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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | Malignant pheo- chromocytoma in a population-based study: survival and clinical results显示文摘 | Wangberg B Muth A Khorram-Manesh A | 2006 | Ann N Y Acad Sci2006，1073，： | 1 |
| 3 | Prognostic factors for survival after surgery for adrenal metastasis显示文摘 | Muth A Persson F Jansson S | 2010 | Eur J Surg Oncol2010，36，： | 1 |
| 4 | MicroRNA regulation of cell lineages in mouse and human embryonic stem cells显示文摘 | Ivey K N Muth A Arnold J | 2008 | Cell Stem Cell2008，2，3： | 1 |
| 5 | Malignant pheochromocytoma in a population-based study: survival and clinical results显示文摘 | Wangberg B Muth A Khorram-Manesh A | 2006 | Ann N Y Aead Sci JT-Annals of the New York Academy of Sciences2006，1073，： | 1 |
| 6 | MicroRNA regulation of cell lineages in mouse and human embryonic stem cells显示文摘 | IVEY K N MUTH A ARNOLD J | 2008 | Cell Stem Cell2008，2，3： | 1 |
| 7 | Face recognition with symmetric local graph structure显示文摘 | ABDULL A H SAYEE D MUTH U | 2014 | MedSci2014，14，41： | 1 |
| 8 | miRNA regulation of cell lineages in mouse and human embrionic stem cells显示文摘 | Ivey KN Muth A Arnold J | 2008 | Cell Stem Cell2008，2，： | 1 |
| 9 | Optical and Structural Properties of Epitaxial Mgx Znt-x O Alloys显示文摘 | Sharma A K Narayan J Muth J F | 1999 | Appl Phys Lett1999，75，21： | 1 |
| 10 | MicroRNA regulation of cell lineages in mouse and human embryonic stem cells显示文摘 | Ivey KN Muth A ArnoldJ | 2008 | Cell Stem Cell2008，2，3： | 1 |
| 11 | Mutations in NOTCH1 cause aortic valve disease 显示文摘 | Vidu Garg Muth A N | 2010 | Nature2010，437，2： | 1 |
| 12 | Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC 显示文摘 | Raj VS Mou HH Smits SL Dekkers DH Mueller MA Dijkman R Muth DA Zaki A Fouchier RA Thiel V Drosten C Rottier PJ Osterhaus AD Bosch BJ Haagmans BL | 2013 | Nature2013，495，7440： | 1 |
| 13 | Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction 显示文摘 | Corman V M Eckerle I Bleicker T Zaki A Landt O Eschbach-Bludau M van Boheemen S Gopal R Ball- hause M Bestebroer T M Muth D Mtiller M A Drex-ler JF Zambon M Osterhaus A D Fouchier R M Drosten C | 2012 | Euro Surveill2012，17，39： | 1 |
| 14 | Optical and structural properties of expitaxial MgxZn1-x alloys显示文摘 | Sharma A K Narayan J Muth J F | 1999 | Appl Phys Lett1999，75，21： | 1 |
| 15 | Statins differ in their ability to block NF - kappa B activation in human blood monocytes 显示文摘 | Hilgendorff A Muth H Parviz B | 2003 | Int J Clin Pharmacol Ther2003，41，9： | 1 |
| 16 | Optical and structural properties of epitaxial MgxZn1-xO alloys 显示文摘 | Sharma A K Narayan J Muth J F | | Applied Physics Letters0，75，21： | 1 |
| 17 | The binding interaction of coomassie blue with proteins显示文摘 | GONGDON R W MUTH G W SPLITTGERBER A G | 1993 | Analytical Biochemistry1993，213，2： | 1 |
| 18 | Prognostic factors for survival after surgery for adrenal metastasis显示文摘 | Muth A Persson F Jansson S | | 0，，： | 1 |
| 19 | MicroRNA regulation o- cell lineages in mouse and human embryonic stem cells显示文摘 | Ivey KN Muth A Arnold J | 2008 | Cell Stem Cell2008，2，3： | 1 |
| 20 | MicroRNA regulation of cell lineages in mouse and human embryonic stem cells 显示文摘 | Ivey KN Muth A Arnold J | 2008 | Cell Stem Cell2008，2，3： | 1 |
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