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| 1 | Pattern response of dendritic cells in the tumor microenvironment and breast cancer显示文摘Breast cancer(BC) is the most common malignant neoplasm and the cause of death by cancer among women worldwide. Its development, including malignancy grade and patient prognosis, is influenced by various mutations that occur in the tumor cell and by the immune system's status, which has a direct influence on the tumor microenvironment and, consequently, on interactions with non-tumor cells involved in the immunological response. Among the immune response cells, dendritic cells(DCs) play a key role in the induction and maintenance of anti-tumor responses owing to their unique abilities for antigen cross-presentation and promotion of the activation of specific lymphocytes that target neoplasic cells. However, the tumor microenvironment can polarize DCs, transforming them into immunosuppressive regulatory DCs, a tolerogenicphenotype which limits the activity of effector T cells and supports tumor growth and progression. Various factors and signaling pathways have been implicated in the immunosuppressive functioning of DCs in cancer, and researchers are working on resolving processes that can circumvent tumor escape and developing viable therapeutic interventions to prevent or reverse the expression of immunosuppressive DCs in the tumor microenvironment. A better understanding of the pattern of DC response in patients with BC is fundamental to the development of specific therapeutic approaches to enable DCs to function properly. Various studies examining DCs immunotherapy have demonstrated its great potential for inducing immune responses to specific antigens and thereby reversing immunosuppression and related to clinical response in patients with BC. DCbased immunotherapy research has led to immense scientific advances, both in our understanding of the antitumor immune response and for the treatment of these patients. | Alessandra da Cunha Marcia A Michelin Eddie FC Murta | 2014 | World Journal of Clinical Oncology2014，5，3： | 5 |
| 2 | 一总线在北京谱仪实验模型BESⅢ Slow Control中的应用显示文摘介绍了北京正负电子对撞机国家重点工程中,BESⅢS low Con tro l在全新北京谱仪中的重要性,并对通过在三个探测器:M uon RPC、量能器EM C、漂移室M DC实验模型中的具体实例应用,介绍了慢控制主要采用的一总线技术。 | 谢小希 谢嵩 高翠山 聂振东 张银鸿 陈锡辉 刘国明 高路 谢一冈 Fabrizio Murtas Paolo Valente | 2005 | 核电子学与探测技术2005，25，5： | 2 |
| 3 | Application of ductus venosus Doppler velocimetry for the detection of fetal aneuploidy in the first trimester of pregnancy显示文摘 | Murta CG Moron AF Avila MA Weiner CP | 2002 | Fetal Diagn Ther2002，17，： | 1 |
| 4 | Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox 显示文摘 | MURTA S M GAZZINELLI R T BRENER Z etal | 1998 | Mol Biochem Parasitol1998，93，2： | 1 |
| 5 | Clinical significance of a negative loop electrosurgical excision procedure, conization and hysterectomy for cervical intraepithelial neoplasia显示文摘 | Murta EF Silva AO Silva EA | 2006 | Eur J Gynaecol Oncol2006，27，1： | 1 |
| 6 | Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade Ⅲ 显示文摘 | Terra AP Murta EF Maluf PJ | 2007 | Tumori2007，93，： | 1 |
| 7 | Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P glycoprotein ( PGP ) genes显示文摘 | MURTA S M DOS SANTOS W G ANACLETO C | 2001 | Mol Biochem Parasitol2001，117，2： | 1 |
| 8 | Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade IU 显示文摘 | TERRA AP MURTA EF MALUF PJ | 2007 | Tumori2007，93，6： | 1 |
| 9 | Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade Ⅲ显示文摘 | Terra AP Murta EF Maluf PJ | 2007 | Tumori2007，93，： | 1 |
| 10 | Colorectal cancer survival: results from a hospital- based cancer registry显示文摘 | Aguero F Murta - Nascimento C Gallen M | 2012 | Rev Esp Erferm Dig2012，104，： | 1 |
| 11 | Clinical significance of nega- tive loop electrosurgical excision procedure, coniation and hys- terectomy for cervical intraepithelial neoplasia显示文摘 | Murta EF Silva AO Silva EA | 2010 | Gynecol Oncol2010，100，2： | 1 |
| 12 | Ovarian clear cell carcinoma associated with endometriosis: a case report with immunohistochemical study显示文摘 | Murta EF Nomelini RS Ferreira FA | 2007 | Eur J Gynaecol Oncol2007，28，5： | 1 |
| 13 | Direct characterization of target podocyte antigens and autoantibodies in human membranous glomerulonephritis:alpha-enolase and borderline antigens显示文摘 | Bruschi M Camevali M L Murtas C | | 0，，10： | 1 |
| 14 | In vivo characterization of renal auto-antigens involved in human autoimmune diseases:The case of membranous glomerulonephritis显示文摘 | Murtas C Bruschi M Camevali M L | | 0，，1： | 1 |
| 15 | Vaginal in- traepithelial neoplasia: clinical-therapeutic analysis of 33 cases 显示文摘 | Murta EF Neves Junior MA Sempionato LR | 2005 | Arch Gynecol Obstet2005，272，4： | 1 |
| 16 | Outcome after conization for cervical intraepitheial neoplaaia graⅢ:relation with surgical margins,extension to the crypts and mitoses显示文摘 | Maluf PJ Adad SJ Murta EF | 2004 | Tumori2004，90，5： | 1 |
| 17 | A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates显示文摘 | Murtas G Reeves PH Fu YF Bancroft I Dean C Coup-land G | | 0，，10： | 1 |
| 18 | Olinical significance of a negative loop electrosurgical excision procedure,conization and hysterectomy for cervical intraepithelial neoplasia显示文摘 | Murta EF Silva AO Silva EA | 2006 | Eur J Gynaecol Oncol2006，27，1： | 1 |
| 19 | Vaginal intraepithelial neoplasia: clinical-therapeutic analysis of 33 cases显示文摘 | Murta EF Neves Junior MA Sempionato LR | 2005 | Arch Gynecol Obstet2005，272，4： | 1 |
| 20 | Outcome alter eonlzation for cervical intraepitheial neoplasia grade Ⅲ : relation with surgical margins, extension to the crypts and mitoses显示文摘 | Maluf PJ Adad SJ Murta EF | 2004 | Tumori2004，90，5： | 1 |
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