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| 1 | Biosynthesis and molecular engineering of templated natural products显示文摘Bioactive small molecules that are produced by living organisms, often referred to as natural products(NPs), historically play a critical role in the context of both medicinal chemistry and chemical biology. How nature creates these chemical entities with stunning structural complexity and diversity using a limited range of simple substrates has not been fully understood. Focusing on two types of NPs that share a highly evolvable ‘template'-biosynthetic logic, we here provide specific examples to highlight the conceptual and technological leaps in NP biosynthesis and witness the area of progress since the beginning of the twenty-first century. The biosynthesis of polyketides, non-ribosomal peptides and their hybrids that share an assembly-line enzymology of modular multifunctional proteins exemplifies an extended ‘central dogma'that correlates the genotype of catalysts with the chemotype of products; in parallel, post-translational modifications of ribosomally synthesized peptides involve a number of unusual biochemical mechanisms for molecular maturation. Understanding the biosynthetic processes of these templated NPs would largely facilitate the design, development and utilization of compatible biosynthetic machineries to address the challenge that often arises from structural complexity to the accessibility and efficiency of current chemical synthesis. | Ming Chen Jingyu Liu Panpan Duan Mulin Li Wen Liu | 2017 | National Science Review2017，4，4： | 4 |
| 2 | Angular distribution of terahertz emission from laser interactions with solid targets显示文摘Intense femtosecond laser-plasma interactions can produce high power terahertz radiations.In our experiment,the polished copper target was irradiated by a p-polarized laser with intensity of more than 1018 W/cm2 at an incident angle of 67.5 from the target normal.The THz energy from three dierent detection angles is measured.The maximum emission is found in the direction at an angle of 45 to the laser backward direction,which is more than one order of magnitude higher than in the other two directions.A simple theoretical model has been established to explain the measurements. | DU Fei LI Chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi GE XuLei LI YuTong MA JingLong LIU XiaoLong ZHANG Lu SHENG ZhengMing CHEN LiMing LU Xin DONG QuanLi WANG ZhaoHua WEI ZhiYi ZHANG Jie | 2012 | Science China(Information Sciences)2012，55，1： | 2 |
| 3 | Effects of laser-plasma interactions on terahertz radiation from solid targets irradiated by ultrashort intense laser pulses显示文摘 | Chun Li Mulin Zhou Wenjun Ding | | PHYSICAL REVIEI VE 201 I0，84，03： | 1 |
| 4 | Role of resonance absorption in terahertz radiation generation from solid targets显示文摘 | Chun Li Yunqian Cui Mulin Zhou | 2014 | OPTICS EXPRESS2014，22，11： | 1 |
| 5 | Patch-based topic model for group detection显示文摘Pedestrians in crowd scenes tend to connect with each other and form coherent groups. In order to investigate the collective behaviors in crowds, plenty of studies have been conducted on group detection.However, most of the existing methods are limited to discover the underlying semantic priors of individuals. By segmenting the crowd image into patches, this paper proposes the Patch-based Topic Model(PTM) for group detection. The main contributions of this study are threefold:(1) the crowd dynamics are represented by patchlevel descriptor, which provides a macroscopic-level representation;(2) the semantic topic label of each patch are inferred by integrating the Latent Dirichlet Allocation(LDA) model and the Markov Random Fields(MRF);(3) the optimal group number is determined automatically with an intro-class distance evaluation criterion.Experimental results on real-world crowd videos demonstrate the superior performance of the proposed method over the state-of-the-arts. | Mulin CHEN Qi WANG Xuelong LI | 2017 | Science China(Information Sciences)2017，60，11： | 1 |
| 6 | Nanostructural ZnO based coplanar gas sensor arrays from the injection of metal chloride solutions: Device processing, gas-sensingproperties and selectivity in liquors applications显示文摘 | Li Can Zhang Shunping Hu Mulin | 2011 | Sensors and Actuators B: Chemical2011，53，2： | 1 |
| 7 | Inducible CRISPRa screen identifies putative enhancers显示文摘Enhancers are critical cis-regulatory elements that regulate spatiotemporal gene expression and control cell fates.However,the identification of enhancers in native cellular contexts still remains a challenge.Here,we develop an inducible CRISPR activation(CRISPRa)system by transgenic expression of doxycycline(Dox)-inducible dCas9-VPR in mouse embryonic stem cells(iVPR ESC).With this line,a simple introduction of specific guide RNAs targeting promoters or enhancers allows us to realize the effect of CRISPRa in an inducible,reversible,and Dox concentration-dependent manner.Taking advantage of this system,we induce tiled CRISPRa across genomic regions(105 kilobases)surrounding T(Brachyury),one of the key mesodermal development regulator genes.Moreover,we identify several CRISPRa-responsive elements with chromatin features of putative enhancers,including a region the homologous sequence in which humans harbors a body height risk variant.Genetic deletion of this region in ESC does affect subsequent T gene activation and osteogenic differentiation.Therefore,our inducible CRISPRa ESC line provides a convenient platform for high-throughput screens of putative enhancers. | Zhongye Dai Rui Li Yuying Hou Qian Li Ke Zhao Ting Li Mulin Jun Li Xudong Wu | 2021 | Journal of Genetics and Genomics2021，48，10： | 1 |
| 8 | GWASdb: a datab- ase for human genetic variants identified by genome-wide association studies显示文摘 | Mulin Jun Li Panwen Wang Xiaorong Liu | 2012 | NAR2012，40，1： | 1 |
| 9 | Polarization of terahertz emission out of incident plane from laser interactions with solid targets显示文摘A powerful terahertz(THz) pulse was produced by a p-polarized,70 fs,800 nm laser interacting with solid targets at an incident angle of 45°.The polarization of the THz emission was measured out of the laser incident plane.The results showed that it was linearly polarized.We established a surface current model to explain this phenomenon,assuming that the transient current moving along the plasma surface was responsible for the generation of the THz emission.The model expectation and the experimental result were in good agreement. | DU Fei LI Chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi LI YuTong MA JingLong SHENG ZhengMing CHEN LiMing LU Xin WANG ZhaoHua WEI ZhiYi ZHANG Jie | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 1 |
| 10 | Coagulation factors and the incidence of COVID-19 severity:Mendelian randomization analyses and supporting evidence显示文摘Dear Editor,The evolving pandemic of coronavirus disease 19(COVID-19),is arousing alarm to public health.According to epidemiological and observational investigations,coagulopathy was frequently seen in severe COVID-19 patients1.Some coagulation factors such as D-dimer,prothrombin time(PT);von Willebrand factor(VWF),platelet count,and fibrinogen were documented to be important predictors of critically ill patients with COVID-19 in many retrospective observational studies and were substantially discussed before(see Supplementary Notes),yet the causality from specific coagulation factors to the incidence of COVID-19 severity and the underlying mechanism remains elusive. | Yao Zhou Xinyi Qian Zipeng Liu Hongxi Yang Tong Liu Kexin Chen Yaogang Wang Pak Chung Sham Ying Yu Mulin Jun Li | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
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