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| 1 | Rabeprazole vs esomeprazole in non-erosive gastro-esophageal reflux disease: A randomized, double-blind study in urban Asia显示文摘AIM:Gastro-esophageal reflux disease (GERD) is becoming increasingly common in Asia. Data on the efficacy of proton pump inhibitors in patients with non-erosive GERD (NERD)in Asia is lacking. This double-blind study compared the efficacy and safety of rabeprazole with esomeprazole in relief of symptoms in patients with NERD.METHODS: One hundred and thirty-four patients with reflux symptoms of NERD and normal endoscopy were randomized to receive rabeprazole 10 mg or esomeprazole 20 mg once daily for 4 wk. Symptoms were recorded in a diary and changes in severity of symptoms noted.RESULTS: At 4 wk of treatment, rabeprazole 10 mg and esomeprazole 20 mg were comparable with regards to the primary endpoint of time to achieve 24-h symptomfree interval for heartburn 8.5 d vs9 d and regurgitation 6 d vs 7.5 d. Rabeprazole and esomeprazole were also similarly efficacious in term of patient's global evaluation with 96% of patients on rabeprazole and 87.9% of patients on esomeprazole, reporting that symptoms improved(P=NS). Satisfactory relief of day- and night-time symptoms was achieved in 98% of patients receiving rabeprazole and 81.4% of patients receiving esomeprazole. Adverse events were comparable in both groups (P = NS).CONCLUSION: Rabeprazole 10 mg has a similar efficacy and safety profile in Asians with NERD as esomeprazole 20 mg. Further study is necessary to investigate whether the small differences between the two drugs seen in this study are related to the improved pharmacodynamicpro perties of rabeprazole. Both drugs were well tolerated. | KM Fock EK Teo TL Ang TS Chua TM Ng YL Tan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 2 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 3 | Renal vasodilatory action of dopamine in patients with heart failure:magnitude of effect and site of action显示文摘 | Elkayam U Ng TM Hatamizadeh P | | 0，，02： | 1 |
| 4 | Metronidazole-resistant Helicobacter pylori in an urban Asian population 显示文摘 | Teo EK Fock KM Ng TM | 2000 | J Gastroenterol Hepatol2000，15，5： | 1 |
| 5 | A randomized clinical trial comparing open to arthroscopic acromioplasty with mini-open rotator cuff repair for fullthickness rotator cuff tears:disease-specific quality of Life outcome at an average 2-year follow-up显示文摘 | Mohtadi NG Hollinshead RM Sasyniuk TM | | 0，，06： | 1 |
| 6 | Video-assisted thoracic surgery for primary spontaneous hemopneumothorax 显示文摘 | Hwong TM Ng CS Lee TW | 2004 | Eur J Cardiothorac Surg2004，26，5： | 1 |
| 7 | Levosimendan, a new calcium-sensitizing inotrope for heart failure 显示文摘 | Ng TM | 2004 | Pharmacotherapy2004，24，10： | 1 |
| 8 | Systemic lupus erythematosus with concurrent protein-losing enteropathy and primary sclerosing cholangitis:a unique association显示文摘 | OH DC NG TM HO J | 2006 | Lupus2006，15，2： | 1 |
| 9 | Catheter fragmentation of massive pulmonary embolus:guidance with-transesophageal echocardiography显示文摘 | Chou TM Smdira NG | 1995 | Am Heart J1995，130，： | 1 |
| 10 | Gastric cacer and H·Pylori infection in Singapore: Lack of association with CagA status 显示文摘 | Ng TM Fock KM Khim MM | 1997 | Gut1997，，： | 1 |
| 11 | Prophylactic ilioinguinalneurectomy in open inguinal hernia repair:a double-blind rand-omized controlled trial显示文摘 | Mui WL Ng CS Fung TM | 2006 | Ann Surg2006，244，1： | 1 |
| 12 | Levosimendan,a new calcium sensitizing inotropoe for heart failure显示文摘 | NG TM | 2004 | Pharmacotherapy2004，24，10： | 1 |
| 13 | Is hepatic resection for largeor multinodular hepatocellular carcinoma justified? Results from amulti-institutional database 显示文摘 | Ng KK Vauthey JN Pawlik TM | 2005 | Ann Surg Oncol2005，12，5： | 1 |
| 14 | Renal vasodilatory action of dopamine in patients with heart failure:magnitude of effect and site of action显示文摘 | Elkayam U Ng TM Hatamizadeh P | 2008 | Circulation2008，117，2： | 1 |
| 15 | Levosimendan,a new calcium-sensitizing inotropoe for heart failure显示文摘 | NG TM | 2004 | Pharmacotherapy2004，24，10： | 1 |
| 16 | A previously undescribed coronavirus associated with respiratory disease in humans 显示文摘 | Fouchier RA Hartwig NG Bestebroer TM | 2004 | Proc Natl Acad Sci2004，101，16： | 1 |
| 17 | Prophylactic ilioinguinal neurectomy in open inguinal hernia repair: a double-blind random- ized controlled trial显示文摘 | Mui WL Ng CS Fung TM | 2006 | Ann Snrg2006，244，1： | 1 |
| 18 | Predicting gains in dementia caregiving 显示文摘 | LIEW TM LUO N NG WY | 2010 | Dement Geriatr Cogn Disord2010，29，2： | 1 |
| 19 | Arthroscopic versus open repair for traumatic anterior shoulder instability:a meta-analysis显示文摘 | Mohtadi NG Bitar IJ Sasyniuk TM | 2005 | Arthroscopy2005，21，： | 1 |
| 20 | Comparison of bumetanide and metolazone-based diuretic regimens to furosemide in acute heart failure显示文摘 | Ng TM Konopka E Hyderi AF | 2013 | J Cardiovase Pharmacol Ther2013，18，4： | 1 |
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