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| 1 | Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma显示文摘瞄准:为了评估免疫, interleukin-6 ( IL-6 )和从有肝细胞癌( HCC )和浆液的病人的肿瘤组织标本上的 IL-6 受体( IL-6R )的组织化学的本地化与 HCC 以及肝肝硬化( LC )在一组病人 IL-6 和 sIL-6R 铺平在一组有独自一个的 LC 并且在一个控制组的病人。方法:三组题目被学习:组我(n = 83 ) 受不了 HCC 和 LC,组 II (n = 72 ) 受不了独自一个的 LC 和组 III (n = 42 ) 同样健康的控制。所有病人有丙肝病毒感染。浆液 IL-6 和 IL-6R 层次用一个商业地可得到的 ELISA 工具包被决定。Immunohistochemistry 对 IL-6 和 IL-6R 用 streptavidin-biotin 建筑群和兔子 polyclonal 抗体被执行。结果:Immunohistochemistry 分析显示出媒介到强壮细胞质并且为 IL-6 和 IL-6R 的膜反应分别地在 HCC 的至少 40% 盒子,而肝肝硬化病人和控制为 IL-6 是否定的或为 IL-6R 显示出很温和、焦点的像点的细胞质的反应。在 HCC 组的浆液 IL-6 层次比在 LC 和控制组的那些显著地高(P <
0.0001 ) 。在在 3 个组之中的 sIL-6R 集中没有有效差量。当有 HCC 的病人根据 Okuda 的分类被划分成组时, IL-6 和 sIL-6R 水平的重要浆液增加从舞台被观察我上演 III (P <
0.02, P <
0.0005 ) 。当 HCC 和 LC 病人根据孩子呸被划分成肝硬化严厉的 3 个班时,在 HCC 病人的价值比在为各相应的班的 LC 病人的那些显著地高(P <
0.01 ).CONCLUSION:在 HCC 病人的 IL-6 浆液层次比在 LC 病人和控制的那些高,建议由肿瘤的房间的这 cytokine 的增加的生产。sIL-6R 价值在所有组是类似的,仅仅在阶段 III HCC 病人增加。这些数据建议他们与肿瘤的团而非与剩余的工作有一种更靠近的关系肝的质量。 | Soresi Maurizio Giannitrapani Lydia D'Antona Fabio Florena Ada Maria La Spada Emanuele Terranova Angela Cervello Melchiorre D'Alessandro Natale Montalto Giuseppe | 2006 | World Journal of Gastroenterology2006，12，16： | 25 |
| 2 | Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis显示文摘AIM: To investigate the association of cyclooxygenase-2(COX-2) expression with angiogenesis and the number and type of inflammatory cells (macrophages/Kupffer cells;mast cells) within primary hepatocellular carcinoma (HCC)tissues and adjacent non-tumorous (MT) tissues.METHODS: Immunohistochemistry for COX-2, CD34,CD68 and mast cell tryptase (MCT) was performed on 14 well-characterized series of liver-cirrhosis-associated HCC patients. COX-2 expression and the number of inflammatory cells in tumor lesions and surrounding liver tissues of each specimen were compared. Moreover,COX-2, CD34 staining and the number of inflammatory cells in areas with different histological degrees within each tumor sample were comparatively analyzed.RESULTS: The percentage of COX-2 positive cells was significantly higher in NT tissues than in tumors. COX-2 expression was higher in well-differentiated HCC than in poorly-differentiated tissues. Few mast cells were observed within the tumor mass, whereas a higher number was observed in the surrounding tissue, especially in peri-portal spaces of NT tissues. Abundant macrophages/Kupffer cells were observed in NT tissues, whereas the number of cells was significantly lower in the tumor mass.However, a higher cell number was observed in the well-differentiated tumor and progressively decreased in relation to the differentiation grade. Within the tumor, a positive correlation was found between COX-2 expression and the number of macrophages/Kupffer cells and mast cells. Moreover, there was a positive correlation between CD34 and COX-2 expression in tumor tissues. Comparison between well- and poorly-differentiated HCC showed that the number of CD34-positive cells decreased with dedifferentiation. However, COX-2 was the only independent variable showing a positive correlation with CD34 in a multivariate analysis.CONCLUSION: The presence of inflammatory cells and COX-2 expression in liver tumor suggests a possible relationship with tumor angiogenesis. COX-2 expressing cells and the number of macrophages/Kupffer cells and mast cells decrease with progression of the disease. | Melchiorre Cervello Daniela Foderà Ada Maria Florena Maurizio Soresi Claudio Tripodo Natale D'Alessandro Giuseppe Montalto | 2005 | World Journal of Gastroenterology2005，11，30： | 21 |
| 3 | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients显示文摘The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense debate.The start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body.This variability seems to be correlated with the presence of genetic polymorphisms.Genotyping is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given gene.However,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that medication.At present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of tacrolimus.However,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and toxicity.For these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing. | Alessio Provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 4 | Transcranial Doppler ultrasonography: From methodology to major clinical applications显示文摘Non-invasive Doppler ultrasonographic study of cerebral arteries [transcranial Doppler(TCD)] has been extensively applied on both outpatient and inpatient settings. It is performed placing a low-frequency(≤ 2 MHz) transducer on the scalp of the patient over specific acoustic windows, in order to visualize the intracranial arterial vessels and to evaluate the cerebral blood flow velocity and its alteration in many different conditions. Nowadays the most widespread indication for TCD in outpatient setting is the research of right to left shunting, responsable of so called 'paradoxical embolism', most often due to patency of foramen ovale which is responsable of the majority of cryptogenic strokes occuring in patients younger than 55 years old. TCD also allows to classify the grade of severity of such shunts using the so called 'microembolic signal grading score'. In addition TCD has found many useful applications in neurocritical care practice. It is useful on both adults and children for day-to-day bedside assessment of critical conditions including vasospasm in subarachnoidal haemorrhage(caused by aneurysm rupture or traumatic injury), traumatic brain injury, brain stem death. It is used also to evaluate cerebral hemodynamic changes after stroke. It also allows to investigate cerebral pressure autoregulation and for the clinical evaluation of cerebral autoregulatory reserve. | Antonello D'Andrea Marianna Conte Massimo Cavallaro Raffaella Scarafile Lucia Riegler Rosangela Cocchia Enrica Pezzullo Andreina Carbone Francesco Natale Giuseppe Santoro Pio Caso Maria Giovanna Russo Eduardo Bossone Raffaele Calabrò | 2016 | World Journal of Cardiology2016，8，7： | 10 |
| 5 | Multifactorial nature of hepatocellular carcinoma drug resistance: Could plant polyphenols be helpful?显示文摘主要肝细胞癌(HCC ) 是导致高死亡并且最经常展出差的回答介绍药治疗的一个相当经常的肿瘤。清楚地,这恶意的生物的底的彻底的理解可能为它的治疗建议新策略。这里,我们检验证据两“药理学”机制(例如药 transporter 或 detoxification 酶在表示上) 并且在另外的关键因素的改变,包括国际机场(Apoptosis 蛋白质禁止) ,在房间幸存和增长的改进包含了可以决定 HCC 的治疗学的抵抗;我们也在抄写因素的激活的过程加重可能的角色,象 NF-kappaB 一样,能够同时起来调整讨论的机制。在这个基础上,我们最后评论象植物多酚一样的自然多指向的 antitumoral 代理人的可能的使用在 HCC 完成促进感受性到处理。 | Natale D'Alessandro Paola Poma Giuseppe Montalto | 2007 | World Journal of Gastroenterology2007，13，14： | 3 |
| 6 | Human chorionic go- nadotropin level as a predictor of trophoblastic infiltration into the tubal wall in ectopic pregnancy:a blinded study 显示文摘 | Natale A Candiani M Medo D | 2003 | Fertil steril2003，79，4： | 1 |
| 7 | p38 MAPK signaling during routine preimplantation development 显示文摘 | Natale D R Paliga A J Beier F | 2004 | Dev Biol2004，268，1： | 1 |
| 8 | Metalloporphyrins Based Artificial Olfactory Receptors显示文摘 | Natale C D Paolesse R D' Amico A | 2007 | Sensors and Actuators B2007，121，： | 1 |
| 9 | The COG database: new developments in phylogenetic classification of proteins from complete genomes显示文摘 | Natale D A Garkavtsev I V | 2001 | Nucleic Acids Res2001，29，1： | 1 |
| 10 | Human chronic gonadotropin level as a predictor of trophoblastic infiltration into the tubal wall in ectopic pregnancy:a blinded study显示文摘 | Natale A Candiani M Merto D | 2003 | Fertility Sterility2003，79，4： | 1 |
| 11 | P38 mitogen activated protein kinase (MAPK) first regulates filamentous actin at the 8-16 cell stage during preimplantation development显示文摘 | Paliga A J Natale D R Watson A J | 2005 | Biol Cell2005，97，62： | 1 |
| 12 | Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma:final results of the Southern Italy Cooperative Oncology Group Trial 0108显示文摘 | COMELLA P NATALE D FARRIS A | 2005 | Cancer2005，104，2： | 1 |
| 13 | Ultrasonic Doppler Velocimetry in Liquid Gallium 显示文摘 | Brito D Natal H C Cardin P | 2001 | Experiments in Fluids2001，31，6： | 1 |
| 14 | Human chorionic gonadotrop in levers as predictor of trophoblastic in filtration to the tubal wall inectopic pregnancy:a blind study显示文摘 | Natale A Candiani M Merlo D | 2003 | Fertil Steril2003，79，： | 1 |
| 15 | Electronic nose and electronic tongue integration for improved classification of clinical and food samples显示文摘 | NATALE C D PAOLESSE R MACAGNANO A | 2000 | Sensor Actuat B-them2000，64，1： | 1 |
| 16 | Phenomenological dynamic model of a magnetostrictive actuator显示文摘 | Davino D Natale C Pirozzi S | 2004 | Physica B2004，，4： | 1 |
| 17 | Post-traumatic peripheral facial nerve palsy: sur- gical and neuroradiological consideration in five cases of delayed onset 显示文摘 | Rotondo M D'Avanzo R Natale M | 2010 | Acta Neurochir (Wien)2010，152，： | 1 |
| 18 | Scheduling distributed real-time tasks with minimum jitter 显示文摘 | Stankovic J A | 2000 | IEEE Transactions on Computers2000，49，4： | 1 |
| 19 | Assessment by differential display-RT-PCR of mRNA transcript transitions and alpha-amanitin sensitivity during bovine preattachment development显示文摘 | Natale D R Kidder G M Westhusin M E | 2000 | Mol Reprod Dev2000，55，2： | 1 |
| 20 | Metalloporphyrins Based Artificial Olfactory Receptors显示文摘 | Natale C D Paolesse R D' Amico A | 2007 | Sensors and Actuators B2007，121，： | 1 |
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