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| 1 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 2 | Titanium elastic nail fixation for paediatric femoral and tibial fractures显示文摘 | El-Adl G Mostafa MF Khalil MA | 2009 | Acta Orthop Belg2009，75，4： | 1 |
| 3 | Surgical treatment of displaced intro-articular calcaneal fracture using a single small lat- eral approaeh显示文摘 | Mostafa MF El-Adl G Hassanin EY | 2010 | Strategies Trauma Limb Reconstr2010，5，2： | 1 |
| 4 | Surgical treatment of displaced intra-articular caleaneal fracture using a single small lat- eral appwach 显示文摘 | Mostafa MF E1-Adl G Hassanin EY | 2010 | Strategies Trauma Limb Reeonstr2010，5，2： | 1 |
| 5 | Which has greater analgesic effect:intrathecal nalbuphine or intrathecal tramadol显示文摘 | Mostafa MG Mohamad MF Farrag WSH | 2011 | J Am Sci2011，7，： | 1 |
| 6 | Titanium elastic nail fixa- tion for paediatric femoral and tibial fractures显示文摘 | E1-Adl G Mostafa MF Khalil MA | 2009 | Acta Orthop Belg2009，75，4： | 1 |
| 7 | Surgical treat ment of displaced intra-artieular calcaneal fracture using a single small lateral approach 显示文摘 | Mostafa MF El-Adl G Hassanin EY | 2010 | Strategies Trauma Limb Reconstr2010，5，2： | 1 |
| 8 | Surgical treatment of dis- placed intra-articular calcaneal fractureusing a single small lateral ap- proach 显示文摘 | Mostafa MF El-Adl G Hassanin EY | 2010 | Strat Traum Limb Recon2010，5，2： | 1 |
| 9 | Surgical treat- ment of displaced intra - articular calcaneal fracture using asingle small lateral approach 显示文摘 | Mostafa MF E1 - Adl G Hassanin EY | 2010 | Strategies Trauma Limb Reconstr2010，5，2： | 1 |
| 10 | Titanium elastic nail fixation for paediatric femoral and tibial fractures显示文摘 | El-Adl G Mostafa MF Khalil MA | | 0，，04： | 1 |
| 11 | Titanium elastic nail fixation for pae- diatric femoral and tibial fractures 显示文摘 | El- Adl G Mostafa MF Khalil MA et al | 2009 | Acta Orthop Belg2009，75，4： | 1 |
| 12 | Recycling of extracorporeally irradia- ted autogratt for malignant bone tumors:Long-term follow- up 显示文摘 | Kotb SZ Mostafa MF | 2013 | Ann Plast Surg2013，71，5： | 1 |
| 13 | Titanium elastic nail fixa- tion for paediatric femoral and tibial fractures 显示文摘 | E1-AdlG Mostafa MF KhalilMA | 2009 | Acta Orthop Belg2009，75，4： | 1 |
| 14 | Lysophosphatidylcholineacyltransferase 1 (LPCAT1) upregulation in breast carcinomacontributes to tumor progression and predicts early tumorrecurrence显示文摘 | Abdelzaher E Mostafa MF | 2015 | Tumour Biol2015，36，7： | 1 |
| 15 | Identification of MMP-9as a biomarker for detecting progression of chronic obstructive pulmonary disease显示文摘 | Abd El-Fatah MF Ghazy MA Mostafa MS | 2015 | Biochem Cell Biol2015，93，6： | 1 |
| 16 | Surgical treatment of displaced intra-articular calcaneal fracture using a single small lat- eral approach显示文摘 | Mostafa MF E1-Adl G Hassanin EY | 2010 | Strategies Trauma Limb Reconstr2010，5，： | 1 |
| 17 | Surgical treat- ment of displaced intra - articular ealcaneal fracture using a single small lateral approach 显示文摘 | Mostafa MF El- Adl G Hassanin EY | 2010 | Strategies Trauma Limb Reconstr2010，5，2： | 1 |
| 18 | Treatment of distal radial fracture with antegrade intramedullary Kirschner wires 显示文摘 | Mostafa MF | 2013 | Strat Trauma Limb Reeonstr2013，2，1： | 1 |
| 19 | Surgical treatment of displaced intra-articular calcaneal fracture using a single small lateral approach 显示文摘 | Mostafa MF E1-Adl G Hassanin EY | 2010 | Strategies Trauma Limb Reconstr2010，5，2： | 1 |
| 20 | Titanium elastic nail fixa- tion for paediatric femoral and tibial fractures 显示文摘 | El-Adl G Mostafa MF Khalil MA | 2009 | Acta Orthop Belg2009，75，4： | 1 |
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