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| 1 | Immunogenetic biomarkers in inflammatory bowel diseases:Role of the IBD3 region显示文摘Many studies have demonstrated the linkage between the IBD3 region(6p21.1-23),an area which encompasses the famous human leukocyte antigen(HLA) complex,and Crohn's disease(CD) or ulcerative colitis(UC).IBD3 is the only region that meets genome-wide significance,and provides stronger evidence of the linkage than 16p13.1-16q12.2(IBD1),the locus that contains the susceptibility gene CARD15.However,despite these findings,IBD3 susceptibility genes remain elusive and unclear due to the strong linkage disequilibrium,extensive polymorphism,and high gene density that characterize this area and also due to varying allele frequencies in populations around the world.This area presents an extremely high abundance of genes,including the classical and non-classical major histocompatibility complex(MHC) class Ⅰ and Ⅱ genes,and other genes,namely MHC class Ⅲ genes tumor necrosis factor(TNF)-α and-β,and Hsp,whose proteins play key functions in immunological processes.To date,it is not clear which genes within the MHC family contribute to the IBD pathogenesis,although certain HLA alleles have been associated with IBD.Recent insights into the biological function of other genes encoded within the IBD3 region,such as the MHC class Ⅰ chain-related(MIC) genes,have led investigators to a more comprehensive exploration of this region.MHC class Ⅰ chain-related molecule A(MICA) is highly polymorphic and interacts with NKG2 D,its receptor on the surface of NK,Tγδ and T CD8+ cells.Increased expression of MICA in intestinal epithelial cells and increased expression of NKG2 D in CD4+ T cells(lamina propria) in patients with CD have also been reported.MICA alleles have also been associated with IBD,and a variation at amino acid position 129 of the α2-heavy chain domain seems to categorize MICA alleles into strong and weak binders of NKG2 D receptor,thereby influencing the effector cells' function.In this regard,a relevant role of MICA-129-Val/Met single nucleotide polymorphism has recently been implicated in the pathogenesis of IBD.TNF-α and-β also play an important role in inflammatory response.In fact,IBD is commonly treated with TNF-α inhibitors.Additionally,polymorphisms of TNF-α gene are known to affect the gene expression level and particular TNF-α genotypes may influence the response of IBD patients treated with TNF-α inhibitors. | Manuel Muro Ruth López-Hernández Anna Mrowiec | 2014 | World Journal of Gastroenterology2014，20，41： | 6 |
| 2 | Pancreatic intraductal papillary mucinous neoplasms:Current diagnosis and management显示文摘Intraductal papillary mucinous neoplasms(IPMNs)represent approximately 1%of all pancreatic neoplasms and 25%of cystic neoplasms.They are divided into three types:main duct-IPMN(MD-IPPMN),branch duct-IPMN(BD-IPMN),and mixed type-IPMN.In this review,diagnostics,including clinical presentation and radiological investigations,were described.Magnetic resonance imaging is the most useful for most IPMNs.Management depends on the type and radiological features of IPMNs.Surgery is recommended for MD-IPMN.For BD-IPMN,management involves surgery or surveillance depending on the tumor size,cyst growth rate,solid components,main duct dilatation,high-grade dysplasia in cytology,the presence of symptoms(jaundice,new-onset diabetes,pancreatitis),and CA 19.9 serum level.The patient’s age and comorbidities should also be taken into consideration.Currently,there are different guidelines regarding the diagnosis and management of IPMNs.In this review,the following guidelines were presented:Sendai International Association of Pancreatology guidelines(2006),American Gastroenterological Association guidelines,revised international consensus Fukuoka guidelines(2012),revised international consensus Fukuoka guidelines(2017),and European evidence-based guidelines according to the European Study Group on Cystic Tumours of the Pancreas(2018).The Verona Evidence-Based Meeting 2020 was also presented and discussed. | Beata Jabłońska PawełSzmigiel Sławomir Mrowiec | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 3 |
| 3 | Prognostic factors for survival post surgery for patients with gastrointestinal stromal tumors显示文摘 | Mrowiec S Jab/oflska B Liszka L | 2012 | Eur Surg Res2012，48，1： | 1 |
| 4 | Immune abnormalities in aneurysmal subarachnoid haemorrhage patients:relation to delayed cerebral vasospasm显示文摘 | Chrapusta S J Górski A Mrowiec T | 2000 | Scand J Immunol2000，51，4： | 1 |
| 5 | Modeling of green roofs' hydrologic performance using EPA' s SWMM 显示文摘 | BURSZTA-ADAMIAK E MROWIEC M | 2013 | Water Science and Technology2013，68，1： | 1 |
| 6 | Effect of selenium on macro- and microelement distribution and physiological parameters of rape and wheat seedlings exposed to cadmium stress显示文摘 | Maria Zembala Maria Filek Stanis?aw Walas Halina Mrowiec Andrzej Korna? Zbigniew Miszalski Helin? Hartikainen | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 7 | Comparison of controlled vs non-controlled rate freezing of umbilical cord blood units 显示文摘 | Mrowiec Z R Fernandez DeLeon M Marchioni M | 2004 | Blood ( ASH Annual Meeting Abstracts)2004，104，： | 1 |
| 8 | Characterizaton of tumorinduced platdet aggregation:The role of immunorelated GPIb and GP Ⅱb/Ⅲa expression by MCF-7 breast cancer cellsl显示文摘 | Oleksowicz L Mrowiec Z Schnartz E | 1995 | Thromb Res1995，79，3： | 1 |
| 9 | Platelet activation induced by interleukin - 6: Evidence for a mechanism involving arachidonic acid metabolism 显示文摘 | Oleksowicz L Mrowiec Z Zuckerman D | 1994 | Thrombosis & Haemostasis1994，72，2： | 1 |
| 10 | Comparison of controlled vs non-controlled rate freezing of umbilical cord blood units显示文摘 | Mrowiec Z R Fernandez-De Leon M Marchioni M | 2004 | Ashmtg2004，104，11： | 1 |
| 11 | Prognostic factors for survival post surgery for patients with gastrointestinal stromal tu- mors显示文摘 | Mrowiec S Jablofiska B Liszka L | 2012 | Eur Surg Res2012，48，1： | 1 |
| 12 | Kinetics of solid drying in fluidized bed显示文摘 | Ciesielczyk W Mrowiec M | | 0，，： | 1 |
| 13 | Characterization of tumor-induced platelet aggregation:the role of immunorelated GPⅠ b and GP Ⅱ b/Ⅲ a expression by MCF-7 breast cancer cells显示文摘 | Oleksowicz L Mrowiec Z Schwartz E | 1995 | Thromb Res1995，79，3： | 1 |
| 14 | Comparison of wet microwave digestion methods of plant materials for the determination of metals by flame atomic absorption spectrometry显示文摘 | STANISAW WALAS MAGORZATA JJTOWICZ HALINA MROWIEC | 2006 | Environment Analysis Chemistry2006，84，13： | 1 |
| 15 | Interleukin (IL)-I Gene Cluster in Infla matory Bowel Disease, Is IL-1RA Implicated in the Disease Onset and Outcome显示文摘 | Muro M Mrowiec A | 2015 | Dig Dis Sei2015，60，5： | 1 |
| 16 | Determination of cadmium and lead in plant materials by flow-injection flame atomic-adsorption spectrometry显示文摘 | Wales S Borowska E Herda M Herman M Mrowiec H | 1998 | International Joural of Environmental Analytical Chemistry1998，72，3： | 1 |
| 17 | A novel technique for preparing improved buffy coat platelet concent rates 显示文摘 | Mrowiec ZR Oleksowicz L Dutcher JP | 1995 | Blood Cells Mol Dis1995，21，1： | 1 |
| 18 | Platelet activation induced by interleukin-6:Evidence for a mechanism involving arachidonie acid metabolism显示文摘 | Oleksowicz L Mrowiec Z Zuckerman D | 1994 | Thrombosis & Haemostasis1994，72，2： | 1 |
| 19 | Platelet activation induced by interleukin-6:evidence for a mechanism involving arachidonic acid metabolism显示文摘 | Oleksowicz L Mrowiec Z Zuckerman D | 1994 | Thromb Haemost1994，72，： | 1 |
| 20 | A novel technique for preparing improved bully coat platelet concentrates 显示文摘 | Mrowiec ZR Oleksowicz L Dutcher JP | 1995 | Blood Cells Mol Dis1995，21，1： | 1 |
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