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| 1 | Impact of environmental and dietary factors on the course of inflammatory bowel disease显示文摘Besides their possible effects on the development of inflammatory bowel disease(IBD),some environmental factors can modulate the clinical course of both ulcerative colitis(UC) and Crohn's disease(CD).This review is mainly devoted to describing the current knowledge of the impact of some of these factors on the outcome of IBD,with special emphasis on smoking and diet.Although the impact of smoking on the susceptibility to develop CD and UC is firmly established,its influence on the clinical course of both diseases is still debatable.In CD,active smoking is a risk factor for postoperative recurrence.Beyond this clinical setting,smoking cessation seems to be advantageous in those CD patients who were smokers at disease diagnosis,while smoking resumption may be of benefit in ex-smokers with resistant UC.The role of dietary habits on the development of IBD is far from being well established.Also,food intolerances are very frequent,but usually inconsistent among IBD patients,and therefore no general dietary recommendations can be made in these patients.In general,IBD patients should eat a diet as varied as possible.Regarding the possible therapeutic role of some dietary components in IBD,lessons should be drawn from the investigation of the primary therapeutic effect of enteral nutrition in CD.Low-fat diets seem to be particularly useful.Also,some lipid sources,such as olive oil,medium-chain triglycerides,and perhaps omega-3 fatty acids,might have a therapeutic effect.Fermentable fiber may have a role in preventing relapses in inactive UC. | Eduard Cabré Eugeni Domènech | 2012 | World Journal of Gastroenterology2012，18，29： | 15 |
| 2 | Management of Crohn’s disease in smokers:Is an alternative approach necessary?显示文摘Inflammatory bowel disease(IBD) is a chronic condition with a pathogenic background that involves both genetic and environmental factors.Although important progress has been made regarding the former in the last decade,scarce knowledge is available for the latter.In this sense,smoking remains the most important environmental factor in IBD.Active smoking increases the risk of developing Crohn's disease(CD).Moreover,CD patients who start or continue smoking after disease diagnosis are at risk for poorer outcomes such as higher therapeutic requirements and disease-related complications,as compared to those patients who quit smoking or who never smoked.However,the harmful effect of active smoking is not uniform in all patients or in all clinical scenarios.Interventions designed to facilitate smoking cessation may impact the course of the disease.In this article,the available evidence of the deleterious effects of smoking on CD is reviewed in detail,and alternative therapeutic approaches to CD in smokers are proposed. | Pilar Nos Eugeni Domènech | 2011 | World Journal of Gastroenterology2011，17，31： | 6 |
| 3 | European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease显示文摘 | J.F. Rahier S. Ben-Horin Y. Chowers C. Conlon P. De Munter G. D’Haens E. Domènech R. Eliakim A. Eser J. Frater M. Gassull M. Giladi A. Kaser M. Lémann T. Moreels A. Moschen R. Pollok W. Reinisch M. Schunter E.F. Stange H. Tilg G. Van Assche N. Viget B. Vu | 2009 | Journal of Crohn’s and Colitis2009，，2： | 3 |
| 4 | Use of granulocyte/monocytapheresis in ulcerative colitis:A practical review from a European perspective显示文摘Half of the patients with ulcerative colitis require at least one course of systemic corticosteroids in their lifetime.Approximately 75%of these patients will also require immunosuppressive drugs(i.e.,thiopurines or biological agents)in the mid-term to avoid colectomy.Immunosuppressive drugs raise some concerns due to an increased risk of serious and opportunistic infections and cancer,particularly in elderly and co-morbid patients,underlining the unmet need for safer alternative therapies.Granulocyte/monocytapheresis(GMA),a CE-marked,non-pharmacological procedure for the treatment of ulcerative colitis(among other immune-mediated diseases),remains the only therapy targeting neutrophils,the hallmark of pathology in ulcerative colitis.GMA has proven its efficacy in different clinical scenarios and shows an excellent and unique safety profile.In spite of being a first line therapy in Japan,GMA use is still limited to a small number of centres and countries in Europe.In this article,we aim to give an overview from a European perspective of the mechanism of action,recent clinical data on efficacy and practical aspects for the use of GMA in ulcerative colitis. | Eugeni Domènech Joan-Ramon Grífols Ayesha Akbar Axel U Dignass | 2021 | World Journal of Gastroenterology2021，27，10： | 2 |
| 5 | Impact of Periampullary Duodenal Diverticula at Endoscopic Retrograde Cholangiopancreatography: A Proposed Classification of Periampullary Duodenal Diverticula显示文摘 | Jaume Boix Vicente Lorenzo-Zú?iga Fidel A?a?os Eugeni Domènech Rosa M. Morillas Miguel A. Gassull | 2006 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2006，，4： | 2 |
| 6 | Enabling Technology for Knowledge Sharing显示文摘 | R Neches R Fikes T Finin | 1991 | AI Magazine1991，12，3： | 2 |
| 7 | Impact of Capsule Endoscopy Findings in the Management of Crohn’s Disease显示文摘 | Vicente Lorenzo-Zú?iga Vicente Moreno Vega Eugeni Domènech Eduard Cabré Míriam Ma?osa Jaume Boix | 2010 | Digestive Diseases and Sciences2010，，2： | 2 |
| 8 | Enabling Technology Knowledge Sharing显示文摘 | Neches R Fikes R E Gruber T R | 1991 | AI Magazine1991，12，3： | 1 |
| 9 | Functional Dio geography of ocean microbes revealed through non-negative matrix factorization显示文摘 | Jiang X Langille M G Neches R Y | 2012 | PLoS One2012，7，43： | 1 |
| 10 | TheCaMV?35S promoter is highly active on floral organs and pollen of transgenic strawberry plants显示文摘 | M. Cordero Mesa N. Santiago-Doménech F. Pliego-Alfaro M. A. Quesada J. A. Mercado | 2004 | Plant Cell Reports (-)2004，，1： | 1 |
| 11 | Motor cortical hyperexcitability in idiopathic scoliosis:could focal dystonia be a subclinical etiological factor显示文摘 | Doménech J Tormos JM Barrios C | 2010 | Eur Spine J2010，19，2： | 1 |
| 12 | Enabling technology for knowledge sharing显示文摘 | Fikes R E Gruber T R | 1991 | AIMagazine1991，12，3： | 1 |
| 13 | A new atrial septostomy technique显示文摘 | Park SC Zuberbuhler JR Neches WH | 1975 | Cathet Cardivasc Diagn1975，1，2： | 1 |
| 14 | Enabling technology for knowledge sharing显示文摘 | Neches R Fikes R Finin T | 1991 | AI Magazine1991，12，3： | 1 |
| 15 | Fenton and photoFenton oxidation of textile effluents显示文摘 | Pérez M Torrades F Domènech X | | 0，，11： | 1 |
| 16 | Enabling Technology for Knowledge Sharing显示文摘 | Neches R Fikes R Finin T | 1991 | AI Magazine1991，12，3： | 1 |
| 17 | Enabling Technology for Knowledge Sharing显示文摘 | NECHES R FIKES R E GRUBER T R | 1991 | AI Magazine1991，12，3： | 1 |
| 18 | Cost-effective use of echocardiography in children with Kawasaki disease显示文摘 | Scott JS Ettedgui JA Neches WH | 1999 | Pediatrics1999，104，5： | 1 |
| 19 | Plant metallothionein domains:functional insight into physiological metal binding and protein folding显示文摘 | Jordi Domènech Gisela Mir Sllvia Atrian | 2006 | Biochimie2006，88，： | 1 |
| 20 | Human Capital Inequality and Economic Growth : Some New Evidence 显示文摘 | CASTELL6 A DOM~NECH R | 2002 | The Economic Journal2002，112，478： | 1 |
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