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| 1 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 2 | Micro RNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity显示文摘Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific mi RNA may display the effects of a tumor suppressor or oncogene. Altered mi RNA expression is found in colorectal cancer(CRC) and patterns of mi RNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum mi RNA and fecal mi RNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of mi RNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC. | Michael Hollis Kavitha Nair Arpita Vyas Lakshmi Shankar Chaturvedi Sahil Gambhir Dinesh Vyas | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 3 | A BAC clone of MDV strain GX0101 with REV-LTR integration retained its pathogenicity显示文摘The complete genome of Marek's disease virus (MDV) strain GX0101, which was integrated with the LTR sequences of REV, was cloned in Escherichia coli as a bacterial artificial chromosome (BAC). BAC vector sequences were introduced into the US2 locus of the MDV genome by homologous recombination. The viral DNA containing the BAC vector was used to transform Escherichia coli strain of DH10B. Then the recombinant virus was successfully rescued by transfection of the recombinant BAC DNA into primary chicken embryo fibroblast (CEF). This BAC viral clone was named bac-GX0101. When the reconstituted virus was inoculated into 1-day-old birds, visceral tumors could be detected as early as 62 d post infection. There was no difference in growth ability and pathogenicity to birds between the BAC derived virus and its parental virus. The BAC derived virus maintained its oncogenicity and immunosuppressive effects. In conclusion, the complete genome of GX0101 strain was successfully cloned into BAC and the infectious clone was rescued. With the powerful BAC manipulation system, the infectious clone will provide a useful tool for further understanding the functional roles of the inserted REV-LTR sequence in the GX0101 strain of MDV. | SUN AiJun LAWRENCE Petherbridge ZHAO YuGuang LI YanPeng NAIR Venugopal K CUI ZhiZhong | 2009 | Chinese Science Bulletin2009，54，15： | 15 |
| 4 | Coronary artery anomalies overview: The normal and the abnormal显示文摘The aim of this review is to give a comprehensive and concise overview of coronary embryology and normal coronary anatomy, describe common variants of normal and summarize typical patterns of anomalous coronary artery anatomy. Extensive iconography supports the text, with particular attention to images obtained in vivo using non-invasive imaging. We have divided this article into three groups, according to their frequency in the general population: Normal, normal variant and anomaly. Although congenital coronary artery anomalies are relatively uncommon, they are the second most common cause of sudden cardiac death among young athletes and therefore warrant detailed review. Based on the functional relevance of each abnormality, coronary artery anomalies can be classified as anomalies with obligatory ischemia, without ischemia or with exceptional ischemia. The clinical symptoms may include chest pain, dyspnea, palpitations, syncope, cardiomyopathy, arrhythmia, myocardial infarction and sudden cardiac death. Moreover, it is important to also identify variants and anomalies without clinical relevance in their own right as complications during surgery or angioplasty can occur. | Adriana DM Villa Eva Sammut Arjun Nair Ronak Rajani Rodolfo Bonamini Amedeo Chiribiri | 2016 | World Journal of Radiology2016，8，6： | 14 |
| 5 | 基于同步量测全尺度能量的配电网高阻故障动态检测方法显示文摘高阻故障(high impedance fault,HIF)可能造成重大经济损失、对人身安全构成威胁,因此HIF检测对配电网来说比较重要,而微型相量测量单元在配电网中的使用为配电网HIF动态检测提供有利条件。文章针对配电网HIF检测问题,提出一种基于同步全尺度能量的配电网高阻故障动态检测方法。检测包括2个阶段:第一阶段使用克尔内克积和变分模态分解将工频电流信号分解为多个固有模态,然后采用Teager-Kaiser能量算子计算所有尺度能量;第二阶段使用具有复合指标的改进主元分析方法对第一阶段获得的尺度能量矩阵进行检测,最后通过判别标准实现对HIF的识别。仿真和实例试验表明,该算法能够准确检测出HIF,对过渡阻抗、噪声均具有鲁棒性。 | 刘洋 赵艳雷 Nirmal Nair 姚维强 | 2020 | 电网技术2020，44，8： | 11 |
| 6 | Superhydrophobic Surfaces Produced by Applying a Self- Assembled Monolayer to Silicon Micro/Nano-Textured Surfaces显示文摘A novel way of producing superhydrophobic surfaces by applying a self-assembled monolayer(SAM)to silicon micro/nano-textured surfaces is presented in this paper.The micro/nano-textured surfaces on silicon substrates were generated by the aluminum-induced crystallization(AIC)of amorphous silicon(a-Si)technique.Octadecyltrichlorosilane(OTS)SAMs were then applied to the textured surfaces by dip coating.The topography and wetting properties of the resulting surfaces were characterized using scanning electron microscopy(SEM)and a video-based contact angle measurement system.The results show that by introducing OTS SAMs on the silicon micro/nano-textured surfaces,superhydrophobic surfaces with water contact angles(WCAs)of 155°were obtained,as compared to the WCAs of OTS-modified smooth silicon surfaces of about 112°.Surface topography was found to directly influence the WCA as predicted by the Cassie-Baxter model. | Yong Song Rahul Premachandran Nair Min Zou Yongqiang Wang | 2009 | Nano Research2009，2，2： | 11 |
| 7 | Natural dietary anti-cancer chemopreventive compounds:redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells显示文摘许多饮食的 phytochemicals 展览象癌症那样的疾病的健康有益的效果 includingprevention ,以及神经病学,心血管,煽动性, andmetabolic diseases.Evolutionarily ,食草、杂食性的动物一直在摄取在“动物植物”之间的 plants.Thisinteraction 生态系统导致了机制包括 humans.Mammalian 房间由动物发展了的 detoxificationand 防卫的一个精致的系统,包括 humancells ,对这些饮食的 phytochemicals 作出回应由“ | Sujit NAIR Wenge LI Ah-Ng Tony KONG | 2007 | Acta Pharmacologica Sinica2007，28，4： | 9 |
| 8 | Risk of New-Onset Atrial Fibrillation in Elderly Patients with the Overlap Syndrome: A Retrospective Cohort Study显示文摘Background Co-existence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is referred to as overlap syndrome. Overlap patients have greater degree of hypoxia and pulmonary hypertension than patients with OSA or COPD alone. Studies showed that elderly patients with OSA alone do not have increased risk of atrial fibrillation (AF) but it is not known if overlap patients have higher risk of AF. Objective To determine whether elderly patients with overlap syndrome have an increased risk of AF. Methods In this single center, community-based retrospective cohort analysis, data were collected on 2,873 patients > 65 years of age without AF, presenting in the year 2006. Patients were divided into OSA group (n = 60), COPD group (n = 416), overlap syndrome group (n = 28) and group with no OSA or COPD(n = 2369). The primary endpoint was incidence of new-onset AF over the following two years. Logistic regression was performed to adjust for heart failure (HF), coronary artery disease, hypertension (HTN), cerebrovascular disease, cardiac valve disorders, diabetes mellitus, hyperlipidemia, chronic kidney disease (CKD) and obesity. Results The incidence of AF was 10% in COPD group, 6% in OSA group and 21% in overlap syndrome group (P < 0.05). After adjusting for age, sex, HF, CKD, and HTN, patientswith overlap syndrome demonstrated a significant association with new-onset AF (OR = 3.66, P = 0.007). HF, CKD and HTNwere also significantly associated with new-onset AF (P < 0.05). Conclusion Among elderly patients, the presence of overlap syndrome is associatedwith a marked increase in risk of new-onset AF as compared to the presence of OSA or COPDalone. | Harsha V. Ganga Sanjeev U. Nair Venkata K. Puppala Wayne L. Miller | 2013 | Journal of Geriatric Cardiology2013，10，2： | 9 |
| 9 | Robust Adaptive Gain Higher Order Sliding Mode Observer Based Control-constrained Nonlinear Model Predictive Control for Spacecraft Formation Flying显示文摘This work deals with the development of a decentralized optimal control algorithm, along with a robust observer,for the relative motion control of spacecraft in leader-follower based formation. An adaptive gain higher order sliding mode observer has been proposed to estimate the velocity as well as unmeasured disturbances from the noisy position measurements.A differentiator structure containing the Lipschitz constant and Lebesgue measurable control input, is utilized for obtaining the estimates. Adaptive tuning algorithms are derived based on Lyapunov stability theory, for updating the observer gains,which will give enough flexibility in the choice of initial estimates.Moreover, it may help to cope with unexpected state jerks. The trajectory tracking problem is formulated as a finite horizon optimal control problem, which is solved online. The control constraints are incorporated by using a nonquadratic performance functional. An adaptive update law has been derived for tuning the step size in the optimization algorithm, which may help to improve the convergence speed. Moreover, it is an attractive alternative to the heuristic choice of step size for diverse operating conditions. The disturbance as well as state estimates from the higher order sliding mode observer are utilized by the plant output prediction model, which will improve the overall performance of the controller. The nonlinear dynamics defined in leader fixed Euler-Hill frame has been considered for the present work and the reference trajectories are generated using Hill-Clohessy-Wiltshire equations of unperturbed motion. The simulation results based on rigorous perturbation analysis are presented to confirm the robustness of the proposed approach. | Ranjith Ravindranathan Nair Laxmidhar Behera | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 8 |
| 10 | 带有REV-LTR片段的MDV野毒株GX0101 BAC克隆的构建及拯救病毒的致病性分析显示文摘将整合有禽网状内皮组织增生症病毒(reticuloendotheliosis,REV)长末端重复序列(LTR)的马立克氏病病毒(命名为GX0101)全基因组作为细菌人工染色体(bacterial artificial chromosome,BAC)克隆进大肠杆菌.BAC载体通过同源重组插入MDV基因组的US2区,含BAC载体的MDV DNA电转化大肠杆菌菌株DH10B,鉴定含MDV全基因组的BAC克隆(MDV BAC),提取BAC DNA,转染原代鸡胚成纤维细胞(CEF),成功拯救出了重组病毒,命名为bac-GX0101.将此病毒腹腔接种1日龄鸡,在攻毒后62d开始检测到内脏肿瘤,动物实验结果表明,bac-GX0101毒株与亲本GX0101毒株对机体的致病性等方面的影响没有差异,bac-GX0101毒株仍然保留着很好的免疫抑制功能及致肿瘤能力.该感染性克隆bac-GX0101为研究该重组野毒株中REV-LTR插入片段及其他基因的生物学功能提供了有用的技术平台. | 孙爱军 PETHERBRIDGE Lawrence ZHAO YuGuang 李延鹏 NAIR Venugopal K 崔治中 | 2009 | 科学通报2009，54，11： | 7 |
| 11 | Metabolism, enzymology and possible roles of 4-aminobutyrie acid 显示文摘 | Satya Narayan V Nair P M | 1989 | Biochemistry1989，8，： | 7 |
| 12 | 肿瘤体积、厚度和T分类作为手术治疗舌鳞状细胞癌效果的预测因子显示文摘背景:根据TNM分类,在同一分类中具有良好预后的浅表肿瘤与深度浸润、预后不好的肿瘤常被混淆。方法:对588例未接受过治疗的舌癌患者进行回顾研究。使用肿瘤体积和厚度作为单独的模型,二元逻辑回归用于确定淋巴结转移和包膜外扩散(ECS)的预测价值。生成C指数以量化T分类、厚度和存活的肿瘤体积的预测准确性。 | Mair M Nair D Nair S 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，5： | 7 |
| 13 | Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations显示文摘AIM To characterize AXL receptor tyrosine kinase(AXL)expression in relationship to tumor protein P53(TP53gene,p53 protein)and its role in tumor invasion and response to therapy.METHODS We used 14 cell lines,including 3 isogenic pairs carrying mutant/knockout p53,to gain insight into the relationship between AXL and TP53.These included HCT116,HCT116.p53 mutant,RKO,and RKO.p53-/-lines(all from colon cancers)as well as breast cancer cell lines MCF7 and 1001(MCF7-p53 mutant clone).He La cell line was used as a positive control for epithelial to mesenchymal transition(EMT).AXL expression was determined by Western blotting using rabbit monoclonal antibody clone C89E7.AXL si RNA silencing was performed and followed by collagen invasion assay.Cell viability analysis using the sulforhodamine B assay and the invasion assay were performed after exposure to chemotherapeutic agents(doxorubicin for breast cancer cells;5FU or irinotecan for colon cancer cells).RESULTS We showed that the introduction of p53 mutations or knockout increased expression levels of AXL in isogenic cells compared to the matching p53 wild-type parental cells.Overall,we found a trend for correlation between the potential EMT candidate AXL,p53 alterations,and EMT markers in colorectal and breast cancers.The expression of AXL in RKO cells,a rare colon cancer cell line with inactive Wnt signaling,suggests that the AXL oncogene might provide an alternative genetic pathway for colorectal carcinogenesis in the absence of Wnt signaling activation and TP53 mutation.AXL silencing in the TP53 mutant isogenic cell lines 1001,HCT116.p53 mutant and RKO.P53-/-was>95%efficient and the silenced cells were less invasive compared to the parental TP53 wild-type cells.AXL silencing showed a subtle trend to restore colon cancer cell sensitivity to5FU or irinotecan.Importantly,AXL expressing cells developed more invasive potential after exposure to chemotherapy compared to the AXL-silenced cells.CONCLUSION AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy.These findings could have applications in cancer management. | Wael M Abdel-Rahman Noura A Al-khayyal Vidhya A Nair S R Aravind Maha Saber-Ayad | 2017 | World Journal of Gastroenterology2017，23，19： | 7 |
| 14 | An overview of the recent developments in polylactide (PLA) research显示文摘 | K. Madhavan Nampoothiri Nimisha Rajendran Nair Rojan Pappy John | 2010 | Bioresource Technology2010，，22： | 6 |
| 15 | An experimental study of elastic properties of dragonfly-like flapping wings for use in biomimetic micro air vehicles(BMAVs)显示文摘This article studies the elastic properties of several biomimetic micro air vehicle(BMAV)wings that are based on a dragonfly wing.BMAVs are a new class of unmanned micro-sized air vehicles that mimic the flapping wing motion of flying biological organisms(e.g.,insects,birds,and bats).Three structurally identical wings were fabricated using different materials:acrylonitrile butadiene styrene(ABS),polylactic acid(PLA),and acrylic.Simplified wing frame structures were fabricated from these materials and then a nanocomposite film was adhered to them which mimics the membrane of an actual dragonfly.These wings were then attached to an electromagnetic actuator and passively flapped at frequencies of 10-250 Hz.A three-dimensional high frame rate imaging system was used to capture the flapping motions of these wings at a resolution of 320 pixels x 240 pixels and 35000 frames per second.The maximum bending angle,maximum wing tip deflection,maximum wing tip twist angle,and wing tip twist speed of each wing were measured and compared to each other and the actual dragonfly wing.The results show that the ABS wing has considerable flexibility in the chordwise direction,whereas the PLA and acrylic wings show better conformity to an actual dragonfly wing in the spanwise direction.Past studies have shown that the aerodynamic performance of a BMAV flapping wing is enhanced if its chordwise flexibility is increased and its spanwise flexibility is reduced.Therefore,the ABS wing(fabricated using a 3D printer) shows the most promising results for future applications. | Praveena Nair Sivasankaran Thomas Arthur Ward Erfan Salami Rubentheren Viyapuri Christopher J.Fearday Mohd Rafie Johan | 2017 | Chinese Journal of Aeronautics2017，30，2： | 5 |
| 16 | Regulation of Nrf2- and AP-l-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells显示文摘 | Sujit NAIR Avantika BARVE Tin-Oo KHOR Guo-xiang SHEN Wen LIN Jefferson Y CHAN Li CAI Ah-Ng KONG | 2010 | Acta Pharmacologica Sinica2010，31，9： | 5 |
| 17 | Heavy Metal Accumulation in Medicinal Plants Collected from Environmentally Different Sites显示文摘Objective To estimate the heavy metal content in soil and selected medicinal plants procured from environmentally different sites of the same city. Methods Soil and plant samples of Abutilon indicum, Calotropis procera, Euphorbia hirta, Peristrophe bycaliculata, and Tinospora cordifolia were collected from 3 environmentally different sites of the city: heavy traffic area (HTA), industrial area (IA), and residential area (RA). Pb, Cd, Cr, and Ni were estimated in soil and plant samples by inductively coupled plasma emission spectrometry and compared. Results The level of heavy metal was higher in soil than in plant parts studied. Accumulation of heavy metals varied from plant to plant. Pb was the highest in Calotropis procera root from HTA site and the lowest in Peristrophe bycaliculata whole plant from IA site. It was also lower in residential area than in heavy traffic area. Conclusion The level of heavy metal content differed in the same medicinal plant collected from environmentally different sites of the same city. Thus, it reiterates our belief that every medicinal plant sample should be tested for contaminant load before processing it further for medication. | JYOTI BARTHWAL SMITHA NAIR POONAM KAKKAR | 2008 | Biomedical and Environmental Sciences2008，21，4： | 5 |
| 18 | Gas chromatography mass spectrometry based metabolic profiling reveals biomarkers involved in rice-gall midge interactions显示文摘The Asian rice gall midge(Orseolia oryzae WoodMason) is a serious pest of rice that causes huge loss in yield.While feeding inside the susceptible host,maggots secrete substances that facilitate the formation of a hollow tube-like structure called gall and prevent panicle formation.The present investigation was carried out to get an account of biochemical changes occurring in the rice plant upon gall midge feeding.Metabolic profiling of host tissues from three rice varieties,namely,TN1,Kavya,and RP2068,exposed to gall midge biotype 1(GMB1),was carried out using gas chromatography mass spectrometry(GC-MS).TN1 and GMB1 represented compatible interaction,while Kavya and GMB1 as well as RP2068 and GMB1 represented incompatible interactions.The current study identified several metabolites that could be grouped as resistance,susceptibility,infestation,and host features based on their relative abundance.These may be regarded as biomarkers for insect-plant interaction in general and rice-gall midge interaction in particular. | Ruchi Agarrwal Jagadish Sanmallappa Bentur Suresh Nair | 2014 | Journal of Integrative Plant Biology2014，56，9： | 5 |
| 19 | Tunable synthesis solid or hollow Au-Ag nanostructure, assembled with GO and comparative study of their catalytic properties显示文摘在这个工作,我们由调整 pH 作为种子与 Ag nanoparticles ( AgNPs )为 Ag@Au 核心壳 nanoparticles ( Ag@AuNPs )和 Ag/Au 空 nanocages ( Ag/AuNCs )的合成表明了一个简单、有效的二拍子的圆舞方法,并且混合 Ag@AuNPs-graphene 或 Ag/AuNCs-graphene 氧化物 nanocomposites (Ag@AuNPs去或 Ag/AuNCs-GO )的准备基于自己组装。它从静电的集会实验被注意 Ag/AuNCs 在上的装载数量去 nanosheet 多于 Ag@AuNPs 的。同样综合的混合材料被传播电子显微镜学描绘,原子力量显微镜学, -potential, 高角度的环形的黑暗地的扫描传播电子显微镜学, thermogravimetric 分析器和 X 光检查衍射。Ag@AuNPs, Ag/AuNCs 和 Ag/AuNCs-GO nanostructures 的催化活动在 4- , 3-nitrophenol 或 2-nitrophenol 的减小被调查到 4- , 3-aminophenol, 或 2-aminophenol,并且根据比较运动研究,下列趋势为相关催化活动被获得:Ag/AuNCs-GO ?>? Ag/AuNCs ?>? Ag@AuNPs。这些观察被归因于为混合 nanostructures 的催化反应和作文可得到的表面区域的同时的效果。 | Lidan Xu Min Hong Yongliang Wang Ming Li Haibo Li Madhavan P. N. Nair Chen-Zhong Li | 2016 | Science Bulletin2016，61，19： | 4 |
| 20 | Photoanode Activity of ZnO Nanotube Based Dye-Sensitized Solar Cells显示文摘Vertical ZnO nanotube (ZNT) arrays were synthesized onto an indium doped tin oxide (ITO) glass substrate by a simple electrochemical deposition technique followed by a selective etching process. Scanning electron microscopy (SEM) showed formation of well-faceted hexagonal ZNT arrays spreading uniformly over a largearea. X-ray diffraction (XRD) of ZNT layer showed substantially higher intensity for the (0002) diffractionpeak, indicating that the ZnO crystallites were well aligned with their c-axis. Profilometer measurements ofthe ZNT layer showed an average thickness of ~7 μm. Diameter size distribution (DSD) analysis showedthat ZNTs exhibited a narrow diameter size distribution in the range of 65–120 nm and centered at ~75nm. The photoluminescence (PL) spectrum measurement showed violet and blue luminescence peaks thatwere centered at 410 and 480 nm, respectively, indicating the presence of internal defects. Ultra-violet (UV)spectroscopy showed major absorbance peak at ~348 nm, exhibiting an increase in energy gap value of 3.4 eV.By employing the formed ZNTs as the photo-anode for a dye-sensitized solar cell (DSSC), a full-sun conversion efficiency of 1.01% was achieved with a fill factor of 54%. Quantum efficiency studies showed the maximumof incident photon-to-electron conversion efficiency in a visible region located at 520–550 nm range. | R. Ranjusha P. Lekha K.R.V. Subramanian V. Nair Shantikumar A. Balakrishnan | 2011 | Journal of Materials Science & Technology2011，27，11： | 4 |
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