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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Does preoperative atrial fibrillation portend a poorer prognosis in patients undergoing isolated aortic valve replacement- A multicentre Australian study显示文摘 | Saxena A Dinh D T Reid C M Smith J A Shardey G C Newcomb A E | 2013 | Can J Cardiol2013，29，： | 1 |
| 3 | Guidelines for power and time variables for microwave ablation in an in vivo porcine kidney显示文摘 | Hope W W Schmelzer T M Newcomb W L | 2009 | J Surg Res2009，153，2： | 1 |
| 4 | The effects of sexual partnership and relationship characteristics on three sexual risk variables in young men who have sex with men显示文摘 | Newcomb M E Ryan D T Garofalo R | 2014 | Archives of Sexual Behavior2014，43，1： | 1 |
| 5 | The impact of college on students 显示文摘 | FELDMAN K A NEWCOMB T M | 1969 | San Francisco: Jossey-Bass1969，，： | 1 |
| 6 | Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas 显示文摘 | Newcomb EW Alonso M Sung T | 2000 | Hum Pathol2000，31，： | 1 |
| 7 | Thermal effects and pressure distributions in brakes 显示文摘 | Day A J Tirovic M Newcomb T P | 1991 | Journal of Automo- bile Engineering1991，205，3： | 1 |
| 8 | The association of body size and large bowel cancer risk in Wisconsin(United States)women显示文摘 | Dietz A T Newcomb P A Marcus P M | 1995 | Cancer Causes Control1995，6，4： | 1 |
| 9 | Detailed analysis of mechanical properties ofSeBiLOYs I and II 显示文摘 | WHITING L V SAHOO M NEWCOMBE P D ZAVADIL R PETERS D T | 1999 | AFS Transactions1999，182，： | 1 |
| 10 | Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol显示文摘 | Newcomb EW Lymberis SC Lukyanov Y Shao Y Schnee T Devitt M | 2006 | Cell Cycle2006，5，1： | 1 |
| 11 | Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy 显示文摘 | Black M E Newcomb T G Wilson H M | 1996 | Proc Natl Acad Sci USA1996，93，8： | 1 |
| 12 | Incidence of p14gene deletion in highgrade adault and pediatric astrocytomas显示文摘 | Newcomb EW Alonso M Sung T | 2000 | Hum Pathol(Jap)2000，31，1： | 1 |
| 13 | Thermal effects and pressure distributions in brakes显示文摘 | Tirovic M Newcomb T P | 1991 | Engrs-PartD:Journal of Automobile Engineering1991，205，： | 1 |
| 14 | Comparison of blood vessel sealing among new electrosurgi- cal and ultrasonic devices 显示文摘 | NEWCOMB W L HOPE W W SCI-IMEIZER T M | 2009 | Surgical Endoscopy and Other Interventional Techniques2009，23，1： | 1 |
| 15 | RNA interference in the light brown apple moth,Epiphyas postvittana (Walker) induced by double-stranded RNA feeding显示文摘 | Turner C T Davy M W MacDiarmid R M Plummer K M Birch N P and Newcomb R D | | 0，，： | 1 |
| 16 | Thermal effects and pressure distributions in brakes 显示文摘 | Day A J Tirovic M Newcomb T P | 1991 | Proceedings of the Institution of Mechanical Engineers Part D: Journal of Automobile Engineering1991，205，3： | 1 |
| 17 | An Approach to the Study of Communicative Acts 显示文摘 | NEWCOMB T M | 1953 | Psychological Review1953，60，1： | 1 |
| 18 | The Prediction of Interpersonal Attraction显示文摘 | Newcomb T M | 1956 | American Psychologist1956，11，： | 1 |
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