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| 1 | Neoadjuvant-intensified treatment for rectal cancer:Time to change?显示文摘AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patients with histologically confirmed rectal adenocarcinoma were enrolled.Tumors were clinically classified as either T3 or T4 and by the N stage based on the presence or absence of positive regional lymph nodes.Patients received intensified combined modality treatment,consisting of neoadjuvant radiation therapy(50.4-54.0 Gy) and infusional chemotherapy(oxaliplatin 50 mg/m 2) on the first day of each week,plus five daily continuous infusions of fluorouracil(200 mg/m 2 per die) from the first day of radiation therapy until radiotherapy completion.Patients received five or six cycles of oxaliplatin based on performance status,clinical lymph node involvement,and potential risk of a non-sphincter-conserving surgical procedure.Surgery was planned 7 to 9 wk after the end of radiochemotherapy treatment;adjuvant chemotherapy treatment was left to the oncologist's discretion and was recommended in patients with positive lymph nodes.After treatment,all patients were monitored every three months for the first year and every six months for the subsequent years.RESULTS:Of the 80 patients enrolled,75 patients completed the programmed neoadjuvant radiochemotherapy treatment.All patients received the radiotherapy prescribed total dose;five patients suspended chemotherapy indefinitely because of chemotherapyrelated toxicity.At least five cycles of oxaliplatin were administered to 73 patients.Treatment was well tolerated with high compliance and a good level of toxicity.Most of the acute toxic effects observed were classified as grades 1-2.Proctitis grade 2 was the most common symptom(63.75%) and the earliest manifestation of acute toxicity.Acute toxicity grades 3-4 was reported in 30% of patients and grade 3 or 4 diarrhoea reported in just three patients(3.75%).Seventy-seven patients underwent surgery;low anterior resection was performed in 52 patients,Miles' surgery in 11 patients and total mesorectal excision in nine patients.Fifty patients showed tumor downsizing ≥ 50% pathological downstaging in 88.00% of tumors.Out of 75 patients surviving surgery,67 patients(89.33%) had some form of downstaging after preoperative treatment.A pathological complete response was achieved in 23.75% of patients and a nearly pathologic complete response(stage ypT1ypN0) in six patients.An involvement of the radial margin was never present.During surgery,intra-abdominal metastases were found in only one patient(1.25%).Initially,45 patients required an abdominoperineal resection due to a tumor distal margin ≤ 5 cm from the anal verge.Of these patients,only seven of them underwent Miles' surgery and sphincter preservation was guaranteed in 84.50% of patients in this subgroup.Fourteen patients received postoperative chemotherapy.In the full analysis of enrolled cohort,eight of the 80 patients died,with seven deaths related to rectal cancer and one to unrelated causes.Local recurrences were observed in seven patients(8.75%) and distant metastases in 17 cases(21.25%).The fiveyear rate of overall survival rate was 90.91%.Using a median follow-up time of 28.5 mo,the cumulative incidence of local recurrences was 8.75%,and the overall survival and disease-free survival rates were 90.00% and 70.00%,respectively.CONCLUSION:The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival,likely due to an increase in local tumor control. | Daniela Musio Francesca De Felice Nadia Bulzonetti Roberta Guarnaccia Rossella Caiazzo Caterina Bangrazi Nicola Raffetto Vincenzo Tombolini | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 2 | Neoadjuvant chemoradiotherapy for locally advanced rectal cancer:The debate continues显示文摘Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a multimodality strategy approach, combining surgery, radiation therapy and chemotherapy. Nowadays, surgery remains the primary treatment and neoadjuvant chemoradiotherapy, based on fluoropyrimidine(5-FU) continuous infusion, is considered the standard in locally advanced rectal carcinoma. The aim is to reduce the incidence of local recurrence and to perform a conservative surgery. To improve these purposes different drugs combination have been tested in the neo-adjuvant setting. At American Society of Clinical Oncology 2014 an important abstract was presented focusing on the role of adding oxaliplatin to concomitant treatment, in patients with locally advanced rectal carcinoma. Rodel et al reported on the CAO/ARO/AIO-04 randomized phase Ⅲ trial that compared standard treatment with 5-FU and radiation therapy, to oxaliplatin plus 5-FU inassociation with radiation therapy. The addition of oxaliplatin to the neo-adjuvant treatment has been shown to improve disease-free survival from 71.2% to 75.9%(P = 0.03). This editorial was planned to clarify the optimal treatment in patients with locally advanced rectal cancer, considering the results from CAO/ARO/AIO-04 study. | Francesca De Felice Daniela Musio Luciano Izzo Vincenzo Tombolini | 2014 | World Journal of Gastrointestinal Oncology2014，6，12： | 5 |
| 3 | Chemoradiation as definitive treatment for primary squamous cell cancer of the rectum显示文摘In this report,we present a case of advanced squamous cell cancer located in the rectum of a 78-year-old woman treated with chemoradiation with curative intent.The patient showed a complete clinical response to chemoradiation;multiple biopsies were performed at the site of the previous mass 5 mo after the end of treatment and histological examination showed no residual tumour in the specimens.Surgical intervention was avoided and the patient was free of disease 12 mo after the diagnosis of cancer.Primary chemoradiation should be considered as the treatment of choice for this rare malignancy. | Eva Iannacone Francesco Dionisi Daniela Musio Rossella Caiazzo Nicola Raffetto Enzo Banelli | 2010 | World Journal of Radiology2010，2，8： | 2 |
| 4 | An unusual case of fatty liver in a patient with desmoid tumor显示文摘A desmoid tumor,also known as aggressive fibromatosis,is a rare benign neoplasm that arises from fascial or musculoaponeurotic tissues.It can occur in any anatomical location,most commonly the abdominal wall,shoulder girdle and retroperitoneum.The typical clinical presentation is a painless mass with a slow and progressive invasion of contiguous structures.It is associated with a high local recurrence rate after resection.Many issues regarding the optimal treatment of desmoid tumors remain controversial.Aggressive surgical resection with a wide margin(2-3 cm) remains the gold standard treatment with regard to preserving quality of life.Radiotherapy alone has been shown to be effective for the control of unresectable or recurrent lesions.Desmoid tumors tend to be locally infiltrative,therefore,the fields must be generous to prevent marginal recurrence.The radiation dose appropriate for treating desmoid tumors remains controversial.We present a 25-year-old Caucasian man with local recurrence of a desmoid tumor after repeated surgical resection,treated with radiotherapy.The patient achieved complete tumor regression at 4 mo after radiotherapy,and he is clinically free of disease at 12 mo after the end of treatment,with an acceptable quality of life.The patient developed short bowel syndrome as a complication of second surgical resection.Consequently,radiotherapy might have worsened an already present malabsorption and so led to steatohepatitis. | Francesca De Felice Daniela Musio Rossella Caiazzo Bartolomeo Dipalma Lavinia Grapulin Camilla Proietti Semproni Vincenzo Tombolini | 2012 | World Journal of Gastroenterology2012，18，24： | 2 |
| 5 | Enhanced expression of common fragile sites with occupational exposure to pesticides 显示文摘 | SBRANA I MUSIO A | 1995 | Cancer Genet Cytogenet1995，82，2： | 1 |
| 6 | Spontaneous and aphidicolin-sensitive fragilesite 3cen co-localizes with the (TTAGGG) telomeric sequence in Chinese hamster cells 显示文摘 | Musio A Rainaldi G sbrana I | 1996 | Cytogenetics and cell genetics1996，75，23： | 1 |
| 7 | Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP , ZWINT-1 and ZW10 genes显示文摘 | Antonio Musio Tullio Mariani Cristina Montagna Desirèe Zambroni Cesare Ascoli Thomas Ried Paolo Vezzoni | 2004 | Gene2004，，： | 1 |
| 8 | Review of thrombotic thrombocytopenic purpura in the setting of systemic lupus erythematosus 显示文摘 | Musio F Bohen EM Yuan CM | 1998 | Semin Arthritis Rheum1998，28，： | 1 |
| 9 | Preoperative intensified ra - diochemotherapy for rectal cancer: experience of a single institution显示文摘 | Dionisi F Musio D Raffetto N | 2011 | Int J Colorectal Dis2011，26，： | 1 |
| 10 | Detection of Taurine in Biological Tissues by 33 S NMR Spectroscopy显示文摘 | Roberta Musio Oronzo Sciacovelli | 2001 | Journal of Magnetic Resonance2001，，2： | 1 |
| 11 | Preoperative chemoradiotherapy in elderly patients with locally advanced rectal cancer显示文摘 | De Felice F Musio D Izzo L | 2013 | Biomed Res Int2013，2013，10： | 1 |
| 12 | Physiologic oxygen enhances human embryonic stem cell clonal recovery and reduces chromoso- mal abnormalities显示文摘 | Forsyth NR Musio A Vezzoni P | 2006 | Cloning Stem Cells2006，8，： | 1 |
| 13 | Physiologic oxygen enhances human embryonic stem cel clonal recovery and reduces chromosomal abnormalities显示文摘 | Forsyth NR Musio A Vezzoni P | | 0，，01： | 1 |
| 14 | Primed in situ labelling(PRINS) :a method for rapid identification and quantification of human chromosome in both lymphocytes and sperm nuclei显示文摘 | Musio A | 1998 | Genome1998，41，： | 1 |
| 15 | Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts显示文摘 | MONTAGNA C ZAMBRONI D | 2003 | Cancer Res2003，63，： | 1 |
| 16 | Inhibition of BuBI results in genomic in stability and anchorage-independent groath of normal human fibroblasts显示文摘 | MUSIO A MONYAGNAC ZAMBRONID | 2003 | Cancer Res2003，63，： | 1 |
| 17 | Preoperative intensified radiochemotherapy for rectal cancer: experience of a single institution 显示文摘 | Dionisi F Musio D Raffetto N | 2011 | Int J Colorectal Dis2011，26，2： | 1 |
| 18 | AC and DC measurements on Langmuir-Blodgett polypyrrolefilm for selective NH3 gas detection显示文摘 | PENZA M MILELLA E MUSIO F | 1998 | Mater Sci Eng C1998，5，34： | 1 |
| 19 | The dark side of cohesin:the carcinogenic point of view显示文摘 | Mannini L Musio A | 2011 | Mutat Res2011，728，： | 1 |
| 20 | Polypyrrole LB multilayer sensitive films for odorants显示文摘 | MILELLA E MUSIO F ALBA M B | 1996 | Thin Solid Films1996，，： | 1 |
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