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| 1 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | HER-2/neu amplification is highly homogenous in gastric cancer 显示文摘 | Marx AH Tharun l Muth J | 2009 | Human Pathology2009，40，6： | 1 |
| 3 | A dynamic programming algorithm for decision CPM networks显示文摘 | Hindelang T J Muth J F | 1979 | Operations Research1979，27，2： | 1 |
| 4 | Rational expectations and the theory of price movement显示文摘 | Muth J F | 1961 | Econometrica1961，29，6： | 1 |
| 5 | MicroRNA regulation of cell lineages in mouse and human embryonic stem cells显示文摘 | Ivey K N Muth A Arnold J | 2008 | Cell Stem Cell2008，2，3： | 1 |
| 6 | MicroRNA regulation of cell lineages in mouse and human embryonic stem cells显示文摘 | IVEY K N MUTH A ARNOLD J | 2008 | Cell Stem Cell2008，2，3： | 1 |
| 7 | Dielectric elastomer based prototype fiber actuators显示文摘 | Arora S Ghosh T Muth J | 2007 | Sensors and Actuators A:Physical2007，136，1： | 1 |
| 8 | miRNA regulation of cell lineages in mouse and human embrionic stem cells显示文摘 | Ivey KN Muth A Arnold J | 2008 | Cell Stem Cell2008，2，： | 1 |
| 9 | Optical and Structural Properties of Epitaxial Mgx Znt-x O Alloys显示文摘 | Sharma A K Narayan J Muth J F | 1999 | Appl Phys Lett1999，75，21： | 1 |
| 10 | Embedded 3D Printing of Strain Sensors within Highly Stretchab|e E|astomers 显示文摘 | MUTH J T ~OGT D M TRUBY R L | 2014 | Advanced Materials2014，26，36： | 1 |
| 11 | Refractive indices and adsorption coefficients of MgxZn1-x O alloys显示文摘 | Teng C W Muth J F Ozgur U | 2000 | Applied Physics Letters2000，76，8： | 1 |
| 12 | Her-2 amplification is highly homogenous in gastric cancer显示文摘 | Marx AH Tharun L Muth J | 2010 | Hum Pathol2010，41，2： | 1 |
| 13 | Optical and structural properties of expitaxial MgxZn1-x alloys显示文摘 | Sharma A K Narayan J Muth J F | 1999 | Appl Phys Lett1999，75，21： | 1 |
| 14 | Rational expectations and the theory of price movements 显示文摘 | Muth J F | 1961 | Econometrica1961，29，3： | 1 |
| 15 | Dominance of tunneling current and band filling in InGaN/AlGaN double heterostructure blue light-emitting diodes显示文摘 | Casey H C Muth J J Krishnankutty S | 1996 | Applied PhysicsLetter1996，68，： | 1 |
| 16 | Rational expectations and the theory of price movements 显示文摘 | Muth J F | 1961 | Econometric1961，29，3： | 1 |
| 17 | Refractive indices and ad-sorption coefficients of MgsZnj 0 alloys 显示文摘 | Teng C W Muth J F Ozgur U | 2000 | Appl PhysLett2000，76，8： | 1 |
| 18 | Optical and structural properties of epitaxial MgxZn1-xO alloys 显示文摘 | Sharma A K Narayan J Muth J F | | Applied Physics Letters0，75，21： | 1 |
| 19 | Rational Expectations and the Theory of Price Movements 显示文摘 | Muth J F | 1961 | Econometrica1961，28，29： | 1 |
| 20 | MicroRNA regulation o- cell lineages in mouse and human embryonic stem cells显示文摘 | Ivey KN Muth A Arnold J | 2008 | Cell Stem Cell2008，2，3： | 1 |
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