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| 1 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 2 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 3 | A Statistics Overview of Ship Recycling显示文摘 | Nikos E M | 2007 | IMO NEWS2007，，04： | 1 |
| 4 | Novel cytotoxic brominated diterpenes from the red alga Laurencia obtusa 显示文摘 | Dimitra I Nikos M Const antinos V | 2003 | Journal of Organic Chemistry2003，68，20： | 1 |
| 5 | Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches 显示文摘 | Heidi K Hugo G Niko M | 2006 | Experim Cell Res2006，319，6： | 1 |
| 6 | Pushing the limits of energetic materials the synthesis and charac- terization of dihydroxylammonium 5,5 -bistetrazole-1, l'-diolate显示文摘 | Niko Fischer Dennis Fischer Thomas M | 2012 | Journal of Materials Chemistry2012，，20： | 1 |
| 7 | Mutlifunctional ATRP initiators:Synthesis of four-arm star homopolymers of methyl methacrylate and graft copolymers of polystyrene and poly(t-butyl methacrylate)显示文摘 | Polyxeni M Stergios P Nikos H | 2001 | J Polym Sci Part A:Polym Chem2001，39，： | 1 |
| 8 | An efficient and scalable algorithm for clustering XML documents by structure显示文摘 | WANG Lian DAVID Wai-lok Cheung NIKOS M | 2004 | IEEE Trans on Knowledge and Data Engineering2004，16，1： | 1 |
| 9 | 3D computer-aided recon- struction of the morphology of teeth with malformations显示文摘 | Kleoniki L Georgios M Nikos N | 1997 | Stud Health Technol Inform1997，43，： | 1 |
| 10 | Microgrids显示文摘 | Nikos H Hiroshi A Chris M I R | 2007 | IEEE Power and Energy Magazine2007，5，4： | 1 |
| 11 | Calculation and Stability Investigation of Periodic Steady States of the Voltage Converter Buck DC-DC Converter显示文摘 | GEORGIOS A P NIKOS I M | 2004 | IEEE Transactions on Power Electronics2004，19，7： | 1 |
| 12 | Mutlifunctional ATRP initiators:Synthesis of four-arm star homopolymers of methyl methacrylate and graft copolymers of polystyrene and poly(t-butyl methacrylate) 显示文摘 | Polyxeni M Stergios P Nikos H | 2001 | J Polym Sci Polym Chem2001，39，5： | 1 |
| 13 | Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma显示文摘 | Jarkko T. Korpi Jaana Hagstr?m Niko Lehtonen Jyrki Parkkinen Timo Sorsa Tuula Salo Minna Laitinen | 2010 | Surgical Oncology2010，，1： | 1 |
| 14 | Calculation and stability investigation of periodic steady states of the voltage converter buck DC-DC converter显示文摘 | Georegios A P Nikos I M | 2004 | IEEE Transaction on Power Electronics2004，19，7： | 1 |
| 15 | Disease and community structure : the importance of host self-regulation in a host-hostpathogen model 显示文摘 | Begon M Bowers R G Nikos K | 1992 | Am Nat1992，139，6： | 1 |
| 16 | Synthesis and dharacteriza- tion of Ti3AIC2 显示文摘 | Niko|ay Tzenov V Barsoum M W | 2000 | J Am Ceram Soc2000，83，4： | 1 |
| 17 | Novel cytotoxic brominated diterpenes from the red algaLaurencia obtusa显示文摘 | DIMITRA I NIKOS M CONSTANTINOS V et a1 | 2003 | Journal of Organic Chemistry2003，68，20： | 1 |
| 18 | Intramedullary and spinal canal tumors in patients with neurofibromatosis 2:MR imaging findings and correlation with genotypel 显示文摘 | Nicholas JPA Nikos CO Christina M Br | 2001 | Radiology2001，218，10： | 1 |
| 19 | Multi-agent systems for power engi- neering applications-Part I : concepts, approaches, and technical challenges 显示文摘 | Stephen D J McArthur Victoria M Catterson Nikos D Hatziargyriou | 2007 | IEEE Transactions on Power Systems2007，22，4： | 1 |
| 20 | Multi-agent systems for power engi- neering applications - Part II : technologies, standards, and tools for building multi-agent systems 显示文摘 | Stephen D J MeArthur Victoria M Catterson Nikos D Hatziargyriou | 2007 | IEEE Transactions on Power Systems2007，22，4： | 1 |
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