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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | Variable breeding phenol- ogy affects theexposure of amphibian embryos to Ultraviolet radiation 显示文摘 | CORN P S MUTHS E | 2002 | Ecology2002，83，： | 1 |
| 3 | Cortisol levels predict motion sickness tolerance in women but not in men显示文摘 | Meissner K Enck P Muth E R | 2009 | Physiol Behav2009，97，1： | 1 |
| 4 | Gas embolism显示文摘 | Muth C M Shank E S | 2000 | N Eng J Med2000，342，： | 1 |
| 5 | The Ki67 index a prognostic marker in medullarythyroid carcinoma 显示文摘 | Tisell L E Oden A Muth A | 2003 | Br J Cancer2003，89，11： | 1 |
| 6 | Signitieance of autonomic nervous system activity in functional dyspepsia显示文摘 | Muth E R Koch K L Stern R M | 2000 | Dig Dis Sci2000，45，5： | 1 |
| 7 | Middle east respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: A comparative serological study显示文摘 | Reusken C B E M Haagmans B L Miiller M A Guti- errez C Godeke G-J Meyer B Muth D Raj V S Vries L S-D Corman V M Drexler J-F Smits S L E1 Tahir Y E De Sousa R van Beek J Nowotny N van Maanen K Hidalgo-Hermoso E Bosch B-J Rot- tier P Osterhaus A Gortdzar-Schmidt C Drosten C Koopmans M P G | 2013 | The Lan cet Infectious Diseases2013，13，10： | 1 |
| 8 | miR-9, a MYC/MYCN-activatcd microRNA, regulates E-cadherin and cancer metastasis 显示文摘 | Ma L Young J Prabhala H Pan E Mestdagh P Muth D | 2010 | Nat Cell Biol2010，12，3： | 1 |
| 9 | Antibodies against mers coronavirus in dromedary cam- els, united arab emirates, 2003 and 2013显示文摘 | Meyer B Muller M A Corman V M Reusken C B Ritz D Godeke G J Lattwein E Kallies S Siemens A van Beek J Drexler J F Muth D Bosch B J Wernery U Koopmans M P Wernery R Drosten C | 2014 | Emerg Infect Dis2014，20，4： | 1 |
| 10 | Conjugative plasmid transfer in Gram-positive bacteria显示文摘 | Grohmann E Muth G Espinosa M | 2003 | Microbiol Mol Biol Rev2003，67，： | 1 |
| 11 | Alkylation of Arenes with Benzylic and Propargylic Alcohols-Classical versus Fancy Catalysts显示文摘 | Liu J Muth E Florke U | | 0，，4： | 1 |
| 12 | The Ki67 index a prognostic marker in medullary thyroid carcinoma显示文摘 | TISELL L E ODEN A MUTH A | 2003 | Br J Cancer2003，89，11： | 1 |
| 13 | Efficient replica- tion of the novel human betacoronavirus EMC on primary hu- man epithelium highlights its zoonotic potential 显示文摘 | Kindler E Jonsdottir H R Muth D | 2013 | MBio2013，，00： | 1 |
| 14 | Gas embolism显示文摘 | MUTH C M SHANK E S | 2000 | N Engl JMed2000，342，7： | 1 |
| 15 | The effects of 28 hours of sleep deprivation on respiratory sinus arrhythmia during tasks with low and high controlled attention demands显示文摘 | WALKER A D MUTH E R ODLE-DUSSEAU H N | 2009 | Psychophysiology2009，46，1： | 1 |
| 16 | Learning effects in economic lot size显示文摘 | Muth E J Spremann K | 1983 | Management Science1983，29，2： | 1 |
| 17 | Multilevel Regression Mixture Analysis显示文摘 | Muth e n B Asparouhov T | 2009 | Journal of the Royal Statistical Society Series A2009，172，3： | 1 |
| 18 | The Ki67 index a prognostic marker in medullary thyroid carcinoma显示文摘 | Tisell L E Oden A Muth A | 2003 | Br J Cancer2003，89，11： | 1 |
| 19 | Effects of buffering conditions and culture pH on production rates and giycosylation of clinical phase I anti - melanoma mouse IgG3 monoclonal antibody R24 显示文摘 | Muthing J Kemminer S E Conradt H S | 2003 | Biotcchnology and Bioengineering2003，83，3： | 1 |
| 20 | Experimental results with selenium in white muscle disease of lambs and calves 显示文摘 | Muth O H Oldfield J E | 1961 | Fed Proc1961，20，： | 1 |
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