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| 1 | Sphincter preservation for distal rectal cancer - a goal worth achieving at all costs?显示文摘To assess the merits of currently available treatment options in the management of patients with low rectal cancer, a review of the medical literature pertaining to the operative and non-operative management of low rectal cancer was performed, with particular emphasis on sphincter preservation, oncological outcome, functional outcome, morbidity, quality of life, and patient preference. Low anterior resection (AR) is technically feasible in an increasing proportion of patients with low rectal cancer. The cost of sphincter preservation is the risk of morbidity and poor functional outcome in a significant proportion of patients. Transanal and endoscopic surgery are attractive options in selected patients that can provide satisfactory oncological outcomes while avoiding the morbidity and functional sequelae of open total mesorectal excision. In complete responders to neo-adjuvant chemoradiotherapy, a non-operative approach may prove to be an option. Abdominoperineal excision (APE) imposes a permanent stoma and is associated with significant incidence of perineal morbidity but avoids the risk of poor functional outcome following AR. Quality of life following AR and APE is comparable. Given the choice, most patients will choose AR over APE, however patients following APE positively appraise this option. In striving toward sphincter preservation the challenge is not only to achieve the best possible oncological outcome, but also to ensure that patients with low rectal cancer have realistic and accurate expectations of their treatment choice so that the best possible overall outcome can be obtained by each individual. | Jürgen Mulsow Des C Winter | 2011 | World Journal of Gastroenterology2011，17，7： | 2 |
| 2 | Sentinel lymph nodemapping in colorectal cancer 显示文摘 | Mulsow J Winter DC O' Keane JC | 2003 | Br J Surg2003，90，6： | 1 |
| 3 | Multilevel factors influencing maternal stress during the first three years 显示文摘 | Mulsow M Caldera YM Pursley M | 2002 | Journal of Marriage & Family2002，64，4： | 1 |
| 4 | Sentinel lymph node mapping in colorectal cancer显示文摘 | Mulsow J Winter DC 0 'Keane JC | 2003 | Br J Surg2003，90，6： | 1 |
| 5 | Biotur- bation and porosity gradients显示文摘 | MULSOW S BOUDREAU B P SMITH J N | 1998 | Limnology and Oce- anography1998，43，： | 1 |
| 6 | Fibrogenesis in Crohn's disease显示文摘 | Burke JP Mulsow J J O'Keane C | 2007 | Am J Gastroenterol2007，102，2： | 1 |
| 7 | Cadmium bioaccumulation and retention kinetics in the Chilean blue mussel Mytilus chilensi s: Seawater and food exposure pathways显示文摘 | Pedro Hervé-Fernández Fanny Houlbrèque Florence Boisson Sandor Mulsow Jean-Louis Teyssié Fran?ois Oberha?nsli Sabine Azemard Ross Jeffree | 2010 | Aquatic Toxicology2010，，4： | 1 |
| 8 | Fibrogenesis in Crohn's disease显示文摘 | Burke JP Mulsow J J O' Keane C | 2007 | Am J Gaslroenterol2007，102，2： | 1 |
| 9 | Fibrogenesis in Crohn's disease显示文摘 | Burke JP Mulsow JJ O'Keane C | 2007 | Am J Gastroenterol2007，102，2： | 1 |
| 10 | Thorium isotopes as tracers of particles dynamics and deep dynamics and deep water circulation in Indian sector of the Southern Ocean (ANTARES Ⅳ) 显示文摘 | Coppola L Roy-Barman M Mulsow S | 2006 | Marine Chemistry2006，100，： | 1 |
| 11 | Sentinel lymph node mapping in colorectal cancer显示文摘 | Mulsow J Winter DC O'Keane JC | 2003 | Br J Surg2003，90，6： | 1 |
| 12 | Low par-ticulate organic carbon export in the frontal zone of the Southernocean(Indian sector)revealed by 234Th显示文摘 | COPPOLA L ROY-BANNAN M MULSOW S | 2005 | Deep-seaResearchⅠ2005，52，： | 1 |
| 13 | Aerial audiograms of several california sea lions and steller sea lions measured using single and multiple simultaneous auditory steady-state response methods显示文摘 | Mulsow J Reichmuth C Gulland F | 2011 | J Exp Biol2011，214，7： | 1 |
| 14 | Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen aetivated protein kinase cell signaling显示文摘 | Mulsow JJ Watson RW Fitzpatrick JM | 2005 | Ann Surg2005，242，6： | 1 |
| 15 | Expression and regulation of connective tissue growth factor by transforming growth factor beta and turnout necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease显示文摘 | Beddy D Mulsow J Watson RW | 2006 | Br J Surg2006，93，10： | 1 |
| 16 | Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn' s disease显示文摘 | Beddy D Mulsow J Watson R W | 2006 | Br J Surg2006，93，10： | 1 |
| 17 | Transforming growth factor-beta promotes profibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling 显示文摘 | Mulsow JJ Watson RW Fitzpatrick JM | 2005 | Ann Surg2005，242，6： | 1 |
| 18 | Extralevator abdominoperineal resection for low rectal cancer: new direction or miles behind? 显示文摘 | Mulsow J Winter DC | 2010 | Arch Surg2010，145，9： | 1 |
| 19 | There is no meaningful relationship between television exposure and symptoms of attention-deficit/hyperactivity disorder显示文摘 | Stevens T Mulsow M | | 0，，： | 1 |
| 20 | Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumor necrosis factor alpha in fibroblasts isolated fzom strictures in patients with Crohn' s disease显示文摘 | Beddy D Mulsow J Watson R W | 2006 | Br J Surg2006，93，10： | 1 |
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