki Dariusz Grzanka Wojciech Zegarski | 2018 | World Journal of Gastroenterology2018，24，19： | 3 |
| 5 | Capecitabine as adjuvant treatment for stage Ⅲ colon cancer显示文摘 | TWELVES C WONG A NOWACKI M P | 2005 | N Engl J Med2005，352，26： | 1 |
| 6 | Possibility of determining steel grain size using ultrasonic waves 显示文摘 | NOWACKI K | 2009 | METABK2009，48，2： | 1 |
| 7 | The shell model as a unified view of nuclear structure 显示文摘 | Caurier E Martinez-Pinedo G Nowacki F | 2005 | Reviews of Modern Physics2005，77，2： | 1 |
| 8 | Deformability of WC/Co sinters and 17-4PH steel brazed joints显示文摘 | Nowacki J Kawiak M | 2004 | J Mater Process Technol2004，157，7： | 1 |
| 9 | Saponins of the genus Medicago显示文摘 | Jurzysta M Nowacki E | 1979 | Acta Agrobot1979，32，： | 1 |
| 10 | Evaluation of IGF-1 concentration in serum and synovial fluid in women with different type coxarthrosis 显示文摘 | Lis K Odrowaz-Sypniewska G Nowacki W | 2005 | Chir Narzadow Ruchu Ortop Pol2005，70，6： | 1 |
| 11 | Capecitabine as adjuvant treatment for stage Ⅲ colon cancer显示文摘 | Twelves C Wong A Nowacki MP | | 0，，： | 1 |
| 12 | Approximate conversion of surface representations with polynomial bases显示文摘 | Danneberg L Nowacki H | 1985 | Computer Aided Geometric Design1985，2，2： | 1 |
| 13 | Saponins of the genus Medicago显示文摘 | Jurzysta M Nowacki E | 1979 | Acta Agrobotanica1979，32，： | 1 |
| 14 | Evaluating a museum as a tourist pro-duct using the servqual method显示文摘 | | 2005 | Museum Management and Quratorship2005，20，： | 1 |
| 15 | Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer 显示文摘 | Bujko K Nowacki MP Nasierowska-Guttmejer A | 2006 | Br J Surg2006，93，10： | 1 |
| 16 | Some general theorems of thermopizeoelectricity 显示文摘 | Nowacki W | 1978 | Journal of Thermal Stresses1978，1，1： | 1 |
| 17 | Some general theorems of thermopiezoeleetrieity显示文摘 | NOWACKI W | 1978 | Journal of Thermal Stresses1978，1，2： | 1 |
| 18 | Temperature evolution in deformed shape memory alloy显示文摘 | Gadaj S P Nowacki W K Pieczyska E A | 2002 | Infrared Physics & Technology2002，43，3： | 1 |
| 19 | Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress显示文摘 | Malpuech Brugere C Nowacki W Gueux E | | 0，，05： | 1 |
| 20 | Microstructural transformations of heat affected zones in duplex steel welded joints 显示文摘 | Jerzy Nowacki Aleksander Lukojc | 2006 | Materials Characterization2006，56，45： | 1 |
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