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| 1 | Preventive effects of geranylgeranylacetone on rat ethanolinduced gastritis显示文摘AIM:To establish a rat ethanol gastritis model,we evaluated the effects of ethanol on gastric mucosa and studied the preventive effects of geranylgeranylacetone on ethanol-induced chronic gastritis.METHODS:One hundred male Sprague-Dawley rats were randomly divided into 4 equal groups:normal control group,undergoing gastric perfusion of normal saline(NS) by gastrogavage;model control group and 2 model therapy groups that underwent gastric perfusion with ethanol(distillate spirits with 56% ethanol content) by gastrogavage for 4 wk.Low or high doses of geranylgeranylacetone were added 1 h before ethanol perfusion in the 2 model therapy groups,while the same amount of NS,instead of geranylgeranylacetone was used in that model control group.The rats were then sacrificed and stomachs were removed.The injury level of the gastric mucosa was observed by light and electron microscopy,and the levels of prostaglandin 2(PGE 2),endothelin-1(ET-1) and nitric oxide(NO) were measured by radioimmunoassay and the Griess method.RESULTS:The gastric mucosal epidermal damage score(EDS;4.5) and ulcer index(UI;12.0) of the model control group were significantly higher than that of the normal control group(0 and 0 respectively,all P = 0.000).The gastric mucosal EDS and UI of the 2 model therapy groups(EDS:2.5 and 2.0;UI:3.5 and 3.0) were significantly lower than that of the model control group(all P < 0.01).There was no statistically significant difference between the low-dose and high-dose model therapy groups.The expression value of plasma ET-1 of the model control group was higher than that of the normal control group(P < 0.01) and the 2 model therapy groups(all P < 0.01).The expression values of gastric mucosal PGE 2 and serum NO of the model control group were lower than those of the normal control group(all P < 0.05) and the 2 model therapy groups(all P < 0.05).The thickness of the gastric mucous layerand the hexosamine content in the model control group were significantly lower than that in the normal control group(all P < 0.01) and the 2 model therapy groups(all P < 0.05).Scanning and transmission electron microscopy observation showed that in the model control group,the epithelial junctions were vague,the intercellular joints disappeared and damage of the intracellular organelles were significantly worse than those in the normal control group.However,in the 2 model therapy groups,damage to the intercellular joints and organelles was ameliorate relative to the model control group.CONCLUSION:Administration of geranylgeranylacetone was correlated with a more favorable pattern of gastric mucosa damage after ethanol perfusion.The mechanism could be related to regulation of ET-1,NO and PGE 2. | Jian-Wen Ning Guan-Bin Lin Feng Ji Jia Xu Najeeb Sharify | 2012 | World Journal of Gastroenterology2012，18，18： | 12 |
| 2 | 铊在多壁碳纳米管上的吸附(英文)显示文摘多壁碳纳米管采用H2SO4,KMnO4,HNO3氧化处理后用于铊吸附研究。碳纳米管经处理后表面官能团增加,采用Bohmn滴定法确定了样品的表面官能团的量。当用于吸附铊时,氧化处理显著提高了其吸附能力。采用Langmuir方程进行拟合处理后获得原始碳纳米管、H2SO4,KMnO4,HNO3氧化处理后样品的吸附量分别为3.0,11.7,21.6 and 31.55mg/g。HNO3处理后具有对铊最佳的吸附性能。 | Saeed ur Rehman Najeeb Ullah Ali Reza Kamali Khurshid Ali Cemile Yerlikaya Hanif ur Rehman | 2012 | 新型炭材料2012，27，6： | 9 |
| 3 | Arterial stiffness: a brief review显示文摘大动脉的物理使硬是脉管的老化的中央范例。确实,在更大的中央动脉的系统使硬,例如大动脉的树,显著地在更老的个人贡献心血管的疾病并且是断然与收缩高血压,冠的动脉疾病,击,心失败和 atrial 纤维性颤动联系了,它在由世界健康组织在 2010 估计了的发展中的世界上是在发达国家并且也的死亡的领先的原因。更好,因此,动脉的僵硬的不太侵略、更精确的措施被开发了,它作为诊断索引, pathophysiological 标记和疾病的预兆的指示物证明有用。这篇文章介绍为脉管的研究和药的脉管的使硬,它的 pathophysiologic 决定因素和它的含意的结构的决定因素的评论。为估计脉管的僵硬的新技术的批评讨论也被介绍。 | Najeeb A SHIRWANY Ming-hui ZOU | 2010 | Acta Pharmacologica Sinica2010，31，10： | 6 |
| 4 | AMPK in cardiovascular health and disease显示文摘腺苷激活 Monophosphate 的蛋白质 Kinase (AMPK ) , serine/threonine kinase 和 Snf1/AMPK 蛋白质 kinase 家庭的一个成员,由三个蛋白质子单元组成一起做功能的酶。AMPK,在很多纸巾被表示,被上升 allosterically 在 AMP 激活:ATP 比率(在低 ATP 或精力即弄空的状态) 。AMPK 激活的网效果是停止消费的精力(anabolism ) 小径但是支持保存的精力(分解代谢) 细胞的小径。AMPK 经常因此被称了鈥渕e tabolic 主人开关鈥吗?AMPK 也在心血管的系统起一个关键生理的作用。增加的证据建议 AMPK 可能也由对氧化应力作出回应作为一个传感器工作。主要重要地, AMPK 调制内长的抗氧化剂基因表示或压制氧化剂的生产。AMPK 由在心和脉管的纸巾上保证最佳氧化还原作用平衡支持心血管的动态平衡。不正常的 AMPK 被认为位于几个心血管的病理下面。这里,我们在心血管的系统从它的结构和发现考察这 kinase 到它的适应、不适应的角色的当前的知识。 | Najeeb A SHIRWANY Ming-Hui ZOU | 2010 | Acta Pharmacologica Sinica2010，31，9： | 6 |
| 5 | GNP6,a novel allele of MOC1,regulates panicle and tiller development in rice显示文摘The yield of rice is mostly affected by three factors,namely,panicle number,grain number and grain weight.Variation in panicle and grain numbers is mainly caused by tiller and panicle branches generated from axillary meristems(AMs).MOC1 encodes a putative GRAS family nuclear protein that regulates AM formation.Although several alleles of MOC1 have been identified,its variation in germplasm resources remains unclear.In the present study we characterized a novel mocl allele named gnp6 which has a thymine insertion in the coding sequence of the SAW motif in the GRAS domain.This mutation causes arrested branch formation.The SAW motif is necessary for nuclear localization of GNP6/MOC1 where it functions as a transcription factor or co-regulator.Haplotype analysis showed that the coding region of GNP6/MOC1 was conserved without any non-synonymous mutations in 240 rice accessions.However,variation in the promoter region might affect the expression of it and its downstream genes.Joint haplotype analysis of GNP6/MOC1 and MOC3 showed that haplotype combinations H9,H10 and H11,namely MOC1-Hap1 in combination with MOC3-Hap3,MOC3-Hap4 or MOC3-Hap5 could be bred to promote branch formation.These findings will enrich the genetic resources available for rice breeders. | Zhanying Zhang Xingming Sun Xiaoqian Ma Bingxia Xu Yong Zhao Zhiqi Ma Gangling Li Najeeb Ullah Khan Yinghua Pan Yuntao Liang Hongliang Zhang Jinjie Li Zichao Li | 2021 | The Crop Journal2021，9，1： | 6 |
| 6 | 变齿厚RV减速器动态特性分析显示文摘变齿厚RV减速器是一种高性能精密传动装置,其动态特性对整机性能有重要影响。根据变齿厚RV减速器传动原理及结构特点,从系统角度出发,考虑轮齿的时变啮合刚度、轴承刚度、碟簧刚度、阻尼和传递误差等因素,基于Lagrangian方程,建立了耦合两级传动的整机弯-扭-轴耦合动力学模型。对样机的动态啮合力、构件动态响应及传动误差等特性进行了分析,研究了参数变化对这些性能指标的影响规律。研究结果可为变齿厚RV减速器的动态特性分析及优化提供理论依据。 | 杜雪松 黄玉成 朱才朝 ULLAH Najeeb 胡瑞 亓传宇 | 2020 | 振动与冲击2020，39，19： | 4 |
| 7 | Black phosphorus-based field effect transistor devices for Ag ions detection显示文摘Black phosphorus(BP), an attractive two-dimensional(2 D) semiconductor, is widely used in the fields of optoelectronic devices, biomedicine, and chemical sensing. Silver ion(Ag^+), a commonly used additive in food industry, can sterilize and keep food fresh. But excessive intake of Ag^+will harm human health. Therefore, high sensitive, fast and simple Ag+detection method is significant. Here, a high-performance BP field effect transistor(FET) sensor is fabricated for Ag^+detection with high sensitivity, rapid detection speed, and wide detection concentration range. The detection limit for Ag^+is 10^(-10) mol/L. Testing time for each sample by this method is 60 s. Besides, the mechanism of BP-FET sensor for Ag^+detection is investigated systematically. The simple BP-FET sensor may inspire some relevant research and potential applications, such as providing an effective method for the actual detection of Ag^+, especially in witnessed inspections field of food. | 王慧德 David K Sang 郭志男 曹睿 赵劲来 Muhammad Najeeb Ullah Shah 范涛健 范滇元 张晗 | 2018 | Chinese Physics B2018，27，8： | 4 |
| 8 | Variations in OsSPL10 confer drought tolerance by directly regulating OsNAC2 expression and ROS production in rice显示文摘Drought is a major factor restricting the production of rice(Oryza sativa L.).The identification of natural variants for drought stress-related genes is an important step toward developing genetically improved rice varieties.Here,we characterized a member of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)family,OsSPL10,as a transcription factor involved in the regulation of drought tolerance in rice.OsSPL10 appears to play a vital role in drought tolerance by controlling reactive oxygen species(ROS)production and stomatal movements.Haplotype and allele frequency analyses of OsSPL10 indicated that most upland rice and improved lowland rice varieties harbor the OsSPL10Hap1allele,whereas the OsSPL10Hap2allele was mainly present in lowland and landrace rice varieties.Importantly,we demonstrated that the varieties with the OsSPL10Hap1allele showed low expression levels of OsSPL10 and its downstream gene,OsNAC2,which decreases the expression of OsAP37 and increases the expression of OsCOX11,thus preventing ROS accumulation and programmed cell death(PCD).Furthermore,the knockdown or knockout of OsSPL10 induced fast stomatal closure and prevented water loss,thereby improving drought tolerance in rice.Based on these observations,we propose that OsSPL10 confers drought tolerance by regulating OsNAC2 expression and that OsSPL10Hap1could be a valuable haplotype for the genetic improvement of drought tolerance in rice. | Yingxiu Li Shichen Han Xingming Sun Najeeb Ullah Khan Qun Zhong Zhanying Zhang Hongliang Zhang Feng Ming Zichao Li Jinjie Li | 2023 | Journal of Integrative Plant Biology2023，65，4： | 2 |
| 9 | 除草剂丙酯草醚对大麦的影响和支链氨基酸对其生长的恢复作用(英文)显示文摘目的:评价除草剂丙酯草醚对大麦生长的影响,探讨外源添加支链氨基酸对其生长的恢复作用。创新点:从除草剂丙酯草醚作用机理出发,阐明了外源添加支链氨基酸对丙酯草醚作用下大麦各项生理和生长指标的缓解作用,为生长调节物质的进一步开发利用提供实验依据。方法:采用水培和大田实验相结合的方法,研究了除草剂丙酯草醚对大麦生长的影响,并通过进一步测定大麦幼苗各项生理指标和支链氨基酸浓度,表明100mg/L支链氨基酸可显著缓解丙酯草醚对大麦的生理损伤,从而恢复其生长。结论:外源添加支链氨基酸能够缓解除草剂丙酯草醚对大麦生长的抑制作用。 | Ling XU Jian-yao SHOU Rafaqat Ali GILL Xiang GUO Ullah NAJEEB Wei-jun ZHOU | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，1： | 2 |
| 10 | 茶树磷酸烯醇式丙酮酸转运子基因CsPPT的克隆与表达分析显示文摘以白叶1号为试验材料,通过RT-PCR和RACE技术克隆获得茶树磷酸烯醇式丙酮酸转运子基因Cs PPT(Gen Bank登录号:KJ652972)。Cs PPT完整ORF长度为1 227 bp,编码408个氨基酸,蛋白分子量为44.7k Da,理论等电点为10.16;无信号肽位点,属于非分泌型蛋白;建立了茶树Cs PPT蛋白的系统发育树;磷酸化修饰预测该蛋白质多肽链中共有26个磷酸化位点;TMHMM预测表明Cs PPT蛋白为跨膜蛋白;亚细胞定位发现,Cs PPT蛋白定位于叶绿体上,推测Cs PPT蛋白可能定位于叶绿体膜上。荧光定量PCR结果表明Cs PPT基因在茶树花中表达量最高,其次为芽、叶和嫩茎,根中最低。 | 赵真 陈暄 王明乐 王伟东 Najeeb Ahmed 黎星辉 | 2015 | 茶叶科学2015，35，5： | 2 |
| 11 | Haploid and doubled haploid techno-logy显示文摘 | Xu L Najeeb U Tang G X | 2007 | Adv Bot Res2007，45，： | 1 |
| 12 | Induction of tetraploidy in Juncus effusus by Colchicine显示文摘 | Xu L Najeeb U Naeem M S Daud M K Cao J S Gong H J Shen W Q Zhou W J | 2010 | Biologia Plantarum2010，54，4： | 1 |
| 13 | Induction of tetraploidy in Juncus effusus by colchicine显示文摘 | XU L NAJEEB U NAEEM M S | | 0，，04： | 1 |
| 14 | Nanomodified Peek Dental Implants: Bioactive Composites and Surface Modification-A Review显示文摘 | Najeeb S Khurshid Z Matinlinna J P | 2015 | Int J Dent2015，2015，38： | 1 |
| 15 | Primary plasma cell leukemia occuring in the young显示文摘 | Raj RS Najeeb S Aruna R | 2003 | Indian J Cancer2003，40，3： | 1 |
| 16 | Cadmium-induced functional and ultrastructural alterations in roots of two transgenic cotton cultivars显示文摘 | M.K. Daud Yuqiang Sun M. Dawood Y. Hayat M.T. Variath Yu-Xiang Wu Raziuddin Ullah Mishkat Salahuddin Ullah Najeeb Shuijin Zhu | 2008 | Journal of Hazardous Materials2008，，1： | 1 |
| 17 | An Implementation of Haar Wavelet Based Method for Numerical Treatment of Time-fractional Schrdinger and Coupled Schrdinger Systems显示文摘The objective of this paper is to solve the timefractional Schr¨odinger and coupled Schr¨odinger differential equations(TFSE) with appropriate initial conditions by using the Haar wavelet approximation. For the most part, this endeavor is made to enlarge the pertinence of the Haar wavelet method to solve a coupled system of time-fractional partial differential equations. As a general rule, piecewise constant approximation of a function at different resolutions is presentational characteristic of Haar wavelet method through which it converts the differential equation into the Sylvester equation that can be further simplified easily. Study of the TFSE is theoretical and experimental research and it also helps in the development of automation science,physics, and engineering as well. Illustratively, several test problems are discussed to draw an effective conclusion, supported by the graphical and tabulated results of included examples, to reveal the proficiency and adaptability of the method. | Najeeb Alam Khan Tooba Hameed | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 1 |
| 18 | RBF Based Localized Method for Solving Nonlinear Partial Integro-Differential Equations显示文摘In this work,a numerical scheme is constructed for solving nonlinear parabolictype partial-integro differential equations.The proposed numerical scheme is based on radial basis functions which are local in nature like finite difference numerical schemes.The radial basis functions are used to approximate the derivatives involved and the integral is approximated by equal width integration rule.The resultant differentiation matrices are sparse in nature.After spatial approximation using RBF the partial integro-differential equations reduce to the system of ODEs.Then ODEs system can be solved by various types of ODE solvers.The proposed numerical scheme is tested and compared with other methods available in literature for different test problems.The stability and convergence of the present numerical scheme are discussed. | Marjan Uddin Najeeb Ullah Syed Inayat Ali Shah | 2020 | Computer Modeling in Engineering & Sciences2020，，6： | 1 |
| 19 | Laryngotracheal reconstruction in total laryngotracheal transection 显示文摘 | Ajmal M Najeeb T | 2008 | J Coil Physicians Surg Pak2008，18，2： | 1 |
| 20 | High-Performance Photore- sponse from Single-Walled Carbon Nanotube-Zinc Oxide Hetero- junctions 显示文摘 | Chang J Najeeb C K Lee J H | 2011 | Journal of Physics D : Applied Physics2011，44，09： | 1 |
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