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| 1 | Translational approaches: From fatty liver to non-alcoholic steatohepatitis显示文摘Over the past few decades, non-alcoholic fatty liver disease(NAFLD) has become one, if not the most common,cause of chronic liver disease affecting both adults and children. The increasing number of cases at an early age is the most worrying aspect of this pathology, since it provides more time for its evolution. The spectrum of this disease ranges from liver steatosis to steatohepatitis, fibrosis and in some cases, hepatocellular carcinoma. NAFLD may not always be considered a benign disease and hepatologists must be cautious in the presence of fatty liver. This should prompt the use of the available experimental models to understand better the pathogenesis and to develop a rational treatment of a disease that is dangerously increasing. In spite of the growing efforts, the pathogenesis of NAFLD is still poorly understood. In the present article we review the most relevant hypotheses and evidence that account for the progression of NAFLD to non-alcoholic steatohepatitis(NASH) and fibrosis. The available in vitro and in vivo experimental models of NASH are discussed and revised in terms of their validity in translational studies. These studies must be aimed at the discovery of the still unknown triggers or mediators that induce the progression of hepatic inflammation, apoptosis and fibrosis. | Natalia Rosso Norberto C Chavez-Tapia Claudio Tiribelli Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，27： | 14 |
| 2 | A morphological and structural study of uhem/P84 copolyimide dual-layer hollow fiber membranes with delamination-free morpho/ogy 显示文摘 | Natalia W Tai S C William B | 2007 | Journal of Membrane Science ( S1006-2289 )2007，294，： | 1 |
| 3 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 4 | Predicting arterial stiffness from the digital volume pulse waveform显示文摘 | ALTY S R NATALIA A J MILLASSEAU S C | 2007 | IEEE Transactions on Biomedical Engineering2007，54，12： | 1 |
| 5 | Influence of carbohydrates on the stability and structure of a hyperglycosylated human interferon alpha mutein显示文摘 | Natalia C Marina E Ricardo K | 2010 | Biochimie2010，92，： | 1 |
| 6 | The governance of nonprofit organizations : empirical evidence from nongovernmental development organizations in Spain显示文摘 | Pablo A A Natalia M C Elena M R | | Nonprofit and Voluntary Sector Quarterly0，40，： | 1 |
| 7 | Recovery of valuable elements from spent Li-batteries 显示文摘 | JESSICA F P NATALIA G B JLrLIO C A | 2008 | Journal of Hazardous Materi- als2008，150，： | 1 |
| 8 | Solid-phase mi- croextraction as a clean-up and preconcentration proce- dures for organochlorine pesticides determination in fish tissue by gas chromatography with electron capture detec- tion显示文摘 | Natalia F U Giusepp C Elisa B G | 2003 | J Chromatogr A2003，1017，： | 1 |
| 9 | Solid - phase microextraction as a clean - up and preconcentration procedure for organochlorine pesticides determination in fish tissue by gas chromatography with electron capture detection 显示文摘 | Natalia F U Giuseppe C Elisa B G | 2003 | Journal of Chromatography A2003，1017，： | 1 |
| 10 | Differential responses between mature and young leaves of sunflower plants to oxidative stress caused by water deficit显示文摘 | INES C NATALIA C TEREZINHA de F F ANA C C | 2010 | Ciincia Rural Santa Maria2010，40，6： | 1 |
| 11 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 12 | The Governance of Nonprofit Organizations: Empirical Evidence From Nongovernmental Development Organizations in Spain显示文摘 | Pablo A A Natalia M C Elena M R | 2011 | Nonprofit and Voluntary Sector Quarterly2011，，40： | 1 |
| 13 | University effects on regional innovation 显示文摘 | Robin C Natalia Z | 2013 | Research Policy2013，42，3： | 1 |
| 14 | Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance 显示文摘 | Qi C Natalia ID Joan DF | 2005 | Proc Natl Acad Sci2005，102，2： | 1 |
| 15 | Measuring the Value of Time Formethadonemaintenance Clients:Willingness to Pay,Willingness to Accept,and the Wage Rate显示文摘 | Allen C Goodman | 2003 | Health Econ2003，，12： | 1 |
| 16 | Solid-phase microextraction as a clean-up and preconcentration procedure for organochlorine pesticides determination in fish tissue by gas chromatography with electron capture detection显示文摘 | Natalia F U Giuseppe C Elisa B G | 2003 | J Chromatogr A2003，，1017： | 1 |
| 17 | Probiotics: An alternative strategy for combating salmonellosis Immune mechanisms involved 显示文摘 | Natalia A C Alejandra M L Galdeano C M | 2012 | Food Res Int2012，45，2： | 1 |
| 18 | High phosphorus diet induces vascular calcification,a related decrease in bone mass and changes in the aortic gene expression显示文摘 | Pablo R Natalia C Jose L F | 2010 | Bone2010，46，： | 1 |
| 19 | Stir Bar Sorptive Extraction Coupled to Liquid Chromatography for the Analysis of Strobilurin Fungicides in Fruit Samples 显示文摘 | NATALIA C PILAR V NEREA A | 2010 | Journal of Chromatography A2010，，1217： | 1 |
| 20 | Determination of tin and titanium in soils,sediments and sludges using electrothermal atomic absorption spectrometry with slurry sample introduction显示文摘 | Ignacio L G Isabel A J Natalia C | 2004 | Talanta2004，62，： | 1 |
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