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| 1 | Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C显示文摘AIM: To elucidate risk factors contributing to the development of hepatocellular carcinoma (HCC) among patients with sustained viral response (SVR) after interferon (IFN) treatment and to examine whether HCV-RNA still remained in the liver of SVR patients who developed HCC. METHODS: Two-hundred and sixty-six patients, who achieved SVR, were enrolled in this study. We retrospectively reviewed clinical, viral and histological features of the patients, and examined whether the development of HCC depends on several clinical variables using Kaplan-Meier Method. RT-PCR was used to seek HCV-RNA in 3 out of 7 patients in whom liver tissue was available for molecular analysis. RESULTS: Among the enrolled 266 patients with SVR, HCC developed in 7 patients (7/266; 2.6%). We failed to detect HCV-RNA both in cancer and non-cancerous liver tissue in all three patients. The cumulative incidence for HCC was significantly different depending on hepatic fibrosis (F3-4) (P = 0.0028), hepatic steatosis (Grade 2-3) (P = 0.0002) and age (≥ 55) (P = 0.021) at the pre-interferon treatment. CONCLUSION: The current study demonstrated that age, hepatic fibrosis, and hepatic steatosis at pre- interferon treatment might be risk factors for developing HCC after SVR. | Atsushi Tanaka Satoko Uegaki Hiroko Kurihara Kiyoshi Aida Masaki Mikami Ikuo Nagashima Junji Shiga Hajime Takikawa | 2007 | World Journal of Gastroenterology2007，13，39： | 12 |
| 2 | Micro RNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6显示文摘AIM: To investigate the microR NA(miR NA) expression during histological progression from colorectal normal mucosa through adenoma to carcinoma within a lesion. METHODS: Using microarray, the sequential changes in miR NA expression profiles were compared in colonic lesions from matched samples; histologically, nonneoplastic mucosa, adenoma, and submucosal invasive carcinoma were microdissected from a tissue sample. Cell proliferation assay was performed to observe the effect of miR NA, and its target genes were predicted using bioinformatics approaches and the expression profile of SW480 transfected with the miR NA mimics. mR NA and protein levels of the target gene in colon cancer cell lines with a mimic control or miR NA mimics were measured using qR TPCR and Western blotting. The expression levels of miR NA and target gene in colorectal tissue samples were also measured.RESULTS: Microarray analysis identified that the miR-320 family, including miR-320 a, miR-320 b, miR-320 c, miR-320 d and miR-320 e, were differentially expressed in adenomaand submucosal invasive carcinoma. The mi R-320 family, which inhibits cell proliferation, is frequently downregulated in colorectal adenoma and submucosal invasive carcinoma tissues. Seven genes including CDK6 were identified to be common in the results of gene expression array and bioinformatics analyses performed to find the target gene of the miR-320 family. We confirmed that mR NA and protein levels of CDK6 were significantly suppressed in colon cancer cell lines with miR-320 family mimics. CDK6 expression was found to increase from non-neoplastic mucosa through adenoma to submucosal invasive carcinoma tissues and showed an inverse correlation with miR-320 family expression.CONCLUSION: MiR-320 family affects colorectal tumor proliferation by targeting CDK6, plays important role in its growth, and is considered to be a biomarker for its early detection. | Toshihiro Tadano Yoichi Kakuta Shin Hamada Yosuke Shimodaira Masatake Kuroha Yoko Kawakami Tomoya Kimura Hisashi Shiga Katsuya Endo Atsushi Masamune Seiichi Takahashi Yoshitaka Kinouchi Tooru Shimosegawa | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 9 |
| 3 | Cetuximab and panitumumab in a patient with colon cancer and concomitant chronic skin disease:A potential beneficial effect on psoriasis vulgaris显示文摘Monoclonal antibodies against epidermal growth factor receptor(EGFR) are used in the treatment of advanced colorectal cancer. However, these agents can induce severe dermatological side effects that discourage their administration in patients with chronic dermatological disease. EGFR plays a key role in normal skin development and immunological function, and is expressed in various tissues and organs, although contrarily, it is overexpressed in psoriasis-related skin lesions. Thus, discussion is ongoing regarding the putative pathological role and therapeutic potential of this protein. We herein report on a patient with advanced colon cancer and concomitant long-standing psoriasis vulgaris who received antiEGFR antibody monotherapy as a third-line treatment for metastatic disease. One week after the initiation of treatment, the patient's skin lesions dramatically subsided and the improvement was sustained during therapy. Based on this case, we propose that anti-EGFR antibody therapy is not necessarily contraindicated in patients with psoriasis vulgaris. Moreover, the findings reaffirmed that EGFR is an important molecule in the pathology of psoriasis. | Ken Okamoto Hiromichi Maeda Takeo Shiga Mai Shiga Ken Dabanaka Kazuhiro Hanazaki Michiya Kobayashi | 2015 | World Journal of Gastroenterology2015，21，12： | 4 |
| 4 | Short and long-term outcomes of endoscopic balloon dilatation for Crohn's disease strictures显示文摘AIM:To investigate the short and long-term outcomes of endoscopic balloon dilatation(EBD) for Crohn's disease(CD) strictures.METHODS:Between January 1995 and December 2011,47 EBD procedures were performed in 30 patients(8 females and 22 males) with CD.All patients had strictures through which an endoscope could not pass,and symptoms of these strictures included abdominal pain,abdominal fullness,nausea,and/or vomiting.The 47 strictures included 17 anastomotic and 30 de novo strictures.Endoscopy and dilatation were performed under conscious sedation with intravenous diazepam or flunitrazepam.The dilatations were all performed using through-the-scope balloons with diameters from 8 mm to 20 mm on inflation and lengths of 30-80 mm.Each dilatation session consisted of two to four,3-min multistep inflations of the balloon,repeated at intervals of 1 wk until adequate dilatation(up to 15-20 mm in diameter) was achieved.The follow-up data were collected from medical records and analyzed retrospectively.Primary success was defined as passage of the scope through the stricture after EBD.Longterm outcomes were analyzed focusing on interventionfree survival and surgery-free survival demonstrated by the Kaplan-Meier method.(Intervention-free meant cases in which neither endoscopic balloon re-dilatation nor surgery was needed after the first dilatation during the observation period).The log rank test was used to evaluate the difference in long-term outcomes between anastomotic and de novo stricture cases.RESULTS:Primary success was achieved in 44 of the 47 strictures(93.6%).Balloon dilatations failed in 3 cases(6.4%).In 1 case,EBD was a technical failure because the guide-wire could not be passed through the stricture which showed severe adhesion and was a flexural lesion of the intestine.In 2 cases,unexpected perforations occurred immediately after balloon dilatation.Of the 47 treatments,complications occurred in 5(10.6%).All 5 patients had de novo strictures.One suffered bleeding,two high fever and there were colorectal perforations.One of the patients with a colorectal perforation was treated surgically,the other was managed conservatively.These 2 cases correspond to the two aforementioned EBD failures.Long-term outcomes were evaluated for the 44 successfully-treated strictures after a median follow-up of 26 mo(range,2-172 mo).During the observation period,re-strictures after EBDs occurred in 26 cases(60.5%).Fourteen of these 26 re-stricture cases underwent EBD again,but in two EBD failed and surgery was ultimately performed in both cases.Twelve of the 26 re-stricture cases were initially treated surgically when the re-strictures occurred.Finally,30 of the 47 strictures(63.8%) were successfully managed with EBD,allowing surgery to be avoided.Intervention-free survival evaluated by the Kaplan-Meier method was 75% at 12 mo,58% at 24 mo,and 43% at 36 mo.There was no significant difference between the anastomotic strictures(n = 16) and de novo strictures(n = 28) in the intervention-free survival as evaluated by the log-rank test.Surgery-free survival evaluated by the Kaplan-Meier method was 90% at 12 mo,75% at 24 mo,and 53% at 36 mo.The 16 anastomotic strictures were associated with significantly better surgery-free survivals than the 28 de novo strictures(log-rank test:P < 0.05).CONCLUSION:Anastomotic strictures were associated with better long-term outcomes than de novo strictures,indicating that stricture type might be useful for predicting the long-term outcomes of EBD. | Katsuya Endo Seiichi Takahashi Hisashi Shiga Yoichi Kakuta Yoshitaka Kinouchi Tooru Shimosegawa | 2013 | World Journal of Gastroenterology2013，19，1： | 3 |
| 5 | Computed tomography of sinonasal non-Hodgkin lymphoma显示文摘 | Kondo M Hashimoto T Shiga H | 1984 | J Comput Assist Tomogr1984，8，2： | 2 |
| 6 | Mossbauer study of invartype iron-nickel alloy显示文摘 | Nakamura Y Shiga M | 1964 | J Phys Society JPN1964，19，： | 2 |
| 7 | Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatment显示文摘 | K. Ikeda Y. Shiga A. Takahashi T. Kai H. Kimura K. Takeyama H. Noji K. Ogawa A. Nakamura H. Ohira Y. Sato Y. Maruyama | 2006 | Leukemia & Lymphoma2006，，1： | 2 |
| 8 | Hepatoblastoma in a dog显示文摘 | Atsushi SHIGA Kinji SHIROTA Takuo SHIDA | 1997 | Vet Med Sci1997，59，12： | 1 |
| 9 | A CMOSbandgap voltage reference circuit with sub-l-V opera-tion显示文摘 | Banba H? Shiga H Umezawa A | 1999 | J Solid-State Circuits1999，34，5： | 1 |
| 10 | Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1显示文摘 | Shiga A Nozaki H Yokoseki A | | 0，，： | 1 |
| 11 | Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand:a prospective,randomized,double-blind,vehicle-controlled,dose-finding study in Japanese adult surgical patients显示文摘 | Fujii Y Shiga Y | | 0，，05： | 1 |
| 12 | The max-min Delphi Method and Fuzzy Dslphi Method Via Fuzzy Integration显示文摘 | Ishikawa A Amagasa M Shiga T Tomizawa G Tatsuta R Mieno H | 1993 | Fuzzy Sets and Systems1993，，5： | 1 |
| 13 | CSF hypovolemia vs intracranial hypotension in 'spontaneous intracranial hypotension syndrome'显示文摘 | Miyazawa K Shiga Y Hasegawa T | 2003 | Neurology2003，60，： | 1 |
| 14 | Computed tomography of sinonasal non-Hodgkin lymphoma显示文摘 | Kondo M Hashimoto T Shiga H | 1984 | J Comput Assist Tomogr1984，8，2： | 1 |
| 15 | Cytoplasmic male sterility in rape plants (Brassica napus L) 显示文摘 | Shiga T Baba S | 1971 | Jap J Breeding1971，21，2： | 1 |
| 16 | Prevalence and persistence of depression in patients with implantable cardioverter defibrillator: a 2-year longitudinal study显示文摘 | Suzuki T Shiga T Kuwahara K | 2010 | Pacing Clin Electrophysiol2010，33，12： | 1 |
| 17 | Super water-repellent surfaces with fractal structures and their potential application to biological studies 显示文摘 | Yan Hu Shiga H Ito E | 2006 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2006，284，： | 1 |
| 18 | Correlation between myeloperoxidase quantified neutrophil accumlation and ischemic brain injury in the rat:effects of neutrophil depletion显示文摘 | Matsuo Y Onodera H Shiga Y | 1994 | Stroke1994，25，7： | 1 |
| 19 | Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease显示文摘 | Shiga Y Miyazawa K Sato S | 2004 | Neurology2004，63，3： | 1 |
| 20 | Laboratory and imaging studies for the diagnosis of prion disease显示文摘 | Shiga Y Miyazawa K Takada A | 2003 | Rinsho Shinkeigaku2003，43，11： | 1 |
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