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| 1 | Clinical applications, limitations and future role of transient elastography in the management of liver disease显示文摘Transient elastography(TE) is a reliable tool for the non-invasive assessment of liver fibrosis in routine clinical practice. TE is currently approved for use in Europe, Asia and the United States. The widespread adoption of this technology is certain to increase the use of TE worldwide. Although TE has been well validated in chronic viral hepatitis, its clinical role in other liver diseases remains less clear. The advent of new treatment for chronic hepatitis C and emerging prevalence of non-alcoholic steatohepatitis raises new questions on the role of TE in current clinical practice. This review aims to examine the clinical applications, limitations and future role of TE in current clinical practice in light of the changing epidemiology of liver diseases and new clinical management paradigms. In current clinical practice, TE is the most accurate noninvasive method for diagnosis of liver cirrhosis. TE is useful to rule out fibrosis and cirrhosis but does not have sufficient accuracy to discern between various stages of fibrosis. The clinical role of TE has evolved from cross-sectional point-in-time assessment of fibrosis and cirrhosis to the more relevant role of prediction of vital clinical end-points. This provides clinicians with the ability to modify treatment strategies based on the information provided by TE. TE has evolved over the past decade to become an essential tool to assist the clinician in the management of chronic liver disease. | Pik Eu Chang George Boon-Bee Goh Jing Hieng Ngu Hiang Keat Tan Chee Kiat Tan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 5 |
| 2 | Systematic review with meta‐analysis: non‐invasive assessment of non‐alcoholic fatty liver disease – the role of transient elastography and plasma cytokeratin‐18 fragments显示文摘 | R. Kwok Y.‐K. Tse G. L.‐H. Wong Y. Ha A. U. Lee M. C. Ngu H. L.‐Y. Chan V. W.‐S. Wong | 2014 | Aliment Pharmacol Ther2014，，3： | 4 |
| 3 | 废米糠制备炭纳米颗粒及其对金属离子的光学传感性能(英文)显示文摘以废米糠为原料,浓硫酸为脱水剂,通过炭化法制备出炭纳米颗粒(CNPs),探讨CNPs荧光发射特征、金属离子的淬灭效应以及作为Sn(II)离子传感材料应用。CNPs产率最佳条件为:硫酸浓度12 mol/L、加热温度120℃及恒温时间30 min。样品在水中强蓝光的最大发射波为439 nm。通过加入金属离子,使金属离子与CNPs表面间形成复合物而淬灭荧光。Sn(II)离子对CNPs荧光具有显著的淬灭效应。Sn(II)离子浓度对淬灭效应符合Stern-Volmer线性关系,Sn(II)离子为6.13 mmol/L。Sn(II)离子的检测限为18.7μmol/L。 | Peggy Zhen Zhen Ngu Stephanie Pei Phing Chia Jessica Fung Yee Fong Sing Muk Ng | 2016 | 新型炭材料2016，31，2： | 4 |
| 4 | Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome:A prospective multi-centre cohort study显示文摘BACKGROUND Autoimmune markers including plasma cells(PC),anti-smooth-muscle antibody(ASMA),anti-nuclear antibody(ANA),and raised immunoglobulin G(IgG)are commonly observed in non-alcoholic steatohepatitis(NASH),however their clinical significance is unknown.AIM To determine if autoimmune markers in NASH patients are independently associated with poorer clinical outcomes.METHODS Consecutive patients with biopsy proven NASH from Christchurch Hospital,New Zealand and Singapore General Hospital(SGH)were included between 2005 to 2016 in a prospective multi-centre cohort study.Patients with other causes of chronic liver disease were excluded.IgG>14 g/L or globulin fraction>50%,ANA≥1:40,SMA≥1:40 were considered positive.Multivariate analysis was performed to assess which markers were independently associated with mortality and hepatic decompensation.RESULTS Total 261 patients were included of which 201 were from SGH.The median age was 53 and 51.9%were male.Advanced fibrosis was present in 31.4%at diagnosis.PC,ASMA,ANA and raised IgG were observed in 13.1%,4.9%,27.8%and 30.1%of patients respectively.After multivariate analysis,elevated IgG[Hazard Ratio(HR)6.79,95%CI:2.93-17.15]and fibrosis stage(HR 1.37,95%CI:1.03-1.87)were found to be independently associated with increased risk of liver decompensation.Age(HR 1.06,95%CI:1.02-1.10)and elevated IgG(HR 3.79,95%CI:1.90-7.68)were independent factors associated with higher mortality risk.CONCLUSION Elevated IgG,rather than ANA,ASMA or plasma cells,is independently associated with increased risk of hepatic decompensation and mortality in NASH.It could hence be important for prognostication. | Marianne Anastasia De Roza Mehul Lamba George Boon-Bee Goh Johnathan Huey-Ming Lum Mark Chang-Chuen Cheah Jing Hieng Jeffrey Ngu | 2021 | World Journal of Gastroenterology2021，27，43： | 2 |
| 5 | Acute-on-chronic liver failure: Controversies and consensus显示文摘Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver disease.Consequences include high short-term morbidity,mortality,and healthcare resource utilisation.ACLF encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ failures.Common precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease burden.Liver transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care unit.This review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps. | Natalie L Y Ngu Eliza Flanagan Sally Bell Suong T Le | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 6 | Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry显示文摘 | Jingyu Diao Homer Pantua Hai Ngu Laszlo Komuves Lauri Diehl Gabriele Schaefer Sharookh B. Kapadia | 2012 | Journal of Virology2012，，20： | 2 |
| 7 | The application of extended modified Lambert Beer model for measurement of blood carboxyhemoglobin and oxyhemoglobin saturation显示文摘This work presents the use of extended Modified Lambert Beer(MLB)model for accurate andcontinuous monitoring of percent blood carboxyhemoglobin(COHb)(SCO)and oxyhemoglobin(OxyHb)saturation(SO,)via a fitting procedure.This quantification technique is based on theabsorption characteristics of hemoglobin derivatives in the wavelength range of 520-600 nm togive the best estimates of the required parameters.A comparison of the performance of the developed model and MILB law is made using attenuation data from Monte Carlo simulations for a two-layered skin model.The results revealed a lower mean absolute error of 0.4%in the valuesestimated by the developed model as compared to 10%that is given by the MILB law.This studyshowed that the discussed approach is able to provide consistent and accurate measurement ofblood SO,and SCO across diferent skin pigmen tations suggesting that it may potentially be usedas an alternative means for clinical diagnosis of carbon monoxide(CO)poisoning. | Audrey Huong Xavier Ngu | 2014 | Journal of Innovative Optical Health Sciences2014，7，3： | 2 |
| 8 | QoS-aware middleware for Web services composition显示文摘 | Zeng L Z Benatallah B Ngu A H H | 2004 | IEEE Transactions on Software Englneering2004，30，5： | 1 |
| 9 | QoS-aware middleware for Web services composition显示文摘 | ZENG L Z BENATALLSH B NGU A H H | 2004 | IEEE Transactions on Software Engineering2004，30，5： | 1 |
| 10 | QoS-aware middleware for web services composition 显示文摘 | Zeng L Z Benatallah B Ngu A HH | 2004 | IEEE Transactions on SoftwareEngineering2004，30，5： | 1 |
| 11 | QoS-aware middleware for Web services composition显示文摘 | Zeng L Z Benatallah B Ngu A H H | 2004 | IEEE Trans on Software Engineering2004，30，5： | 1 |
| 12 | Predictors of poor outcome in patients w ith autoimmune hepatitis: A population‐based study显示文摘 | Jing Hieng Ngu Richard Blair Gearry Chris Miles Frampton Catherine A.M. Stedman | 2013 | Hepatology2013，，： | 1 |
| 13 | Sitehelper: A localized agent that helps incremental exploration of the world wide web显示文摘 | Weng Ngu D S Wu X | 1997 | Computer Networks and ISDN Systems1997，29，12： | 1 |
| 14 | QoS-aware middleware for Web services composition 显示文摘 | Zeng Liangzhao Benatallah B Ngu A H H | 2004 | IEEE transac- tions on software engineering2004，30，5： | 1 |
| 15 | QoS-aware middle- ware for Web services composition显示文摘 | Zeng L Benatallah B Ngu A H H | 2004 | IEEE Transactions on Software Engineering2004，30，5： | 1 |
| 16 | Unusual presentation of granulocytic sarcoma in the breast:a case report and review of the literature显示文摘 | Ngu IW Sinclair EC Greenaway S | 2001 | Diagn Cytopathol2001，24，1： | 1 |
| 17 | QoS-aware Middleware for Web Services Composition显示文摘 | Zeng Liangzhao Benatallah B Ngu A H H | 2004 | IEEE Transactions on Software Engineering2004，30，5： | 1 |
| 18 | 冬虫夏草醇提物对T淋巴细胞亚群的影响显示文摘 | 陈国桢 陈国林 汤清明 Tsieh sun Jelly shai Joan Henshall Mai Ngu | 1987 | 湖南医学院学报1987，，04： | 1 |
| 19 | Hypophosphataemic osteomalacia in patients on adefovir dipivoxil显示文摘 | GIRGIS CM WONG T NGU MC | 2011 | J Clin Gastro- enterol2011，45，5： | 1 |
| 20 | Development of the extrinsic sympathetic innervation to the enteric neurones of the rat small intestine 显示文摘 | Hill C E Ngu M C | 1987 | J Auton Nerv Syst1987，19，2： | 1 |
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