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| 1 | Bone marrow microenvironment: The guardian of leukemia stem cells显示文摘Bone marrow microenvironment (BMM) is the main sanctuary of leukemic stem cells (LSCs) and protects these cells against conventional therapies. However, it may open up an opportunity to target LSCs by breaking the close connection between LSCs and the BMM. The elimination of LSCs is of high importance, since they follow cancer stem cell theory as a part of this population. Based on cancer stem cell theory, a cell with stem cell-like features stands at the apex of the hierarchy and produces a heterogeneous population and governs the disease. Secretion of cytokines, chemokines, and extracellular vesicles, whether through autocrine or paracrine mechanisms by activation of downstream signaling pathways in LSCs, favors their persistence and makes the BMM less hospitable for normal stem cells. While all details about the interactions of the BMM and LSCs remain to be elucidated, some clinical trials have been designed to limit these reciprocal interactions to cure leukemia more effectively. In this review, we focus on chronic myeloid leukemia and acute myeloid leukemia LSCs and their milieu in the bone marrow, how to segregate them from the normal compartment, and finally the possible ways to eliminate these cells. | Mohammad Houshmand Teresa Mortera Blanco Paola Circosta Narjes Yazdi Alireza Kazemi Giuseppe Saglio Mahin Nikougoftar Zarif | 2019 | World Journal of Stem Cells2019，11，8： | 2 |
| 2 | Ductus Arteriosus Patency With Stenting in Critical Pulmonary Stenosis and Pulmonary Atres ia With Intact Interventricular Septum显示文摘 | Mortera C Rissech M Bartrons J | 2005 | Revista Espanola de Ca rdiologiy2005，58，5： | 1 |
| 3 | Age-related neuronal loss in the rat brain starts at the end of adolescence显示文摘 | Priscilla Mortera Suzana Herculano-Houzel | 2012 | Front Neuroanat2012，6，： | 1 |
| 4 | Routine prenatal ultrasound screening for fetal abnormalities:22 years'experience显示文摘 | Carrera JM Torrents M Mortera C | | 0，，03： | 1 |
| 5 | Disruption of the alsSD operon of Enterococcus faecalis impairs growth on pyruvate at low pH显示文摘 | Repizo G D Mortera P Magni C | 2011 | Microbiol2011，157，： | 1 |
| 6 | Routine prenatal ultrasound screening for fetal abnormalities: 22 years' experience显示文摘 | Carrera IM Torrents M Mortera C | 1995 | Ultrasound Obstet Gynecol1995，5，3： | 1 |
| 7 | Structural changes of MCM-41 spheres during ibuprofen release to SBF显示文摘 | Mortera R Fiorilli S Garrone E | 2008 | Studies in Surface Science and Catalysis2008，，： | 1 |
| 8 | Non-fatherhood or mutation? A probabilistic approach to parental exclusion in paternity testing显示文摘 | Dawid AP Mortera J Pascali VL | 2001 | Forensic Sci Int2001，124，1： | 1 |
| 9 | Efficacy and safety of indomethacin therapy for polyhydramnios显示文摘 | Carmona F Martinez RS Mortera C | 1993 | Eur obstet Gyncol Reprod Biol1993，50，： | 1 |
| 10 | Percutaneous closure of ventricular septal defect with an Amplatzer device显示文摘 | MORTERA C PRADA F RISSECH M | 2004 | Rev Esp Cardiol2004，57，： | 1 |
| 11 | Percutaneous closure of ventricular septal defect with an Amplatzar device 显示文摘 | MORTERA C PRADA F RISSECH M | 2004 | Rev Esp Cardiol2004，57，5： | 1 |
| 12 | Percutaneous closure of ventricular septal defect with an Amplatzer device 显示文摘 | MORTERA C PRADA F RISSECH M | 2004 | Rev Esp Cardiol2004，57，： | 1 |
| 13 | Cell-in- duced intracellular controlled release of membrane imper- meable cysteine from a mesoporous silica nanoparticle- based drug delivery system 显示文摘 | Mortera R Vivero-Escoto J Slowing I I | 2009 | Chem Commun2009，，22： | 1 |
| 14 | Load carrying capacity of concrete structures with corroded reinforcement显示文摘 | RODRIGUEZ J MORTERA L CASAL J | 1997 | Con- struction and Building Materials1997，11，4： | 1 |
| 15 | Probabilistic expert systems for DNA mixture profiling 显示文摘 | Mortera J Dawid A P Lauritzen S L | 2003 | Theor Popul Biol2003，63，3： | 1 |
| 16 | Percutaneous closure of ventricular septal defect with an Amplatzar device显示文摘 | MORTERA C PRADA F RISSECH M | 2004 | Rev Esp Cardiol2004，57，5： | 1 |
| 17 | Percutaneous closure of ventricular septal defect with an Amplatzer device显示文摘 | MORTERA C PRADA F RISSECH M | 2004 | Rev Esp Cardiol2004，57，： | 1 |
| 18 | Disruption of the a/sSD operon of Enterococcus faecalis impairs growth on pyruvate at low pH 显示文摘 | Repizo G D Mortera P Magni C | 2011 | Mierobiology-Sgm2011，157，： | 1 |
| 19 | Structural changes of MCM-41 Spheres During Ibuprofen Re- lease to SBF显示文摘 | Mortera R FioriUi S Garrone E | 2008 | Studies in Surface Science and Ca- talysis2008，174，： | 1 |
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