|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rescue associating liver partition and portal vein ligation for staged hepatectomy after portal embolization: Our experience and literature review显示文摘AIM To report a single-center experience in rescue associating liver partition and portal vein ligation for staged hepatectomy(ALPPS), after failure of previous portal embolization. We also performed a literature review.METHODS Between January 2014 and December 2015, every patient who underwent a rescue ALPPS procedure in Toulouse Rangueil University Hospital, France, was included. Every patient included had a project of major hepatectomy and a previous portal vein embolization(PVE) with insufficient future liver remnant to body weight ratio after the procedure. The ALPPS procedure was performed in two steps(ALPPS-1 and ALPPS-2), separated by an interval phase. ALPPS-2 was done within 7 to 9 d after ALPPS-1. To estimate the FLR, a computed tomography scan examination was performed 3 to 6 wk after the PVE procedure and 6 to 8 d after ALPPS-1. A transcystic stent was placed during ALPPS-1 and remained opened duringthe interval phase, in order to avoid biliary complications. Postoperative liver failure was defined using the 50-50 criteria. Postoperative complications were assessed according to the Dindo-Clavien Classification.RESULTS From January 2014 to December 2015, 7 patients underwent a rescue ALPPS procedure. Median FLR before PVE, ALPPS-1 and ALPPS-2 were respectively 263 cc(221-380), 450 cc(372-506), and 660 cc(575-776). Median FLR/BWR before PVE, ALPPS-1 and ALPPS-2 were respectively 0.4%(0.3-0.5), 0.6%(0.5-0.8), and 1%(0.8-1.2). Median volume growth of FLR was 69%(18-92) after PVE, and 45%(36-82) after ALPPS-1. The combination of PVE and ALPPS induced a growth of median initial FLR of +408 cc(254-513), leading to an increase of +149%(68-199). After ALPPS-2, 4 patients had stage Ⅰ-Ⅱ complications. Three patients had more severe complications(one stage Ⅲ, one stage Ⅳ and one death due to bowel perforation). Two patients suffered from postoperative liver failure according to the 50/50 criteria. None of our patients developed any biliary complication during the ALPPS procedure.CONCLUSION Rescue ALPPS may be an alternative after unsuccessful PVE and could allow previously unresectable patients to reach surgery. Biliary drainage seems to reduce biliary complications. | Charlotte Maulat Antoine Philis Bérénice Charriere Fatima-Zohra Mokrane Rosine Guimbaud Philippe Otal Bertrand Suc Fabrice Muscari | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | High tacrolimus intra-patient variability is associated with graft rejection,and de novo donor-specific antibodies occurrence after liver transplantation显示文摘AIM To investigate the role of tacrolimus intra-patient variability(IPV) in adult liver-transplant recipients.METHODS We retrospectively assessed tacrolimus variability in a cohort of liver-transplant recipients and analyzed its effect on the occurrence of graft rejection and de novo donor-specific antibodies(dn DSAs), as well as graft survival during the first 2 years posttransplantation. Between 02/08 and 06/2015, 116 patients that received tacrolimus plus mycophenolate mofetil(with or without steroids) were included. RESULTS Twenty-two patients(18.5%) experienced at least one acute-rejection episode(BPAR). Predictive factors for a BPAR were a tacrolimus IPV of > 35% [OR = 3.07 95%CI(1.14-8.24), P = 0.03] or > 40% [OR = 4.16(1.38-12.50), P = 0.01), and a tacrolimus trough level of < 5 ng/mL [OR=3.68(1.3-10.4), P =0.014]. Thirteen patients(11.2%) developed at least one dn DSA during the follow-up. Tacrolimus IPV [coded as a continuous variable: OR = 1.1, 95%CI(1.0-1.12), P = 0.006] of > 35% [OR = 4.83, 95%CI(1.39-16.72), P = 0.01] and > 40% [OR = 9.73, 95%CI(2.65-35.76), P = 0.001] were identified as predictors to detect dn DSAs. IPV did not impact on patient-or graft-survival rates during the follow-up. CONCLUSION Tacrolimus-IPV could be a useful tool to identify patients with a greater risk of graft rejection and of developing a de novo DSA after liver | Arnaud Del Bello Nicolas Congy-Jolivet Marie Danjoux Fabrice Muscari Laurence Lavayssière Laure Esposito Anne-Laure Hebral Julie Bellière Nassim Kamar | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 3 | Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation显示文摘Acute humoral rejection (AHR) is uncommon after ABO-compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specif ic antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. She was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Liver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. She was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Liver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy. | Nassim Kamar Laurence Lavayssière Fabrice Muscari Janick Selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 4 | Marine propellers performance and flow-field prediction by a free-wake panel method显示文摘A Boundary Element Method(BEM) hydrodynamics combined with a flow-alignment technique to evaluate blades shed vorticity is presented and applied to a marine propeller in open water. Potentialities and drawbacks of this approach in capturing propeller performance, slipstream velocities, blade pressure distribution and pressure disturbance in the flow-field are highlighted by comparisons with available experiments and RANSE results. In particular, correlations between the shape of the convected vortexsheet and the accuracy of BEM results are discussed throughout the paper. To this aim, the analysis of propeller thrust and torque is the starting point towards a detailed discussion on the capability of a 3-D free-wake BEM hydrodynamic approach to describe the local features of the flow-field behind the propeller disk, in view of applications to propulsive configurations where the shed wake plays a dominant role. | GRECO Luca MUSCARI Roberto TESTA Claudio DI MASCIO Andrea | 2014 | Journal of Hydrodynamics2014，26，5： | 4 |
| 5 | Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy显示文摘BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological criteria.More recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor cells.AIM To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after NAC.METHODSFrom January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt TRG.Based on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were performed.RESULTS Seventy-four patients were classified as responders and 76 as non-responders.The postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological response.Three were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P <0.005). Two were predictive of a good response: A rectal origin of the primary tumor and a liver-first strategy(P < 0.005). The overall survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 yr.The factors contributing to a poor prognosis for disease-free survival were: No histological response after NAC, largest metastasis > 3 cm, more than three preoperative metastases, R1 resection, and the use of a targeted therapy with NAC(P < 0.005).CONCLUSION A non-radiological response and a number of NAC sessions > 7 are the two most pertinent predictive factors of non-histological response(TRG 4 or 5). | Chloé Serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane Janick Selves Rosine Guimbaud Philippe Otal Bertrand Suc Emilie Berard Fabrice Muscari | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 4 |
| 6 | Contribution of alpha-fetoprotein in liver transplantation for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP) is the main tumor biomarker available for the management of hepatocellular carcinoma(HCC). Although it is neither a good screening test nor an accurate diagnostic tool for HCC, it seems to be a possible prognostic marker. However, its contribution in liver transplantation for HCC has not been fully determined, although its use to predict recurrence after liver transplantation has been underlined by international societies. In an era of organ shortages, it could also have a key role in the selection of patients eligible for liver transplantation. Yet unanswered questions remain. First, the cut-off value of serum AFP above which liver transplantation should not be performed is still a subject of debate. We show that a concentration of 1000 ng/m L could be an exclusion criterion, whereas values of < 15 ng/m L indicate patients with an excellent prognosis whatever the size and number of tumors. Monitoring the dynamics of AFP could also prove useful. However, evidence is lacking regarding the values that should be used. Today, the real input of AFP seems to be its integration into new criteria to select patients eligible for a liver transplantation. These recent tools have associated AFP values with morphological criteria, thus refining pre-existing criteria, such as Milan, University of California, San Francisco, or 'up-to-seven'. We provide a review of the different criteria submitted within the past years. Finally, AFP can be used to monitor recurrence after transplantation, although there is little evidence to support this claim. Future challenges will be to draft new international guidelines to implement the use of AFP as a selection tool, and to determine a clear cut-off value above which liver transplantation should not be performed. | Bérénice Charrière Charlotte Maulat Bertrand Suc Fabrice Muscari | 2016 | World Journal of Hepatology2016，8，21： | 3 |
| 7 | Carotid lesions in outpatients with nonalcoholic fatty liver disease显示文摘AIM:To ascertain whether carotid lesions are more prevalent in outpatients with incidental findings of nonalcoholic fatty liver disease (NAFLD) at abdominal ultrasound (US).METHODS: One hundred and fifty-four consecutive outpatients (age range 24-90 years, both sexes) referred by general practitioners for abdominal US, and drinking less than 20 g alcohol/day, underwent carotid US for an assessment of carotid intima-media thickness (c-IMT) and carotid plaque prevalence. Hepatic steatosis, visceral fat thickness and subcutaneous fat thickness were also assessed at ultrasonography.RESULTS: Higher c-IMT values were found in the presence of NAFLD (90 patients), even after adjustment for indices of general and abdominal obesity and for the principal cardiovascular risk factors (0.84±0.10 mm vs 0.71±0.10 mm, P<0.001). The prevalence of carotid plaques was 57.8% in the patients with NAFLD vs 37.5% in the patients without this condition (P=0.02). The adjusted relative risk of having carotid plaques for patients with NAFLD was 1.85 (95% CI:1.33-2.57, P<0.001).CONCLUSION: An incidental finding of hepatic steatosis may suggest the presence of silent carotid atherosclerotic lesions. | Stefano Ramilli Stefano Pretolani Antonio Muscari Barbara Pacelli Vincenzo Arienti | 2009 | World Journal of Gastroenterology2009，15，38： | 3 |
| 8 | Adhesive Postoperative Small Bowel Obstruction: Incidence and Risk Factors of Recurrence After Surgical Treatment: A Multicenter Prospective Study显示文摘 | Jean-Jacques Duron Nathalie Jourdan-Da Silva Sophie Tezenas du Montcel Anne Berger Fabrice Muscari Henri Hennet Michel Veyrieres Jean Marie Hay | 2006 | Annals of Surgery2006，，5： | 2 |
| 9 | The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications显示文摘 | Paolo Puddu Giovanni M. Puddu Eleonora Cravero Luca Vizioli Antonio Muscari | 2012 | Journal of Cardiology2012，，3： | 2 |
| 10 | Safety of Liver Resection for Hepatocellular Carcinoma After Sorafenib Therapy: A Multicenter Case-Matched Study显示文摘 | Louise Barbier David Fuks Patrick Pessaux Fabrice Muscari Yves-Patrice Treut Sandrine Faivre Jacques Belghiti | 2013 | Annals of Surgical Oncology2013，，11： | 2 |
| 11 | Orthotopic Liver Transplantation with Vena Cava Preservation in Cirrhotic Patients:is Systematic Temporary Portacaval Anastomosis a Justified Procedure?显示文摘 | MUSCARI F SUC B AGUIRRE J | 2005 | Transplant Proc2005，37，2： | 1 |
| 12 | The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases 显示文摘 | Vizioli L Muscari S Muscari A | 2009 | Int J Clin Pratt2009，63，10： | 1 |
| 13 | The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases显示文摘 | Vizioli L Muscari S Muscari A | 2009 | Int J Clin Pract2009，63，10： | 1 |
| 14 | Determinants of mean platelet volume (MPV)in an elderly population: relevance of body fat,blood glucose and isehaemic electrocardiographic chan- ges 显示文摘 | Muscari A De Pasealis S Cenni A | 2008 | Thromb Haemost2008，99，： | 1 |
| 15 | Predictive factors for posttransplant diabetes mellitus within one-year of liver transplantation 显示文摘 | Oufroukhi L Kamar N Muscari F | 2008 | Transplantation2008，85，10： | 1 |
| 16 | Evaluation of nitric oxiderelease in the coronary effluent by a novel EPR technique: astudy on isolated rat hearts subjected to cold cardioplegia andreperfusion显示文摘 | Muscari C Grossi L Giordano E | 2003 | Life Sci2003，74，1： | 1 |
| 17 | Different associations of C-reactive protein, fibrinogen and C3 with traditional risk factors in middle-aged men 显示文摘 | Muscari A Bastagli L Poggiopollini G | 2002 | Int J Cardiol2002，83，： | 1 |
| 18 | The relationship of mean plateletvolume with the risk and prognosis of cardiovascular diseases显示文摘 | Vizioli L Muscari S Muscari A | 2009 | International Journal of Clinical Practice2009，63，10： | 1 |
| 19 | Modeling of vortex dynamics in the wake of a marine propeller显示文摘 | MUSCARI R DI MASCIO A VERZICCO R | 2013 | Computers & Fluids2013，73，6： | 1 |
| 20 | On the wake dynamics of a propeller operating in drift显示文摘 | DI MASCIO A MUSCARI R DUBBIOSO G | 2014 | Journal of Fluid Mechanics2014，754，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员