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| 1 | Bowel cleansing before colonoscopy:Balancing efficacy,safety,cost and patient tolerance显示文摘Effective colorectal cancer screening relies on reliable colonoscopy findings which are themselves dependent on adequate bowel cleansing. Research has consistently demonstrated that inadequate bowel preparation adversely affects the adenoma detection rate and leads gastroenterologists to recommend earlier follow up than is consistent with published guidelines. Poor preparation affects as many as 30% of colonoscopies and contributes to an increased cost of colonoscopies. Patient tolerability is strongly affected by the preparation chosen and manner in which it is administered. Poor tolerability is,in turn,associated with lower quality bowel preparations. Recently,several new developments in both agents being used for bowel preparation and in the timing of administration have brought endoscopists closer to achieving the goal of effective,reliable,safe,and tolerable regimens. Historically,large volume preparations given in a single dose were administered to patients in order to achieve adequate bowel cleansing. These were poorly tolerated,and the unpleasant taste of and significant side effects produced by these large volume regimens contributed significantly to patients' inability to reliably complete the preparation and to a reluctance to repeat the procedure. Smaller volumes,including preparations that are administered as tablets to be consumed with water,given as split doses have significantly improved both the patient experience and efficacy,and an appreciation of the importance of the preparation to colonoscopy interval have produced additional cleansing. | Nicole M Harrison Michael C Hjelkrem | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，1： | 19 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | Silent synapses during development of thalamocortical input 显示文摘 | CRAIR M C NICOLL R A | 1997 | Neuron1997，18，： | 1 |
| 4 | Structural features of prolactins and growth hormones that can be related to their biological properties显示文摘 | Nicoll C S Mayer G L Russell S M | 1986 | Endocr Rev1986，7，： | 1 |
| 5 | Oxidant stress, im mune dysregulation, and vascular function in type I diabetes显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 6 | Application of nanoscale zero valent iron (NZVI) for groundwater remediation in Europe 显示文摘 | Nicole C M Jurgen B Johannes B | 2012 | Environmental Science Pollution Research2012，19，2： | 1 |
| 7 | Ancient signals: comparative genomics of plant MAPK and MAPKK gene families 显示文摘 | Hamel L P Nicole M C Sritubtim S | 2006 | Trends Plant Sci2006，11，4： | 1 |
| 8 | Using field measurements of desktop illuminance in European offices to investigate its dependence on outdoor conditions and its effect on occupant satisfaction, and the use of lights and blinds 显示文摘 | Nicol F Wilson M Chiancarella C | 2006 | Energy andBuildings2006，38，： | 1 |
| 9 | The importance of the ni- trous oxide pathway to NOx in lean-premixed combustion显示文摘 | Nicol D G Steele R C Marinov N M | 1995 | Journal of Engineering for Gas Turbine and Power1995，117，： | 1 |
| 10 | Saturation of wave-packet interferences:direct observation of spin precession in potassium atoms显示文摘 | NICOLE C BOUCHENE M A ZAMITH S | 1999 | Physical Review1999，60，3： | 1 |
| 11 | Combind effects of heat stess,dehydration and exercise on neuromuscular function in human显示文摘 | Ftaiti F Grelot L Coundreuse J M Nicol C | 2002 | Eur J Appl Physiol2002，84，： | 1 |
| 12 | Risk factors for dental caries in young children显示文摘 | HARRIS R NICOLL A D PINE C M | 2004 | A systematic review of the literature2004，21，1： | 1 |
| 13 | Kinetics of the dissolution of il-menite in sulfuric acid solutions under reducing conditions 显示文摘 | ZHANG S C NICOL M J | 2010 | Hydrometallurgy2010，103，： | 1 |
| 14 | OXidant stress, immunedysregulation, and vascular function in type I diabetes 显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2011 | AntioXid RedoX Signal2011，9，7： | 1 |
| 15 | Real-time prediction of hand trajectory by ensemblesof cortical neurons in primates显示文摘 | Wessberg J Stambaugh C R Kralik J D Beck P D Laubach M Chapin J K Kim J Biggs J Srinivasan M A Nicolelis M A L | 2000 | Nature2000，408，： | 1 |
| 16 | TIGER: Real-time situation assessnent of dynamic systems 显示文摘 | Milne R Nicol C Ghallab M | 1994 | Intelligent Systems Engineering1994，3，3： | 1 |
| 17 | Antibody–drug conjugates: targeted drug delivery for cancer显示文摘 | Stephen C Alley Nicole M Okeley Peter D Senter | 2010 | Current Opinion in Chemical Biology2010，，4： | 1 |
| 18 | Photo- ionization microscopy 显示文摘 | Nicole C Offerhaus H L Vrakking M J J | 2002 | Physical Review Letters2002，88，13： | 1 |
| 19 | Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer 显示文摘 | JOANA C NICOLE C V PATRICIA M | 2012 | J Pathol2012，22，8： | 1 |
| 20 | Soils,a sink for N2O?A review显示文摘 | Lydie C Nicole W Aurelie M | 2007 | Global Change Biology2007，13，1： | 1 |
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