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| 1 | Knockout mouse models of insulin signaling: Relevance past and future显示文摘Insulin resistance is a hallmark of type 2 diabetes. In an effort to understand and treat this condition, re searchers have used genetic manipulation of mice to uncover insulin signaling pathways and determine the effects of their perturbation. After decades of research much has been learned, but the pathophysiology o insulin resistance in human diabetes remains contro versial, and treating insulin resistance remains a chal lenge. This review will discuss limitations of mouse models lacking select insulin signaling molecule genes In the most influential mouse models, glucose metabo lism differs from that of humans at the cellular, organ and whole-organism levels, and these differences limi the relevance and benefit of the mouse models both in terms of mechanistic investigations and therapeutic development. These differences are due partly to im mutable differences in mouse and human biology, and partly to the failure of genetic modifications to produce an accurate model of human diabetes. Several fac tors often limit the mechanistic insights gained from experimental mice to the particular species and strain including: developmental effects, unexpected meta bolic adjustments, genetic background effects, and technical issues. We conclude that the limitations and weaknesses of genetically modified mouse models of insulin resistance underscore the need for redirection of research efforts toward methods that are more directly relevant to human physiology. | Anne E Bunner P Charukeshi Chandrasekera Neal D Barnard | 2014 | World Journal of Diabetes2014，5，2： | 9 |
| 2 | 2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。 | Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，1： | 6 |
| 3 | Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease显示文摘AIM To study the genetic association and epistatic interaction of the interleukin(IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease(IBD). METHODS A total of 159 pediatric inflammatory IBD patients(Crohn's disease,n = 136; ulcerative colitis,n = 23) and 129 matched controls were studied for genetic association of selected single nucleotide polymorphisms(SNPs) of the IL-10 gene and the genes IL10 RA,IL10 RB,STAT3,and HO1,from the IL-10/STAT3 signaling pathway. As interactions between SNPs from different loci may significantly affect the associated risk for disease,additive(a) and dominant(d) modeling of SNP interactions was also performed to examine highorder epistasis between combinations of the individual SNPs. RESULTS The results showed that IL-10 rs304496 was associated with pediatric IBD(P = 0.022),but no association was found for two other IL-10 SNPs,rs1800872 and rs2034498,or for SNPs in genes IL10 RA,IL10 RB,STAT3,and HO1. However,analysis of epistatic interaction among these genes showed significant interactions:(1) between two IL-10 SNPs rs1800872 and rs3024496(additive-additive P = 0.00015,Bonferroni P value(Bp) = 0.003);(2) between IL-10 RB rs2834167 and HO1 rs2071746(dominant-additive,P = 0.0018,Bp = 0.039); and(3) among IL-10 rs1800872,IL10 RB rs2834167,and HO1 rs2071746(additivedominant-additive,P = 0.00015,Bp = 0.005),as well as weak interactions among IL-10 rs1800872,IL-10 rs3024496,and IL-10RA(additive-additive-additive,P = 0.003; Bp = 0.099),and among IL10 RA,IL10 RB,and HO1 genes(additive-dominant-additive,P = 0.008,Bp = 0.287).CONCLUSION These results indicate that both the IL-10 gene itself,and through epistatic interaction with genes within the IL-10/STAT3 signaling pathway,contribute to the risk of pediatric IBD. | Zhenwu Lin Zhong Wang John P Hegarty Tony R Lin Yunhua Wang Sue Deiling Rongling Wu Neal J Thomas Joanna Floros | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 4 | Effect of planar anisotropy on wrinkle formation tendencies in curved sheets 显示文摘 | TUGCUA P NEALE K W | 2001 | International Journal of Mechanical Sciences2001，43，3： | 2 |
| 5 | Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS显示文摘 | Simon P Dunlop David Jenkins Keith R Neal Robin C Spiller | 2003 | Gastroenterology2003，，6： | 2 |
| 6 | Evaluation of melt-grown, ZnO single crystals for use as alpha-particle detectors显示文摘 | HAUSLADEN P A NEAL J S MIHALCZO J T | 2005 | Nucl Instrum Methods2005，241，： | 1 |
| 7 | On pre-straining and the evolution of material anisotropy in sheet metals显示文摘 | WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W | 2005 | Int J Plasticity2005，21，： | 1 |
| 8 | Rapid Ped-2E9 Cell- Based Cytotoxicity Analysis and Genotyping of Bacillus Species 显示文摘 | GRAY K M BANADA P P O'NEAL E | 2005 | Journal of clinical Microbiology2005，43，12： | 1 |
| 9 | Rapid solidification processing of magnesium-lithium alloys 显示文摘 | MESCHTE P J JE O'Neal | 1984 | Metallurgical and Materials Transactions A1984，15，1： | 1 |
| 10 | Relationship of campylobacter toxigenicity in vitro to the development of post-infectious irritable bowel syndrome显示文摘 | Jenkins D Neal K | 2001 | J Infect Dis2001，184，5： | 1 |
| 11 | Percutaneous vertebroplasty treat ment of steroid-induced osteoporotic compression fractures 显示文摘 | Ohn MM Michelle P Neal N | 1998 | Arthritis and Rheumatism1998，41，1： | 1 |
| 12 | Histaminoid reac- tions associated with rocuronium 显示文摘 | Neal S M Manti P R Gadiyar V | 2000 | Br J Anaesth2000，84，1： | 1 |
| 13 | The impact of organizational climate on safety climate and individual behavior显示文摘 | Neal A Griffin M A Hart P M | 2000 | Safety Science2000，34，13： | 1 |
| 14 | A role for oxida- tive stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats显示文摘 | Ereal N Neal R Treeratphan P | 2000 | Arch Environ Con- tam Toxicol2000，39，2： | 1 |
| 15 | Roles of the complement system inhuman neurodegenerative disorders:pro-inflammatory and tissue remodelingactivities显示文摘 | Casque P Neal JW Singhrao SK | 2002 | Mol Neurobiol2002，25，1： | 1 |
| 16 | Challenges in the Packaging of MEMS显示文摘 | Malshe A P O'Neal C Singh S B | | 0，，03： | 1 |
| 17 | The basic reproduction number and the probability of extinction for a dynamic epidemic model显示文摘 | Neal P | 2012 | Mathematical Biosciences2012，236，1： | 1 |
| 18 | Comparative analysis of flow eytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia显示文摘 | Neale GA Coustan-Smith E Stow P Pan Q Chen X Pui CH Campana D | 2004 | Leukemia2004，18，5： | 1 |
| 19 | Carbon uptake in a marine diatom during acute exposure to ultraviolet B radiation: relative importance of damage and repair显示文摘 | LESSER M P CULLEN J J NEALE P J | 1994 | Journal of Phycology1994，30，： | 1 |
| 20 | Interactive effects of ozone depletion and vertical mixing on photosynthesis of Antarctic phytoplankton显示文摘 | NEALE P J DAVIS R F CULLEN J J | 1998 | Nature1998，392，： | 1 |
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