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| 1 | 聚乙二醇电解质散剂联合二甲硅油在结肠镜检查肠道准备中的应用效果观察显示文摘目的:探讨聚乙二醇电解质散剂(PEG)联合二甲硅油在结肠镜检查肠道准备中的应用效果。方法:行结肠镜检查的患者238例,随机分为研究组(聚乙二醇电解质散剂联合二甲硅油组)和对照组(甘露醇组),比较两种肠道准备方法在肠道清洁度、祛泡效果、耐受性、息肉检出率、术后腹胀程度方面的差异。结果:最终210例符合条件入组,纳入统计分析,210例患者均完成肠道准备和全结肠镜检查。与对照组相比,研究组肠道清洁度满意率为90.29%、祛泡效果满意率为98.05%、息肉检出率为18.45%均优于对照组,两组比较差异具有统计学意义(P<0.05);而研究组不良反应发生率、排便次数、术后腹胀发生率与对照组比较差异无统计学意义(P>0.05)。结论:PEG联合二甲硅油在结肠镜检查肠道准备中的效果优于传统肠道清洁剂甘露醇,患者安全性和耐受性较高,有利于改善视野,提高病变检出率,尤其是微小息肉及扁平息肉的检出率。 | 张淑芬 薛挥 李建宏 高梦琪 张拉 Muna Palikhe | 2020 | 陕西医学杂志2020，49，2： | 27 |
| 2 | 利用欧拉反褶积法估计二度磁性体深度与位置显示文摘为了利用欧拉反褶积进行快速计算,提出了多个大小不同的滑动窗口进行多次覆盖的算法,对高精度磁测剖面逐点反复计算,并根据统计学原理从大量计算结果中剔除坏解,保留合理的解;还根据2D模型讨论了结构指数与欧拉反褶积的结果的关系。将该方法应用于我国西北某地区的高精度航磁资料处理,获得较好的地质效果。 | 史辉 刘天佑 Dawi Muna Ghaboush | 2005 | 物探与化探2005，29，3： | 26 |
| 3 | Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease显示文摘Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ 25-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer's disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume,while Ellman method showed significant decrease in the activity of acetylcholinesterase in all three regions (prefrontal cortex,medial septum and hippocampus). These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer's disease. | Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin Jong-Il Park Kyu-Sik Jo Bo-Hee Lee Soo-Wan Chae Sun-Young Kim Soo-Hyun Park Eun-Ock Park Eun-Kyung Choi Young-Chul Chung | 2013 | Neural Regeneration Research2013，8，12： | 21 |
| 4 | Transjugular intrahepatic portosystemic shunt vs endoscopic therapy in preventing variceal rebleeding显示文摘AIM:To compare early use of transjugular intrahepatic portosystemic shunt(TIPS) with endoscopic treatment(ET) for the prophylaxis of recurrent variceal bleeding.METHODS:In-patient data were collected from 190 patients between January 2007 and June 2010 who suffured from variceal bleeding.Patients who were older than 75 years;previously received surgical treatment or endoscopic therapy for variceal bleeding;and complicated with hepatic encephalopathy or hepatic cancer,were excluded from this research.Thirty-five cases lost to follow-up were also excluded.Retrospective analysis was done in 126 eligible cases.Among them,64 patients received TIPS(TIPS group) while 62 patients received endoscopic therapy(ET group).The relevant data were collected by patient review or telephone calls.The occurrence of rebleeding,hepatic encephalopathy or other complications,survival rateand cost of treatment were compared between the two groups.RESULTS:During the follow-up period(median,20.7 and 18.7 mo in TIPS and ET groups,respectively),rebleeding from any source occurred in 11 patients in the TIPS group as compared with 31 patients in the ET group(Kaplan-Meier analysis and log-rank test,P = 0.000).Rebleeding rates at any time point(6 wk,1 year and 2 year) in the TIPS group were lower than in the ET group(Bonferroni correction α' = α/3).Eight patients in the TIPS group and 16 in the ET group died with the cumulative survival rates of 80.6% and 64.9%(Kaplan-Meier analysis and log-rank test c2 = 4.864,P = 0.02),respectively.There was no significant difference between the two groups with respect to 6-wk survival rates(Bonferroni correction α' = α/3).However,significant differences were observed between the two groups in the 1-year survival rates(92% and 79%) and the 2-year survival rates(89% and 64.9%)(Bonferroni correction α' = α/3).No significant differences were observed between the two treatment groups in the occurrence of hepatic encephalopathy(12 patients in TIPS group and 5 in ET group,KaplanMeier analysis and log-rank test,c2 = 3.103,P = 0.08).The average total cost for the TIPS group was higher than for ET group(Wilcxon-Mann Whitney test,52 678 RMB vs 38 844 RMB,P < 0.05),but hospitalization frequency and hospital stay during follow-up period were lower(Wilcxon-Mann Whitney test,0.4 d vs 1.3 d,P = 0.01;5 d vs 19 d,P < 0.05).CONCLUSION:Early use of TIPS is more effective than endoscopic treatment in preventing variceal rebleeding and improving survival rate,and does not increase occurrence of hepatic encephalopathy. | Hui Xue Meng Zhang Jack XQ Pang Fei Yan Ying-Chao Li Liang-Shan Lv Jia Yuan Muna Palikhe Wei-Zhi Li Zhi-Lun Wang | 2012 | World Journal of Gastroenterology2012，18，48： | 17 |
| 5 | Dysregulation of gastric H,K-ATPase by cigarette smoke extract显示文摘AIM:To test whether the expression and activity of H,K-ATPase in parietal cells would be affected by cigarette smoke extract.METHODS: Extracts of cigarette smoke were administered into mice by gastric gavage (5 mg/kg body weight/day) for 3 d or in drinking water for 7 or 14 d. For the latter, each day a mouse consumed 5 mL water containing extracts of two cigarettes, on average. Control littermate mice received only vehicle. To compare the amount of H,K-ATPase in control and smoke-treated mice, the stomach was processed for Western blotting and immunohistochemical analysis using monoclonal antibodies specific for α- or β-subunits of H,K-ATPase. The p-nitrophenylphospatase activity assay was used as a measurement for K-dependent H,K-ATPase activity.RESULTS: Probed transblots showed an increase in the amount of H,K-ATPase in smoke-treated mice which was confirmed by immunohistochemistry and was found to be due to increased amounts of protein per parietal cell rather than an increased parietal cell number. The increase in the amount of H,K-ATPase was associated with an enhancement of its enzymatic activity. K-dependent activity in control and smoke-treated mice was significantly different (respectively, 0.12 μmol/mg vs 0.27 μmol/mg per minute, P<0.05).CONCLUSION: Administration of cigarette smoke extract is associated with an increase in the amount and activity of H,K-ATPase and hence, smokers are susceptible to development of peptic ulcer. | Muna Hammadi Mohamed Adi Rony John Ghalia AK Khoder Sherif M Karam | 2009 | World Journal of Gastroenterology2009，15，32： | 7 |
| 6 | Endophytes as Producers of Peptides:An Overview About the Recently Discovered Peptides from Endophytic Microbes显示文摘An endophyte is a fungus or bacterium that lives within a plant in a symbiotic relationship.Extensive colonization of the plant tissue by endophytes creates a barrier effect,where they outcompete and prevent pathogenic organisms from taking hold.This happens by producing secondary metabolites that inhibit the growth of the competitors or pathogens.In this way they play a very important role in the plant defence mechanisms.The metabolites produced by these endophytes fall within a wide range of classes of compounds that include peptides which are the focus of this review.Peptides are increasingly being selected for drug development because they are specific for their targets and have a higher degree of interactions.There have been quite a number of endophytic peptides reported in the recent past indicating that endophytes can be used for the production of peptide based drugs.Molecular screening for NRPS,which shows peptide producing capability,has also shown that endophytes are potential producers of peptides.The presence of NRPS also offers the possibility of genetic modifications which may generate peptides with high pharmacological activities.This review,therefore,aims to show the current status of peptides isolated from endophytic bacteria and fungi in the recent decade.Endophytes as potential sources of peptides according to NRPS studies will also be discussed. | Muna Ali Abdalla Josphat C.Matasyoh | 2014 | Natural Products and Bioprospecting2014，4，5： | 5 |
| 7 | 尼泊尔喜马拉雅地区塔玛科什3级水电工程--穿越软弱构造片岩修建隧洞所面临的挑战显示文摘由于尼泊尔喜马拉雅地区岩石强度较低,水平应力较高,因此在该软弱构造片岩带中开挖隧洞具有较大的挑战性。文章主要阐述装机容量为650 kW的塔玛科什3级水电工程17km长大跨度隧洞和大型地下发电厂房(这两项工程计划穿越夹杂有软弱构造片岩带的坚硬眼球状片麻岩区域)所面临的重大技术挑战。穿过片岩带开挖的隧洞长度约占总长的15%,由于此岩层带岩石强度较低,具有剪切特性和渗流现象,且水平应力较高,围岩挤压和隧洞塌方都是可预期的问题,因此该工程地下开挖主要关注的问题是大尺寸隧洞的可施工性和工期。为了解决可预期问题,进行了更进一步的研究,主要集中在隧洞最大可建尺寸、方位、减少围岩挤压的开挖方法,以及地下发电厂房稳定性和合理岩石支护设计上。研究发现,在构造片岩带中可施工的全断面隧洞最大尺寸可达9m,为改进的马蹄形(有弧形仰拱)。通过对隧洞三种不同方位方案(即正交、斜交、平行)的分析发现,与叶理面正交的方案最佳,可减少围岩挤压近50%。 | Subas Chandra Sunuwar Sandip Shah Ashish Subedi Muna Sharma | 2013 | 现代隧道技术2013，50，1： | 3 |
| 8 | Understanding microstructure and mechanical properties of(AlTa(0.76))xCoCrFeNi(2.1) eutectic high entropy alloys via thermo-physical parameters显示文摘(AlTa(0.76))xCoCrFeNi(2.1)(x values in molar ratio,x=0.1,0.3,0.5,0.7,1.0,and 1.5) alloys were designed to investigate the microstructure and mechanical properties of the eutectic high entropy alloys(EHEAs)consisting of FCC,B2,and Laves phases.Depending on the compositional variatio,clear microstructural variation was observed,as follows:(1) Group 1:FCC dendrite+Laves interdendrite(x=0.1),(2) Group 2:FCC dendrite+fine-eutectic structure consisting of FCC and Laves phases(x=0.3,0.5 and 0.7),(3) Group 3:B2 dendrite+bimodal eutectic structure [FCC/B2+Laves](x=1.0),(4) Group 4:Laves dendrite+eutectic structure consisting of B2 and Laves phases(x=1.5).As the fraction of Laves or B2 phases increases,yield stress increases from 293 to 2336 MPa,while the plastic strain decreases from 50 % to 2%.Thermo-physical parameters,such as mixing entropy(△S(mix)),mixing enthalpy(△H(mix)),valence electron concentration(VEC),and atomic size difference(δr),were calculated to understand the microstructural variation.Two criteria(δr-VEC and δr-△H(mix)) were utilized to elucidate the formation of the eutectic structures in the present EHEAs,revealing the usefulness of the thermo-physical parameters in the development of EHEAs. | Min Jung Kim Gyeol Chan Kang Sung Hwan Hong Hae Jin Park Sang Chul Muna Gian Song Ki Buem Kim | 2020 | Journal of Materials Science & Technology2020，54，22： | 3 |
| 9 | Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach显示文摘Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. However, the translation into clinical practice has been largely unsuccessful and the compounds failed when were tested in clinical trials. This might be explained, at least partially, by the enormous complexity of the disease both from clinico-epidemiological and a pathogenic points of view. In this review, we will briefly comment on the complexity of the disease focusing on some recent findings, and we will suggest how amyotrophic lateral sclerosis research might be reoriented to foster the advance in the diagnostic and therapeutic questions. | Javier Riancho Francisco J.Gil-Bea Ana Santurtun Adolfo López de Munaín | 2019 | Neural Regeneration Research2019，14，2： | 2 |
| 10 | Stevens-Johnson syndrome complicating adalimumab therapy in Crohn's disease显示文摘The anti-tumor necrosis factor(TNF)αmedications demonstrate efficacy in the induction of remission and its maintenance in numerous chronic inflammatory conditions.With the increasing number of patients receiving anti-TNFαagents,however,less common adverse reactions will occur.Cutaneous eruptions complicating treatment with an anti-TNFαagent are not uncommon,occurring in around 20%of patients. Adalimumab,a fully humanized antibody against TNFα, may be expected to cause minimal immune-mediated skin reactions compared to the chimeric monoclonal antibody,infliximab.We,however,report a case of Stevens-Johnson syndrome that required hospitalization and cessation of adalimumab in a patient with Crohn’ s disease(CD).In this case report,a 29-year-old male with colonic and perianal CD with associated erythema nodosum and large joint arthropathy developed severe mucositis,peripheral rash and desquamation,fevers and respiratory symptoms concomitant with a second dose of 40 mg adalimumab after a 2 mo break from adalimumab therapy.Skin biopsies of the abdominal wall confirmed erythema multiforme and the patient was on no other drugs and infective etiologies were excluded.The patient responded rapidly to IV hydrocortisone and was able to be commenced on infliximab without recurrence of the Stevens-Johnson syndrome.Desquamating skin reactions have now been described in three of the TNFαantagonists(infliximab,etanercept and adalimumab).These reactions can be serious and prescribers need to be aware of the potential mucocutaneous side effects of these agents,especially as Stevens-Johnson syndrome is associated with significant morbidity and mortality. | Muna Salama Ian Craig Lawrance | 2009 | World Journal of Gastroenterology2009，15，35： | 2 |
| 11 | 均分直槽微结构光纤光栅磁场传感器显示文摘对微结构光纤磁场传感器的增敏性能进行研究,设计了一种基于飞秒激光微加工的均分直槽型微结构光纤磁场传感器。利用飞秒激光在刻有光纤布拉格光栅(FBG)的单模光纤(SMF)包层上刻蚀均分直槽微结构,并采用HF溶液清除直槽内的残留碎屑和应力集中点,随后用磁控溅射技术在加工部位溅射一层磁致伸缩薄膜TbDyFe。当外界磁场强度变化时,通过观测传感器中心波长的变化可实现对磁场强度的测量。直槽微结构能减小光纤横截面积,改善光纤轴向伸缩性能,增大薄膜附着表面积,从而提高传感器探头灵敏度。理论分析了直槽微结构提高传感器性能的工作原理,介绍了传感器探头的制备工艺和性能影响因素,给出了不同参数传感探头的磁场测试结果。实验结果表明,利用飞秒激光加工直槽微结构能明显改善传感器探头灵敏度,其中直槽个数对性能影响最为明显;相对于无微结构传感器探头,有微结构光纤探头灵敏度最高可提升3.8倍。 | 刘斌 戴玉堂 周贤 邹猛 Joseph Muna Karanja | 2015 | 光电子.激光2015，26，10： | 2 |
| 12 | Red fluorescent protein (DsRed2), an ideal reporter for cotton genetic transformation and molecular breeding显示文摘Genes encoding reporter proteins are used as visual marker-assisted tools in genetic transformation as well as plant breeding. In this study, the red fluorescent protein identified in Discosoma sp. coral(DsRed2) was successfully used as a visual marker for cotton genetic engineering. DsRed2 was successfully expressed in two cotton cultivars,JIN668 and YZ1, driven by the Ca MV-35 S promoter via the Agrobacterium-mediated transformation. Our results suggest that DsRed2 expression provides an early-stage selection tool for the transgenic calli via visual observation. Red fluorescence can be detected not only in callus and somatic embryos but also in most tissues and organs of mature plants. The transgenic line Yz-2-DsRed2 was crossed with four different cotton cultivars to assess the transgene heritability and stability in different genetic backgrounds.The heritability of the red color was highly stable when Yz-2-DsRed2 was used as a male parent. The DsRed2 gene expressed 100% in the F_1 hybrids. To investigate the relationship between DsRed2 transcription and DNA methylation, a methylation-specific PCR approach was applied to the Ca MV-35 S promoter region. The results showed a negative association between DNA methylation level in the promoter region and the transgene transcription.Taken together, these findings suggest DsRed2 a visual reporter gene for cotton genetic transformation and molecular breeding programs. | Lin Sun Muna Alariqi Yi Zhu Jianying Li Zelin Li Qing Wang Yajun Li Hangping Rui Xianlong Zhang Shuangxia Jin | 2018 | The Crop Journal2018，6，4： | 2 |
| 13 | Development of reduced-fat mayonnaise using 4aGTase-modified rice starch and xanthan gum显示文摘 | Saehun Muna Young-Lim Kima Choon-Gil Kangb | 2009 | International Journal of Biological Maeromoleeules2009，，44： | 1 |
| 14 | Omicron targets upper airways in pediatrics,elderly and unvaccinated population显示文摘Omicron,a severe acute respiratory syndrome coronavirus-2 variant,has spread around the globe,causing dramatic increases in infection rates.Viral mutant antigens were responsible for the strong infectivity,fast replication,and high reinfection rates reported from all ages.Omicron causes clinical symptoms mostly related to the upper respiratory tract with minimal symptoms from the lower respiratory tract besides an urgent presentation of cases that resembled a fatal illness,epiglottitis.Not to mention the long coronavirus disease 2019,which rises exponentially in the Omicrons era.Apparently,the disease has a less aggressive course than earlier variants with lower death rates;however,the infection is not trivial.Severe infection was raised among pediatrics,unvaccinated,and the elderly.Complete vaccine protection is urgently needed to protect the most vulnerable community members.Additionally,self-protective strategies such as wearing a mask and safe social distancing cannot be omitted. | Wassan Nori Muna Abdul Ghani Zghair | 2022 | World Journal of Clinical Cases2022，10，32： | 1 |
| 15 | A parallel genetic local search algorithm for intrusion detection in computer networks显示文摘 | Mohammad Saniee Abadeh Jafar Habibi Zeynab Barzegar Muna Sergi | 2007 | Engineering Applications of Artificial Intelligence2007，20，8： | 1 |
| 16 | A parallel genetic local search algorithm for intrusion detec- tion in computer networks显示文摘 | Mohammad Saniee Abadeh Jafar Habibi Zeynab Barzegar Muna Sergi | 2007 | Engineering Applications of Artifi- cial Intelligence2007，20，8： | 1 |
| 17 | 电化传感器设计显示文摘本文介绍了电化传感器的工作方式及原理,并据此探讨电化传感设计中应注意的一些关键问题。 | Muna Acosta | 2009 | 电子设计应用2009，，1： | 1 |
| 18 | Systemic Therapy With Conventional and Novel Immunomodulatory Agents for Ocular Inflammatory Disease显示文摘 | Khayyam Durrani Fouad R. Zakka Muna Ahmed Mohiuddin Memon Sana S. Siddique C. Stephen Foster | 2011 | Survey of Ophthalmology2011，，6： | 1 |
| 19 | The state of health in the Arab world,1990-2010:an analysis of the burden of diseases,injuries,and risk factors显示文摘 | AliH Mokdad Sara Jaber Muna I Abdel Aziz | | 0，，： | 1 |
| 20 | Aquatic toxicity from pulp and paper mill effluents: a review显示文摘 | Muna Ali Sreekrishnan T R | 2001 | Advances in Environmental Research2001，1，： | 1 |
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