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| 1 | Wnt/β-catenin signalling:function,biological mechanisms,and therapeutic opportunities显示文摘The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.The deregulation of Wnt/β-catenin signalling often leads to various serious diseases,including cancer and non-cancer diseases.Although many articles have reviewed Wnt/β-catenin from various aspects,a systematic review encompassing the origin,composition,function,and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking.In this article,we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.Finally,we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment. | Jiaqi Liu Qing Xiao Jiani Xiao Chenxi Niu Yuanyuan Li Xiaojun Zhang Zhengwei Zhou Guang Shu Gang Yin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 28 |
| 2 | Sex- and region- specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin -4 knockout mice显示文摘 | Yi Fan Jing Zhang Xiu - Lan Sun Lin Gao Xiao - Ning Zeng Jian - Hua Ding Cong Cao Ling Niu Gang Hu | 2005 | 中国药理通讯2005，22，4： | 14 |
| 3 | Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice显示文摘Objective To determine the ability of grape seed proanthocyanidin extract(GSPE) in alleviating arsenic-induced reproductive toxicity. Methods Sixty male Kunming mice received the following treatments by gavage: normal saline solution(control); arsenic trioxide(ATO; 4 mg/kg); GSPE(400 mg/kg); ATO+GSPE(100 mg/kg); ATO+GSPE(200 mg/kg) and ATO+GSPE(400 mg/kg). Thereafter, the mice were sacrificed and weighed, and the testis was examined for pathological changes. Nuclear factor(erythroid-derived 2)-like 2(Nrf2), heme oxygenase 1(HO1), glutathione S-transferase(GST), NAD(P)H dehydrogenase, and quinone 1(NQO1) expression in the testis was detected by real-time PCR. Superoxide dismutase(SOD), glutathione(GSH), total antioxidative capability(T-AOC), malondialdehyde(MDA), 8-hydroxydeoxyguanosine(8-OHd G), and reproductive indexes were analyzed. Results ATO-treated mice showed a significantly decreased sperm count and testis somatic index and activity levels of SOD, GSH, and T-AOC than control group. Compared to the ATO-treated group, ATO +GSPE group showed recovery of the measured parameters. Mice treated with ATO+high-dose GSPE showed the highest level of m RNA expression of Nrf2, HO, NQO1, and GST. Conclusion GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. | LI Shu Gang DING Yu Song NIU Qiang XU Shang Zhi PANG Li Juan MA Ru Lin JING Ming Xia FENG Gang Ling LIU Jia Ming GUO Shu Xia | 2015 | Biomedical and Environmental Sciences2015，28，4： | 14 |
| 4 | Quantitative computed tomography analysis for stratifying the severity of Coronavirus Disease 2019显示文摘To examine the feasibility of using a computer tool for stratifying the severity of Coronavirus Disease 2019(COVID-19)based on computed tomography(CT)images.We retrospectively examined 44 confirmed COVID-19 cases.All cases were evaluated separately by radiologists(visually)and through an in-house computer software.The degree of lesions was visually scored by the radiologist,as follows,for each of the 5 lung lobes:0,no lesion present;1,<1/3 involvement;2,>1/3 and<2/3 involvement;and 3,>2/3 involvement.Lesion density was assessed based on the proportion of ground-glass opacity(GGO),consolidation and fibrosis of the lesions.The parameters obtained using the computer tool included lung volume(mL),lesion volume(mL),lesion percentage(%),and mean lesion density(HU)of the whole lung,right lung,left lung,and each lobe.The scores obtained by the radiologists and quantitative results generated by the computer software were tested for correlation.A Chi-square test was used to test the consistency of radiologist-and computer-derived lesion percentage in the right/left lung,upper/lower lobe,and each of the 5 lobes.The results showed a strong to moderate correlation between lesion percentage scores obtained by radiologists and the computer software(r ranged from 0.7679 to 0.8373,P<0.05),and a moderate correlation between the proportion of GGO and mean lesion density(r=-0.5894,P<0.05),and proportion of consolidation and mean lesion density(r=0.6282,P<0.05).Computer-aided quantification showed a statistical significant higher lesion percentage for lower lobes than that assessed by the radiologists(x^2=8.160,P=0.004).Our experiments demonstrated that the computer tool could reliably and accurately assess the severity and distribution of pneumonia on CT scans. | Cong Shen Nan Yu Shubo Cai Jie Zhou Jiexin Sheng Kang Liu Heping Zhou Youmin Guo Gang Niu | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 13 |
| 5 | Experimental investigation of boundary layer transition over a delta wing at Mach number 6显示文摘An experimental study on the boundary layer transition over a delta wing was carried out at Mach number 6 in a quiet wind tunnel.The Nano-tracer-based Planar Laser Scattering(NPLS)and Temperature-Sensitive Paints(TSP)techniques were used to measure the fine flow field structure and the wall Stanton number of the delta wing.The influence of factors such as the angle of attack and the Reynolds number was studied.The following results were obtained.The boundary layer transition between the leading edge and the centerline was dominated by the crossflow instability.At the location of the initial appearance of the traveling crossflow waves,the Stanton number began to rise.The Stanton number reached a maximum when the crossflow waves were broken up to turbulence.Increasing the angle of attack increased the spanwise pressure gradient at the windward side of the delta wing,thereby increasing the crossflow instability and advancing the boundary layer transition front.However,increasing the angle of attack caused the transition front to move backward at the leeward side.In addition,the sensitivity of the boundary layer transition to the Reynolds number varied with the angle of attack and the region. | Haibo NIU Shihe YI Xiaolin LIU Xiaoge LU Dundian GANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 9 |
| 6 | Discovery of ~4.0 Ga detrital zircons in the Aermantai ophiolitic mélange,East Junggar,northwest China显示文摘The East Junggar is an important part of the Central Asian Orogenic Belt(CAOB).Using in situ zircon dating and Hf isotopic analysis by LA-ICP-MS and MC-ICP-MS,respectively,a detrital zircon of 4040 Ma age was found in sedimentary sequences from the Aermantai ophiolitic mélange,East Junggar.This is the oldest age record in the East Junggar terrane,and also marks the first zircon locality in the CAOB with an age older than 4.0 Ga,which is attributed to the Hadean crust.The 4040 Ma detrital zircon has anεHf(t)value of–5.2 and a two-stage Hf modal age of 4474 Ma,suggesting the presence of very old(Hadean)crustal material in the source area.Beside peak ages of 446 Ma,we found four age groups of 3.6–3.1 Ga,2.53–2.37 Ga,1.14–0.89 Ga and 0.47–0.42 Ga from 141 effective measuring points.The age of 426±4 Ma for the five youngest detrital zircons defines the lower limit of the deposition time of sedimentary sequencess in the Aermantai ophiolitic mélange.The 0.47–0.42 Ga zircons exhibit176Hf/177Hf ratios of 0.282156 to 0.282850,corresponding to variableεHf(t)values from–9.3 to 12.0 and Hf model ages from2011 to 646 Ma.These characteristics are similar to those of the early Paleozoic igneous and gneissic zircons from the Altai,but significantly different from those of the East Junggar.Based on the material structures of felspathic greywacke,the morphology,internal texture and age distributions of dated detrital zircons,in combination with a study of the regional geological data,it is suggested that the sedimentary sequences in the Aermantai ophiolitic mélange was deposited in the Late Silurian,with the main provenance from the Altai Orogen in the north.This indicates that the early Paleozoic ocean represented by the Aermantai ophiolitic mélange was readily closed during the Late Silurian,and the northern edge of the East Junggar terrane was accreted to the Altai Orogen.The joint of them then served as a marginal orogen in the southern edge of the Siberia Paleocontinent. | HUANG Gang NIU GuangZhi ZHANG ZhanWu WANG XinLu XU XueYi GUO Jun YU Feng | 2013 | Chinese Science Bulletin2013，58，30： | 9 |
| 7 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 8 | A Novel Surgery Classification for Endoscopic Approaches to Middle Ear Cholesteatoma显示文摘This study aimed to develop a novel surgery classification for an endoscopic approach to middle ear cholesteatoma.We retrospectively analyzed the surgical approaches and outcomes of patients with middle ear cholesteatoma.Middle ear cholesteatoma surgeries were divided into four types and two special types as follows:type I,attic retraction pocket,which only requires tympanostomy tube placement or retraction pocket resection and cartilage reconstruction;typeⅡ,cholesteatoma which is limited to the attic or in which endoscopy can confirm complete removal of mastoid cholesteatoma lesions,including type Ⅱa,requiring only use of a curette,and type Ⅱ b,requiring use of an electric drill or chisel;type Ⅲ,cholesteatoma not limited to the attic,in which endoscopy cannot confirm complete removal of mastoid cholesteatoma lesions,requiring the combined use of endoscope and microscope to perform endoscopic tympanoplasty and'Canal Wall Up'mastoidectomy;type Ⅳ,extensive involvement of mastoid cavity cholesteatoma lesions and/or cases with a potential risk of complications,removal of which can only be performed under a microscope for'Canal Wall Down'mastoidectomy.In addition,there were two special types:'difficult external auditory canal'and congenital cholesteatoma in children.In our system,type I and type U middle ear cholesteatoma surgery was completely performed under an endoscope alone.However,estimating the extent of the lesions,determining the choice of mastoid opening and reestablishing ventilation are the key points for an endoscopic approach to middle ear cholesteatoma.The classification of endoscopic middle ear cholesteatoma surgery may benefit the selection of surgical indications. | Yu SUN En-hao WANG Jin-tao YU Gang ZHONG Li-xin ZHU-Yi WANG Niu XUN Hong YU Wen ZHOU Zhen XIE Kun ZHANG Guo-run FAN Yi ZHONG Hong-jun XIAO Wei-jia KONG | 2020 | Current Medical Science2020，40，1： | 8 |
| 9 | Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience显示文摘The aim of the present study was to compare the relationship of morphologically defined non-bulging/herni-ated, bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient (ADC). Thirty-two healthy volunteers and 28 patients with back pain or sciatica were examined by MRI. All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades. The ADC values of nucleus pulposus (NP) were measured and recorded. The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs (P < 0.05), whereas there were no significant differences in ADC values between bulging and herniated discs (P > 0.05). Moreover, statistically significant relationship was found in the mean ADC values of NP between 'non-bulging/herniated and non-degenerated discs' and 'non-bulging/herniated degenerated discs' as well as herniated discs (P < 0.05). Linear regression analysis between ADC value and disc level revealed an inverse correlation (r = -0.18). The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities. | Gang Niu Xuewen Yu Jian Yang Rong Wang Shaojuan Zhang Youmin Guo | 2011 | The Journal of Biomedical Research2011，25，3： | 7 |
| 10 | Geochemical characteristics of Callovian-Oxfordian carbonates in Samandepe gas field,Amu Darya Basin,Turkmenistan显示文摘The Callovian-Oxfordian carbonate reservoirs are the most important hydrocarbon reservoir in the Samandepe gas field,Amu Darya basin,Turkmenistan.Based on the analysis of Fe,Mn and Sr trace elements,and carbon,oxygen and strontium isotopes,the genesis and evolutionary characteristics of the carbonate reservoirs were studied,and the conclusions were follows:1) Sustained transgressive-regressive cycles played an important role during Callovian-Oxfordian.The reservoir of reef-bank facies was well developed in the period of transgression,while the regional dense cap rocks developed in the period of regression;2) The 87 Sr/86 Sr ratio measured from rudist shells yields an age of 157.2 Ma according to the global strontium isotope curve;3) As diagenetic intensity increased,δ 13 C changed little,and δ 18 O showed strong negative deviation but was still limited to the range of Late Jurassic seawater.High Fe and Sr contents,and low Mn content,and the evolutionary trend of δ 13 C and δ 18 O all indicate that diagenesis occurred in a relatively confined environment,where the fluids were relatively reducing and contained hot brine.The stage of diagenesis reached is mesodiagenesis,which is very favorable for preservation of primary pores in carbonates;4) Strong dissolution of reef limestones,burial dolomitization and hydrothermal calcite precipitation were all the results of the interaction between the 87 Sr-rich diagenetic fluid and rocks;5) The analysis results of isotopes,fluid inclusions and vitrinite reflectance show that the diagenetic fluid was compaction-released water that originated from the deep,coal-bearing clastic strata. | Zheng Rongcai Li Yun Wu Lei Wu Xianzhong Li Fengjie Niu Gang | 2011 | Petroleum Science2011，8，4： | 6 |
| 11 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 12 | Coronary CT Angiography Using Low Iodine Delivery Rate and Tube Voltage Determined by Body Mass Index:Superiority in Clinical Practice显示文摘To explore the feasibility and superiority of iodine delivery rate(IDR)and tube voltage determined by patients'body mass index(BMI)in coronary CT angiography(CCTA),a total of 1567 patients undertaking CCTA during Feb.and Dec.2016 were enrolled and divided into two groups.In the control group,the IDR and tube voltage were fixed,while in the experimental group,the IDR and tube voltage were determined by patients,BMI.The volume of iodinated contrast media(ICM),extravasation rate,extravasation volume,extravasation recovery interval,incidence rate of adverse reactions,effective dose(ED)and image quality of the two groups were compared.The experiments demonstrated that the ICM volume,extravasation rate,extravasation volume,extravasation recovery interval,incidence of adverse reactions and ED were lower or shorter in the experimental group than in the control group,and the differences were statistically significant(all P<0.05).However,there were no significant differences in the mean CT value,image noise,signal to noise ratio and contrast to noise ratio between the two groups(all P<0.05),which were consistent with the diagnosticians*subjective evaluation outcomes.Our findings suggested that in CCTA,it is feasible to determine the IDR and tube voltage based on patients'BMI;low tube voltage and IDR are superior to the fixed tube voltage and IDR and are worthy of clinical promotion. | Wang YUAN Ting-ting QU Hui-juan WANG Mei-yu WANG Yuan QU Gang NIU Jian YANG | 2019 | Current Medical Science2019，39，5： | 4 |
| 13 | Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks显示文摘ObjectiveTo 探索在 XbaI 的多型性和 apolipoprotein B ( ApoB )的 MspI loci 之间的关系基因和 -75 bp , apolipoprotein AI ( ApoAI )基因的 +83 bp loci 和在 Xinjiang 的 Kazaks 的冠的心疾病( CHD ) Uyghur 自治区域, China.MethodsThese loci 被PCR限制碎片长度多型性( PCR-PFLP )分析。有 CHD 和二百和三十六控制的 205 个病人是 involved.ResultsThere 是在低密度的脂蛋白胆固醇( LDL-C )之中的重要区别, triglyceride ( TG )和在二之间的 ApoAI/ApoB 比率组织,但是在在二之间的四个地点的多型性频率之中的重要区别都不组织。X −−/Ms++/M1+−/M2++( 命名联盟 11 ) 的多型性联盟频率在与控制组相比的 CHD 是显著地更高的(14.6% 对 7.2% , P <0.05 ) 。在联盟 11 的全部的胆固醇(TC ) 的水平显著地更高,在联盟 11 的 ApoAI/ApoB 比率的水平比联盟 1 ∼ 显著地低; 10 在 CHD 病人。联盟 11 的 ApoAI/ApoB 比率的水平比联盟 1 ∼ 显著地低; 10 在控制组。联盟 3 的 ApoAI/ApoB 比率的层次分别地与在二个组的联盟 11 相比是显著地更高的。联盟 3 的 LDL-C 的水平比在在控制组的联盟 11 显著地低。联盟 5 的 TC 的水平比在 CHD 组的联盟 3 显著地高。联盟 5 的 ApoAI/ApoB 比率的水平比在联盟 3 或联盟 1 ∼ 显著地低;二中的 10 个分别地组织。联盟 5 的 LDL-C 的水平比在在控制组的联盟 3 显著地高。 ApoAI/ApoB 的比率是否定地与 TC 有关, LDL-C 并且断然与高级数据链路控制有关,两个都,在 CHD 和控制 groups.ConclusionCoalition , ApoB 和 ApoAI 基因的 4 loci 多型性中的 11 个在 Kazaks 与 CHD 被相关,并且也许 ApoAI/ApoB 的比率是在所有类脂化合物参数之中与 CHD 联系的最诊断的参数。CHD 可以也与联盟 5 被联系,并且,也许,联盟 3 可能对 CHD 作为一个保护因素被证实了,如果更多的样品被注册。 | Gang Huang Hua Zhong He-Man Re Hong-Wei Mao Qiang Niu Ye-Hong Chi | 2012 | Journal of Geriatric Cardiology2012，9，1： | 4 |
| 14 | Corrosion behavior of high-strength spring steel for high-speed railway显示文摘The corrosion resistance and evolution of corrosion products in medium-carbon high-strength spring steels were investigated in a neutral salt spray(5 wt% Na Cl solution). A formation model of γ-Fe OOH and a transformation model describing the conversion of γ-Fe OOH to α-Fe OOH were constructed. The results indicated that, at the initial corrosion stage, the corrosion resistance was gradually improved with the addition of Cr; however, with the addition of alloying element V, the corrosion resistance decreased. These results were attributed mainly to the initial corrosion stage being closely related to the matrix microstructure parameters such as grain-boundary character and dislocation density. After the rust layer was formed at a later corrosion stage, the corrosion resistance was reinforced with the addition of Cr and V because Cr strongly influenced the composition, structure, and morphology of the corrosion products. The results presented herein show that Cr was conducive to the transformation of γ-Fe OOH into α-Fe OOH. Moreover, V and Cr exhibited obvious synergy and were enriched in the inner layer of the corrosion products. | Gang Niu Yin-li Chen Hui-bin Wu Xuan Wang Di Tang | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，5： | 4 |
| 15 | Strong interface contact between NaYF_(4):Yb,Er and CdS promoting photocatalytic hydrogen evolution of NaYF_(4):Yb,Er/CdS composites显示文摘To acquire efficient photocatalysts,it is necessary to make effective use of visible light/Near Infrared(NIR)light,which takes up a large percentage of sunlight.Integrating upconversion materials with visible light active photocatalysts has attracted much attention in this regard.The interface contact between upcon-version material and photocatalyst has potential influence on the properties and thus the performance of the system.In this work,NaYF_(4):Yb,Er/CdS composites of the upconversion material NaYF_(4):Yb,Er nanorods and CdS nanoparticles were synthesized by ion adsorption/precipitation process and were then annealed in an argon atmosphere at different temperatures to modulate the microstructures.The annealing pro-cess endows the crystal transformation of cubic CdS with low crystallinity to hexagonal CdS with high crystallinity and,importantly,good interface contact between NaYF_(4):Yb,Er and CdS.Consequently,the hy-drogen evolution activity greatly increases from 171 to 2539μmol h^(−1) g^(−1) under the light irradiation ofλ>400 nm,and from 0 to 19μmol h^(−1) g^(−1) under the light irradiation ofλ>600 nm.This work might provide a useful reference for the rational design of promising photocatalyst involving upconversion ma-terials. | Huaze Zhu Yongqiang Yang Yuyang Kang Ping Niu Xiangdong Kang Zhiqing Yang Hengqiang Ye Gang Liu | 2022 | Journal of Materials Science & Technology2022，，7： | 3 |
| 16 | Genome-wide identification of target genes repressed by the zinc finger transcription factor REST/NRSF in the HEK 293 cell line显示文摘Transcriptional 压抑象在建立房间类型的 transcriptional 激活一样重要基因表示的特定的模式。沉默 RE1 抄写因素(休息) ,也作为 neuronal 知道限制 silencing 因素(NRSF ) ,是镇压的一个 transcriptional 管理者在 non-neuronal 房间或在由到特定的 DNA 的绑定的神经祖先房间的一组 neuronal 区别基因定序(抑压者 element-1/neuron-restrictive silencer 元素, RE1/NRSE ) 。然而,在 neuronal 发展的 REST/NRSF 功能几乎广泛地没被学习在各种各样的 non-neuronal 系对目标基因被知道可以导致房间区别。这里,我们使用技术与 microarray 策略相结合在人的 non-neuronal 房间线 HEK 293 识别潜在的 REST/NRSF 目标和 RE1/NRSEs 的 RNA 干扰(RNAi ) 。54 基因的表示根据 microarray 实验由在 HEK 293 房间的 REST/NRSF 的抑制是起来调整的, 13 那些被量的 RT-PCR 进一步证实。我们的结果证实电流的好信心和可靠性研究数据基于在 silico,在有 microarrays (薄片薄片) 的联合的染色质 immunoprecipitation,并且高产量的定序 ChIP-seq ) 。鉴于几千基因被证明了或预言了被 REST/NRSF 认识到的事实,然而,我们仅仅在那些之中的一些基因由和在基因的 RE1/NRSEs 地点的 REST/NRSF 的相互作用是直接起来调整的数据表演定序。 | Zhihui Liu Ming Liu Gang Niu Yi Cheng Jian Fei | 2009 | Acta Biochimica et Biophysica Sinica2009，41，12： | 3 |
| 17 | Efficacy of second-course intra-arterial chemotherapy in children for advanced retinoblastoma recurrence after intra-arterial chemotherapy显示文摘Purpose: The present study determined the efficacy and toxicity of second-course intra-arterial chemotherapy(IAC) in advanced retinoblastoma(RB) recurrence in children following failed initial IAC. Materials and Methods: A total of 24 child patients with unilateral or bilateral intra-ocular advanced RB(IIRC Group D and Group E) undergoing second-course IAC treatment after initial intra-arterial chemotherapy between September 2011 and November 2016 were enrolled. Global salvage, ocular adverse events, and systemic adverse events were assessed. Results: Following second-course IAC, 15(62.5%) showed complete control at 34 months follow-up, while 8 cases(33.3%) failed the treatment and 1 patient with metastatic disease(4.2%) eventually died of brain metastasis after refusing treatment. Ocular adverse events included eyelid edema(n=12), ptosis(n=5), forehead erythema(n-5), enophthalmos(n=3), and cataract(n=2). None of the patients had systemic adverse events, such as stroke or sepsis. Also, no secondary neoplasms and technical complications were observed. Conclusion: Second-course IAC is a potential alternative to enucleation in children with advanced RB, who fail an initial course of IAC. However, patients with advanced RB should be managed at experienced centers in order to consider all the alternatives before enucleation. | Hua Jiang Gang Shen Wenchan Xu Chuanqiang Niu Zhenyin Liu Jiejun Xia Jing Zhang | 2018 | Journal of Interventional Medicine2018，1，2： | 2 |
| 18 | Effect of the frequency of high-angle grain boundaries on the corrosion performance of 5wt%Cr steel in a CO2 aqueous environment显示文摘The corrosion behavior of 5 wt%Cr steel tempered at different temperatures was investigated by immersion testing and electrochemical testing in a CO_2 aqueous environment. When the tempering temperature exceeded 500℃, the corrosion rate increased. The corrosion layers consisted of Cr-rich compounds, which affected the corrosion behaviors of the steels immersed in the corrosive solution. The results of electrochemical experiments demonstrated that 5 wt%Cr steels with different microstructures exhibited pre-passivation characteristics that decreased their corrosion rate. Analysis by electron back-scattered diffraction showed that the frequency of high-angle grain boundaries(HAGBs) and the corrosion rate were well-correlated in specimens tempered at different temperatures. The corrosion rate increased with increasing HAGB frequency. | Hui-bin Wu Tao Wu Gang Niu Tao Li Rui-yan Sun Yang Gu | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，3： | 2 |
| 19 | Phylogenetic Analysis of the Dengue Virus Strains Causing the 2019 Dengue Fever Outbreak in Hainan,China显示文摘Dengue virus is an arthropod-borne pathogen that is transmitted to humans primarily by Aedes spp.mosquitos,causing the acute infectious disease,dengue fever(DF).Until 2019,no dengue outbreak had been reported in Hainan Province for over 20 years.However,in early September of 2019,an increasing number of infected cases appeared and the DF outbreak lasted for over one month in Haikou City,Hainan Province.In our study,we collected 97 plasma samples from DF patients at three hospitals,as well as 1585 mosquito larvae samples from puddles in different areas of Haikou.There were 49(50.5%)plasma samples found to be strongly positive and 9(9.3%)plasma samples were weakly positive against the NS1 antigen.We discovered DENV both in the patient's plasma samples and mosquito larvae samples,and isolated the virus from C6/36 cells inoculated with the acute phase serum of patients.Phylogenetic analysis revealed that the new strains were the most closely related to the epidemic strain in the southern regions of China,belonging to lineageⅣ,genotypeⅠ,DENV-1.Compared to the seven closest strains from neighboring countries and provinces,a total of 18 amino acid mutations occurred in the coding sequences(CDS)of the new isolated strain,DENV1 HMU-HKU-2.Our data shows that dengue virus is re-emerged in Hainan,and pose new threats for public health.Thus regular molecular epidemiological surveillance is necessary for control and prevention of DENV transmission. | Jiang Du Liyuan Zhang Xiaoyuan Hu Ruoyan Peng Gaoyu Wang Yi Huang Wenqi Wang Kunliang Wu Qiang Wang Haoxiang Su Fan Yang Yun Zhang Chuanning Tang Xiuji Cui Lina Niu Gang Lu Meifang Xiao Yongguo Du Feifei Yin | 2021 | Virologica Sinica2021，36，4： | 2 |
| 20 | Preparation of Au NPs/ZnO NTs Hybrid Array and Its Photo Catalytic Performance for MO显示文摘X-ray diffraction, scanning electron microscopy and transmission electron microscopy were employed to investigate the microstructure and morphology of Au NPs/ZnO NTs, and their photo-catalytic capability was assessed to a nicety. The results demonstrated that the diameter and the wall thickness of ZnO nanotube were about 200 and 50 nm, respectively. The diameter of Au nanoparticle was about 30 nm. The characterization on the photo-catalytic capability of the Au-ZnO nanotube hybrid indicated that the degradation of methyl orange was 80% within 4 h. Controlled experiments have shown that Au-Zn O nanotube hybrid presents superior photo-catalytic capability to both bare ZnO nanorod and Au-ZnO nanorod hybrid indicated that the degradation procedure of methyl orange. | 曾天 WEI Jin LIU Lin DENG Jiatao ZHENG Gang ZHANG Pei NIU Tongjun JIAO Zhifeng JIN Yong 孙小松 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，3： | 2 |
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