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| 1 | 微生物次生代谢产物的生物合成显示文摘来源于微生物的次生代谢产物是新药发现和发展的重要源泉,也是行之有效、研究生物学问题的探针工具。微生物产生次生代谢产物的目的并非为人类所用,而是以之为工具或媒介,调控其内在的生物化学过程并响应各种外部环境的变化。另一方面,微生物也通过其产物的结构改变、优化和最终选择,适应各种动态、可变的生物学过程。化学结构与生物功能的共进化,体现了自然中小分子基于普适性与特异性的演变规律。围绕微生物次生代谢产物的生物合成机制,《微生物学通报》本期推出的《微生物天然产物发现及生物合成主题刊》包括16篇论文,内容涵盖了天然产物相关的化学结构、生物学功能、合成代谢途径、酶促反应机理、生物信息学分析等多个方面。期望该主题刊的出版有助于加强我国相关领域专家之间的交流与合作,促进微生物生物化学方向的学科发展。 | 刘文 | 2021 | 微生物学通报2021，48，7： | 4 |
| 2 | 合成化学的研究前沿和发展趋势显示文摘合成化学是研究物质创造与转化的学科,它是化学科学的基础和核心,是人类认识物质、创造物质的重要途径和手段。合成化学的突破不仅仅影响化学科学自身的快速发展,对其他科学,例如生命、材料、信息等科学的发展也起着重要的推动和促进作用。本文根据国家自然科学基金委员会第219期双清论坛'合成化学的极限'相关研讨内容撰写,在总结现代合成化学的研究进展、发展趋势和前沿领域的基础上,结合我国在该领域的研究现状及面临的问题和挑战,凝练出我国合成化学亟待发展的重要研究领域,探讨了未来需重点关注的科学问题和建议重点资助的研究方向。 | 康强 曹晓宇 刘磊 李鹏飞 吴长征 杨鹏 崔琳 陈拥军 | 2020 | 中国科学基金2020，34，3： | 3 |
| 3 | Biosynthesis of the Central Piperidine Nitrogen Heterocycle in Series a Thiopeptides显示文摘Summary of main observation and conclusion Thiopeptides,arising from complex posttranslational modifications of a genetically encoded precursor peptide,are of great interest due to their structural complexity and important biological activities.All of these antibiotics share a macrocyclic peptidyl core that contains a central,six-membered nitrogen heterocycle and are classified into five series a-e based on the oxidation state of the central nitrogenous ring.Here,we report that the biosynthesis of the central piperidine heterocycle of series a thiopeptides relies on the activity of homologues of an F420H2-dependent reductase TppX4 by exploiting and characterizing the piperidine-containing thiopeptin biosynthetic gene (tpp)cluster in Streptomyces tateyamensis.In vitro reconstruction of TppX4 activity demonstrated that the piperidine heterocycle of thiopeptins was transformed from a dehydropiperidine heterocycle,and TppX4 tolerated the changes in the C-termini and macrocyclic peptidyl core of substrate and also tolerated dehyropiperidine-containing monocyclic or bicyclic thiopeptides.The identification of TppX4 and its substrate tolerance enriches the biosynthetic toolbox for development of additional thiopeptide analogs for clinical drug screening. | Jingyu Liu Zhi Lin Hua Chen Heng Guo Jiang Tao Wen Liu | 2019 | Chinese Journal of Chemistry2019，37，1： | 2 |
| 4 | Discovery of New Thioviridamide-Like Compounds with Antitumor Activities显示文摘Thioviridamide is a structurally unique compound with potent antitumor activity.The biosynthesis of thioviridamide follows a typical pathway as ribosomally synthesized and post-transiationally modified peptides,making the genome mining-based discovery of thioviridamide-like compounds rational.Taking advantage of the linkage between the precursor peptide and the metabolite skeleton,we identified a new biosynthetic gene cluster in Streptomyces sp.NRRL S-87 that could encode thioviridamide analogues.Overexpression of the whole gene cluster led to the isolation and structure elucidation of TVA-YJ-4 and TVA-YJ-5,two novel thioviridamide-like compounds featuring N-terminal capping groups.Chemical screening of the fermentation extracts also detected TVA-YJ-6,another new thioviridamide-like compound with representative methionine sulfoxide.Detailed analysis further revealed that these structural modifications were introduced during the compound extraction process instead of through genuine enzymatic reactions.TVA-YJ-4 and TVA-YJ-5 display slightly reduced cytotoxic activities against a panel of tumor cell lines in comparison with their parental natural product,TVA-YJ-2.Our work will expand the membership of this rare class of compounds and promote related biosynthetic studies. | Yuqing Li Jingyu Liu Haoyu Tang Yanping Qiu Dandan Chen Wen Liu | 2019 | Chinese Journal of Chemistry2019，37，10： | 1 |
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