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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Germline mutations in PRKCSH are associated with autosomal dominant polycystic liver disease显示文摘 | Drenth JP de Morsche RH Smink R | 2003 | Nat Genet2003，33，3： | 2 |
| 4 | Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome显示文摘 | Lecke SB Mattei F Morsch DM | 2011 | Fertil Steril2011，95，6： | 1 |
| 5 | Antidepressants inhibit human acetylcholinesterase and butyrylcholinesterase activity显示文摘 | Muller TC Rocha JB Morsch VM | 2002 | Biochim Biophys Acta2002，1587，1： | 1 |
| 6 | SCNgA mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels显示文摘 | Drenth JP te Morsche RH Guillet G | 2005 | J Invest Dermatol2005，124，6： | 1 |
| 7 | Genetic heterogeneity and exclusion of a modifying locus at 2q in a family with autosomal dominant primary erythermalgia 显示文摘 | Burns TM Te Morsche RH Jansen JB | 2005 | Br J Dermatol2005，153，1： | 1 |
| 8 | Electrophysiological analysis of neuromuscular synaptic function in myasthenia gravis patients and animal models显示文摘 | Plomp JJ Morsch M Phillips WD | 2015 | Exp Neurol2015，270，1： | 1 |
| 9 | Do hyperactivity,impulsivity and inattention have an impact on the ability of facial affect recognition in children with autism and ADHD?显示文摘 | Sinzig J Morsch D Lehmkuhl G | 2008 | Eur Child Adolesc Psychiatry2008，17，2： | 1 |
| 10 | Dynamics of Bose-Einstein condensates in optical lattices显示文摘 | Morsch O Oberthaler M | 2006 | Rev Mod Phys2006，78，： | 1 |
| 11 | COX-2 polymorphisms and the risk for head and neck cancer in white patients 显示文摘 | Peters WH Lacko M Te Morsche RH | 2009 | Head Neck2009，31，： | 1 |
| 12 | Characterization of the reactivity pattern of murine monoclonal antibodies against wild-type hepatitis B surface antigen to G145R and other naturally occurring 'a' loop escape mutations显示文摘 | Cooreman MP Van Roosmalen MH Morsche Rte | 1999 | Hepatology1999，30，5： | 1 |
| 13 | Health-related quality of life among haemodialysis patients relationship with clinical indicators, morbidity and mortality显示文摘 | Morsch CM Goncalves LF Barros E | 2006 | J Clin Nurs2006，15，： | 1 |
| 14 | LC determination of enrofloxacin 显示文摘 | Souza M J Bittencourt C F Morsch L M | 2002 | J Pharma Biomed Anal2002，28，： | 1 |
| 15 | Bloch Oscil- lations and Mean-Field Effects of Bose-Einstein Con- densates in 1D Optical Lattices 显示文摘 | Morsch O Mtlller J H Cristiani M | 2001 | Phys Rev Lett2001，87，14： | 1 |
| 16 | Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer显示文摘 | MartinLacko Hennie M.J.Roelofs Rene H.M.te Morsche Adri C.Voogd Michel B. OudeOphuis Wilbert H.M.Peters Johannes J.Manni | 2010 | Int J Cancer2010，，12： | 1 |
| 17 | Over-expression of COX-2 mRNA in colorectal cancer显示文摘 | Roelofs HM Te Morsche RH van Heumen BW | 2014 | BMC Gastroenterol2014，14，： | 1 |
| 18 | Short mucin 6 alleles are associated with H pylori infection显示文摘AIM: To investigate the relationship between mucin 6 (MUC6) VNTR length and H pylori infection. METHODS: Blood samples were collected from patients visiting the Can Tho General Hospital for upper gastrointestinal endoscopy. DNA was isolated from whole blood, the repeated section was cut out using a restriction enzyme (PvuⅡ) and the length of the allelefragments was determined by Southern blotting. H pylori infection was diagnosed by 14C urea breath test. For analysis, MUC6 allele fragment length was dichotomized as being either long (> 13.5 kbp) or short (≤ 13.5 kbp) and patients were classif ied according to genotype [long- long (LL), long-short (LS), short-short (SS)].RESULTS: 160 patients were studied (mean age 43 years, 36% were males, 58% H pylori positive). MUC6 PvuⅡ-restricted allele fragment lengths ranged from7 to 19 kbp. Of the patients with the LL, LS, SS MUC6 genotype, 43% (24/56), 57% (25/58) and 76% (11/46) were infected with H pylori, respectively (P = 0.003).CONCLUSION: Short MUC6 alleles are associated with H pylori infection. | Thai V Nguyen Marcel JR Janssen Paulien Gritters René HM te Morsche Joost PH Drenth Henri van Asten Robert JF Laheij Jan BMJ Jansen | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 19 | Genetic heterogeneity and exclusion of a modifying locus at 2q in a family with autosomal dominant primary erythermalgia显示文摘 | Bums TM Te Morsche RH Jansen JB | 2005 | Br J Dermatol2005，153，1： | 1 |
| 20 | Diet - in-duced changes in AChE activity after long - term exposure 显示文摘 | KAIZER R R DA SILVA A C MORSCH V M | 2004 | Neurochem Res2004，29，12： | 1 |
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